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Conditional expression of human SHH mouse

Unmet Need:Every year, approximately 6,000 children are born with Down syndrome worldwide (see CDC). Down syndrome is ubiquitously associated with cognitive delays, and sometimes accompanied by additional neurological defects (see NDSS). Unfortunately, little is known about how these cognitive deficits arise. Some studies suggest that sonic hedgehog...

Published: 3/13/2026 | Inventor(s): Roger Reeves, Donna Klinedinst, Fabian Fernandez, Feng Gao

Keywords(s):

Category(s): Technology Classifications > Medical Devices > Neurostimulation, Technology Classifications > Medical Devices

Anthracycline doxorubicin-resistant carbonyl reductase-1 knock out mice

C04211: Anthracycline doxorubicin-resistant carbonyl reductase-1 knock out mice Technical Details: The cancer treatment drug doxorubicin (brand name adriamycin) is very effective against tumors, but causes a serious side effect of heart damage. This toxicity occurs in part because the enzyme carbonyl reductase metabolizes the drug into a cardiotoxic...

Published: 3/12/2026 | Inventor(s): Kathleen Gabrielson, Roger Reeves, Lisa Olson

Keywords(s): Basic Research Biomarker, Cancers, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology