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The Efficacy of Nanozyme in Neurodegenerative Diseases

Unmet NeedOxidative stress and subsequent prion-like pathology is an essential driver n the pathogenesis of neurodegenerative diseases, including Parkinson’s Disease (PD and Alzheimer’s disease (AD). Currently, only symptomatic treatments are available, and there is a great unmet need to develop a cure. Technology OverviewDisclosed herein are novel...

Published: 3/14/2025 | Inventor(s): Xiaobo Mao, Shuya Li, Weiwei He

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Clinical and Disease Specializations > Neurology > Parkinson’s Disease, Technology Classifications > Therapeutic Modalities > Proteins

PtCu Nanozyme Scavenging ROS for Prevention of Pathologic α-Synuclein Transmission

Description: Unmet Need Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized with misfolded α-synuclein (α-syn) accumulation in Lewy bodies (LB). Although some α-syn mutations have been associated with familial PD, the majority cases are sporadic with unknown etiology. Tremendous efforts have been made to develop...

Published: 3/14/2025 | Inventor(s): Xiaobo Mao, Weiwei He, Yuqing Liu

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Neurodegeneration, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers

HIV-1 Latency Cell Line Construction

Unmet NeedApproximately 38 million people are currently living with human immunodeficiency virus (HIV) globally. HIV is a serious health issue, and around 1 million people die from HIV/AIDS related illnesses each year. Currently, there is no cure for HIV, only prevention and treatment techniques exist. Current methods of treatment use antiretroviral...

Published: 3/14/2025 | Inventor(s): Robert Siliciano, Weiwei Dai

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > Covid-19, Technology Classifications > Research Tools > Cell Lines

Identification of Novel Coumestan Derivatives as Pks13 Inhibitors against Mycobacterium Tuberculosis

Unmet NeedTuberculosis (TB) is an infectious disease caused by the bacteria Mycobacterium tuberculosis (Mtb), which typically impacts the lungs. In 2016, there were 10.4 million new cases of TB and 1.7 million deaths worldwide, with approximately one-fourth of the world’s population infected. As a result, TB is one of the leading infectious disease...

Published: 3/14/2025 | Inventor(s): William Bishai, Shichun Lun, Li-Fang Yu, Shu-Huan Wang, Fan Yang, Jie Tang, Hendra Gunosewoyo, Ashlee Earl, Abigail Manson, Wei Zhang

Keywords(s): Antagonists/Inhibitors, Disease Indication, Infectious Diseases, Myobacterium Tuberculosis, Natural compounds, Non-novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Tuberculosis (TB)

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB)

Hypoxia-inducible factor reporter cell lines

Unmet NeedLow oxygen levels are a characteristic of many types of solid tumors. High levels of HIF1α, the transcription factor responsible for energy utilization under hypoxic conditions, has been implicated in tumor growth and resistance, angiogenesis, and poor patient prognosis. For these reasons, HIF1α remains an attractive target for novel cancer...

Published: 3/14/2025 | Inventor(s): Peter Espenshade, Wei Shao

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Cell Lines

Itraconazole Analogs and Use Thereof

C11669: Novel Compounds for Cancer and Macular Degeneration TreatmentNovelty: This invention is a series of novel and potent itraconazole derivative that have showed strong activity against tumor growth and macular degeneration.Value Proposition: The novel compounds effectively inhibit angiogenesis, which is critical for tumor growth and macular degeneration....

Published: 3/13/2025 | Inventor(s): Jun Liu, Wei Shi, Kalyan Kumar Pasunooti, Wukun Liu, Ruojing Li, Sarah Head, Yingjun Li

Keywords(s): Antagonists/Inhibitors, Cancers, Disease Indication, Eye Disorders, Macular Degeneration, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Ophthalmology > Macular Degeneration