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Disulfide Bond-free and Fibril-specific Nanobodies Prevent the Prion-like α-synuclein Spreading

Unmet NeedLewy bodies dementia (LBD) is one of the most common causes of dementia, including Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB). Both clinical and experimental observations support the hypothesis of prion-like α-syn driving α-synucleinopathy, hence targeting the prion-like α-syn may be a new approach to treat...

Published: 3/14/2025 | Inventor(s): Xiaobo Mao, Wenjing Wang, Yemima Raini, Yuqing Liu, Ramhari Kumbhar

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A New Method to Suppress Background Noise in Stimulated Emission Depletion (STED) Nanoscopy

Unmet NeedDifferentiating small features, such a membrane fibrils in a cell, or small entities, such as viruses, is made possible by high resolution fluorescence imaging. Stimulated Emission Depletion (STED) Nanoscopy has proven to produce images that can overcome the diffraction limit and provide nanometer resolution of fluorescently labeled samples....

Published: 3/14/2025 | Inventor(s): Taekjip Ha, Jong-Chan Lee, Ye Ma

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Category(s): Technology Classifications > Diagnostics > Diagnostic Imaging