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A Surface Plasmon Resonance Approach to Monitor Animal Toxin Interactions with Isolated Voltage-gated Sodium Channel Paddle Motifs and the Use Thereof

Animal toxins that inhibit voltage-gated sodium (Nav) channel fast inactivation can do so through an interaction with the S3b-S4 helix-turn-helix motif, or paddle motif, located in the domain IV voltage sensor. Here, we show that the domain IV paddle can be lifted out of the Nav channel and immobilized on sensor chips. Subsequent Surface Plasmon Resonance...

Published: 3/13/2025 | Inventor(s): Pierre Bougis, Marie-France Eauclaire, Frank Bosmans

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Target-based Screening Tool

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Diagnostics, Technology Classifications > Research Tools > Assays