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Modulation of Oxidative Stress as a Therapeutic Pathway in Trigeminal Neuralgia

Unmet NeedTrigeminal neuralgia is a condition that affects the fifth cranial nerve, caused either via trigeminal nerve compression or secondary to another medical condition (i.e., multiple sclerosis, facial injury, tumors, etc.). Trigeminal neuralgia results in severe orofacial pain that is exceptionally debilitating, with a profound effect on one’s...

Published: 3/14/2025 | Inventor(s): Michael Lim, Solomon Snyder, Risheng Xu, Chirag Vasavda, Ryan Dhindsa

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Category(s): Clinical and Disease Specializations, Technology Classifications, Technology Classifications > Therapeutic Modalities > Small Molecules

Treatment of Drug Abuse by Preventing GAPDH Nitrosylation

C12097: Novel Treatment for Cocaine Drug AbuseNovelty: A novel therapeutic strategy for cocaine abuse using known compounds.Value Proposition: Cocaine is a powerful addictive stimulant that causes psychological dependence and brain damage. Currently there are no FDA-approved drug for cocaine addiction and overdose, even though it is one of the most...

Published: 3/13/2025 | Inventor(s): Solomon Snyder, Risheng Xu, Nilkantha Sen

Keywords(s): Addiction, Biomarker, CNS and Neurological Disorders, Disease Indication, Mechanism of Action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Addiction, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Therapeutic Modalities