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Extracellular Vesicle mediated nucleic acid treatment in vivo

Value Proposition· Effective: animal studies showed increased survival and decreased tumor burden in liver cancer model.· Fewer side effects: no immunological reactions or off-target effects· Multiple targets: targets the cancer-stroma interactionsUnmet Need· Many current and pipeline cancer therapeutics, including therapeutic...

Published: 3/13/2025 | Inventor(s): Ling Li, Stephen Gould, Florin Selaru

Keywords(s): Drug Delivery Vehicle, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Antitumor drug interrupting glucose metabolism as a therapeutic strategy for cancer

Value Proposition:· Drug reduces tumor burden by interrupting cancer cells’ reliance on glucose metabolism.· Tolerated by healthy, normal cells.· Potential for combination therapy with other modalities (chemotherapy, radiation, immunotherapy, etc.)Unmet Need· Cancer is the leading cause of death globally, and it’s estimated that...

Published: 3/14/2025 | Inventor(s): Ling He

Keywords(s):

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Local Sustained-release Nanocrystal Formulations to Treat and Prevent GI Fibrosis

Unmet Need: Gastrointestinal (GI) fibrosis, the accumulation of scar tissue in the intestinal wall as a complication in common GI autoimmune diseases such as ulcerative colitis (UC) and Crohn’s disease (CD), leads to intestinal strictures, abdominal pain, and reduced intestinal motility. Current pharmacological and surgical treatment methods have significant...

Published: 3/14/2025 | Inventor(s): Laura Ensign-Hodges, Florin Selaru, Min Kyung Joo, Rachel Shapiro, Ling Li

Keywords(s):

Category(s): Clinical and Disease Specializations > Gastroenterology

New use of Sulconazole to Treat and Prevent GI Fibrosis

Published: 3/14/2025 | Inventor(s): Florin Selaru, Laura Ensign-Hodges, Ling Li, Min Kyung Joo

Keywords(s):

Category(s): Clinical and Disease Specializations > Gastroenterology

Novel peptides for treating and preventing metabolic diseases

Value Proposition:· Drug treats mitochondrial dysfunction by promoting mitochondrial fission and mitophagy. · Decreases fat levels and represses glucose production in the liver to effectively treat diabetes, obesity, and non-alcoholic fatty liver disease.· Possesses antitumor activity via p53-mediated apoptosis Unmet Need· Approximately...

Published: 3/14/2025 | Inventor(s): Ling He

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Obesity, Clinical and Disease Specializations > Diabetes

Locoregional Chemotherapy for Liver Cancers

Unmet NeedOver 800,000 people are diagnosed with liver cancer annually. As the leading cause of cancer death worldwide, liver cancer accounts for more than 700,000 deaths annually. Recently, Johns Hopkins researchers have developed new chemotherapeutic drugs to treat liver cancer that demonstrate higher efficacy than the current standard of care for...

Published: 3/14/2025 | Inventor(s): Florin Selaru, Ling Li

Keywords(s): Antagonists/Inhibitors, Cancers, Disease Indication, Drug Delivery Mechanism, Liver Cancer, Non-novel, Predicted Novelty, Repurposed, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Repurposed Drugs, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Oncology > Liver Cancer

Liver-directed gene delivery via endoscopic retrograde cholangiopoancreatograpy (ERCP) directed hydrodynamic injection

Unmet NeedGene therapies are regarded as a potential revolution in the health sciences and pharmaceutical fields. The number of gene therapy trials has been steadily increasing in the United States, with around 170 trials taking place in 2015. All of these trials aim to treat the causes of different diseases instead of only relieving symptoms. Many...

Published: 3/14/2025 | Inventor(s): Florin Selaru, Vivek Kumbhari, Ling Li

Keywords(s): Drug Delivery Mechanism, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Mini-cancers Utilization as Decision Tools for Personalized Cancer Drug Regimens

The present invention includes methods for identifying chemotherapy treatments specifically suited for each cancer patient. The methods include obtaining a biopsy from the cancer patient; establishing a cancer culture from the biopsy; mixing the cancer culture with a matrix forming mini cancers. The mini cancers are then used to screen chemotherapy...

Published: 3/13/2025 | Inventor(s): Florin Selaru, Ling Li

Keywords(s): Assay, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Research Instrument, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Companion Diagnostics, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

Modification of Membranes with Polydopamine and Silver Nanoparticles formed in situ to Mitigate Biofouling

Modification of Membranes for Improved Water FiltrationJHU REF: C13272Invention Novelty: A novel method for enhancing the anti-adhesive and antimicrobial properties of membranes used in water filtration. Value Proposition: Although membrane filtration is a popular technique for water purification, the use of these systems has been limited by the formation...

Published: 3/13/2025 | Inventor(s): Li Tang, Kai Loon Chen

Keywords(s): HVAC Systems, Industrial Manufacturing, Manufactured Devices, Manufacturing Method, Microfabrication

Category(s): Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Industrial Tech, Technology Classifications > Engineering Tech > Industrial Manufacturing

A computational approach for generating representative hepatitis C virus genomic sequences

C11517: Novel Synthetic Genomic Reconstruct for HCV TherapeuticsNovelty: This technology is an optimized synthetic reconstruct of genotype 1a hepatitis C virus (HCV) that is representative of globally-circulating strains of HCVValue Proposition: The reconstructed HCV genotype 1a virus is highly functional without adaptive mutations, which allows it...

Published: 3/13/2025 | Inventor(s): Supriya Munshaw, Lin Liu, Stuart Ray

Keywords(s): Computational Modeling Tool, Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Discovery/Research Tools, Disease Indication, Hepatitis C Virus (HCV), In Silico Research Tool, Infectious Diseases, Physics

Category(s): Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Infectious Diseases > Hepatitis C Virus (HCV), Technology Classifications > Research Tools

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