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Conditional expression of human SHH mouse

Unmet Need:Every year, approximately 6,000 children are born with Down syndrome worldwide (see CDC). Down syndrome is ubiquitously associated with cognitive delays, and sometimes accompanied by additional neurological defects (see NDSS). Unfortunately, little is known about how these cognitive deficits arise. Some studies suggest that sonic hedgehog...

Published: 4/24/2026 | Inventor(s): Roger Reeves, Donna Klinedinst, Fabian Fernandez, Feng Gao

Keywords(s):

Category(s): Technology Classifications > Medical Devices > Neurostimulation, Technology Classifications > Medical Devices

Segmental Trisomy Modeling Platform

Value Proposition· Value Proposition The disclosed technology describes a system where scientists first use a complete gene catalog of chromosome 21 to identify candidate genes therefore enabling engineering of mice with extra copies of specific chromosome segments using embryonic stem cells. By measuring traits in these mice that mirror Down syndrome...

Published: 4/23/2026 | Inventor(s): Kathleen Gabrielson, Roger Reeves, Lisa Olson

Keywords(s): Basic Research Biomarker, Cancers, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology