Search Results - pierre+bougis

2 Results

Sort By:

Snake Toxins and their Use as Pharmacological Modulators of GABAa Receptors

Ionotropic γ-aminobutyric acid type A (GABAA) receptors are found primarily in the central nervous system (CNS) where they mediate inhibitory post-synaptic transmission by increasing CI" conductance into the cell. However, GABAA receptor activation can be excitatory in neonatal neurons and dorsal root ganglia where intracellular CI" concentrations...

Published: 3/13/2025 | Inventor(s): Pierre Bougis, Frank Bosmans

Keywords(s): Biologics, CNS and Neurological Disorders, Disease Indication, Peptide, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities

A Surface Plasmon Resonance Approach to Monitor Animal Toxin Interactions with Isolated Voltage-gated Sodium Channel Paddle Motifs and the Use Thereof

Animal toxins that inhibit voltage-gated sodium (Nav) channel fast inactivation can do so through an interaction with the S3b-S4 helix-turn-helix motif, or paddle motif, located in the domain IV voltage sensor. Here, we show that the domain IV paddle can be lifted out of the Nav channel and immobilized on sensor chips. Subsequent Surface Plasmon Resonance...

Published: 3/13/2025 | Inventor(s): Pierre Bougis, Marie-France Eauclaire, Frank Bosmans

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Target-based Screening Tool

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Diagnostics, Technology Classifications > Research Tools > Assays