Search Results - scheherazade+sadegh-nasseri

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Multi-MHC Targeting Bispecific Antibody Platform for T-Cell Activation Against HIV-Infected Cells

Value Proposition· Superior target stability: Targets conserved HIV structural protein-derived peptide:MHC complexes that are highly expressed and stable, unlike rapidly-internalizing variable Env proteins used by current bispecifics· Comprehensive MHC coverage: First platform addressing HIV peptides across MHC-I, MHC-II, and HLA-E pathways,...

Published: 1/22/2026 | Inventor(s): Srona Sengupta, Robert Siliciano, Scheherazade Sadegh-Nasseri, Jacqueline Douglass

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > HIV, Technology Classifications, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools

Developing a High-throughput Screening Method for Identification and Validation of T Cell Epitopes Based Upon the Mass Spectral Analysis of Antigens Bound to Class II HLA-DR Constructs

Unmet Need: Rational design of immunotherapeutics and biologics relies on clear knowledge of the immunodominant epitopes of antigens or autoimmunogenic epitopes of therapeutic proteins in order to optimize drug development. Immunodominance is defined as restricted responsiveness of T cells to a few selected epitopes from complex antigens. Current...

Published: 1/22/2026 | Inventor(s): Scheherazade Sadegh-Nasseri

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Research Instrument

Category(s): Technology Classifications > Research Tools