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Disulfide Bond-free and Fibril-specific Nanobodies Prevent the Prion-like α-synuclein Spreading

Unmet NeedLewy bodies dementia (LBD) is one of the most common causes of dementia, including Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB). Both clinical and experimental observations support the hypothesis of prion-like α-syn driving α-synucleinopathy, hence targeting the prion-like α-syn may be a new approach to treat...

Published: 3/14/2025 | Inventor(s): Xiaobo Mao, Wenjing Wang, Yemima Raini, Yuqing Liu, Ramhari Kumbhar

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