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Disulfide Bond-free and Fibril-specific Nanobodies Prevent the Prion-like α-synuclein Spreading

Unmet NeedLewy bodies dementia (LBD) is one of the most common causes of dementia, including Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB). Both clinical and experimental observations support the hypothesis of prion-like α-syn driving α-synucleinopathy, hence targeting the prion-like α-syn may be a new approach to treat...

Published: 3/14/2025 | Inventor(s): Xiaobo Mao, Wenjing Wang, Yemima Raini, Yuqing Liu, Ramhari Kumbhar

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PtCu Nanozyme Scavenging ROS for Prevention of Pathologic α-Synuclein Transmission

Description: Unmet Need Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized with misfolded α-synuclein (α-syn) accumulation in Lewy bodies (LB). Although some α-syn mutations have been associated with familial PD, the majority cases are sporadic with unknown etiology. Tremendous efforts have been made to develop...

Published: 3/14/2025 | Inventor(s): Xiaobo Mao, Weiwei He, Yuqing Liu

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Category(s): Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Neurodegeneration, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers

Measurement of Blood Volume using Velocity-Selective Pulse Trains on MRI

INVENTION NOVELTY A novel velocity-selective inversion pulse sequence that can be used for MR angiography applications. VALUE PROPOSITION There is a growing demand for high–performance imaging that is beneficial in cases where 1.5 Tesla does not work well enough, such as scanning for developmental abnormalities or performing high–resolution MR angiography,...

Published: 3/13/2025 | Inventor(s): Qin Qin

Keywords(s): CNS and Neurological Disorders, Disease Indication, Distortion Elimination Software, Image Processing Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Integrated Imaging System, Interventional and Surgical Systems, Magnetic Resonance Imaging (MRI), Stroke, Surgical Navigation

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Stroke, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Neurology, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis

Velocity Selective Pulses with Arbitrary Shape

C12796 NOVEL PULSE SEQUENCE FOR NON-CONTRAST ENHANCED MRIInvention novelty: A novel velocity-selective inversion pulse sequence that can be used for MR angiography applications.Value Proposition:There is a growing demand for high–performance imaging that is beneficial in cases where 1.5 Tesla does not work well enough, such as scanning for developmental...

Published: 3/13/2025 | Inventor(s): Peter van Zijl, Qin Qin

Keywords(s): Image Processing Software, Image Reconstruction Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Category(s): Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices

Functional magnetic resonance imaging (fMRI) methodology using transverse relaxation preparation and non- echo-planar-imaging (EPI) pulse sequences

C12282: Enhanced Whole Brain fMRINovelty: This invention is a method to mitigate geometric distortion and signal dropout when performing whole brain imaging by blood-oxygenation-level-dependent fMRI.Value Proposition: Current approaches to blood-oxygenation-level-dependent (BOLD) fMRI rely on 2D gradient echo (GRE) echo-planar-imaging (EPI), and are...

Published: 3/13/2025 | Inventor(s): Peter van Zijl, Craig Jones, Qin Qin, Jun Hua

Keywords(s): Cancers, CNS and Neurological Disorders, Diabetes, Disease Indication, Image Processing Software, Image Reconstruction Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Inflammatory Disorders, Magnetic Resonance Imaging (MRI), Metabolic Disorders

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Diabetes, Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Metabolic Diseases, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices

Chloroquine-induced Itch is Mediated by Mrgs

C10519: Methods and Compositions for Treating Itch Value Proposition: Inventors have identified a cell receptor family known as Mrgprs that is exclusively expressed in a small subset of neurons. In vitro and animal studies suggest that the Mrg receptor family directly mediates chloroquine (CQ) induced itch. Identification and characterization of Mrgprs...

Published: 3/13/2025 | Inventor(s): David Anderson, Qin Liu, Xinzhong Dong

Keywords(s): Biomarker, CNS and Neurological Disorders, Disease Indication, Infectious Diseases, Inflammatory Disorders, Itch, Malaria, Mechanism of Action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Inflammation, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Neurology > Itch