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Siglec-8 Ig Fusion Protein and Cell Line Secreting It; Transfected HEK & RBL Cell Lines Stably Expressing Siglec-8 on their Surface

Development of Siglec-8 fusion protein and expression of the protein in HEK & RBL cell lines.JHU REF: [C11910]Invention novelty: Development of novel fusion protein Siglec-8 and its expression in animal cell lines HEK and RBL. Value Proposition:Siglec-8, formerly named SAF-2 is a 431–amino acid protein composed of 3 Ig domains with a 358–amino...

Published: 3/13/2025 | Inventor(s): Bruce Bochner

Keywords(s): Basic Research Biomarker, Cell Signaling, Discovery/Research Tools, Ligand, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

Identification of a Specific Ligand for Siglec-8

C04430: Novel Carbohydrate Based Therapeutic for Allergic, Asthmatic, and Other Inflammatory DisordersNovelty: A Sialic acid immunoglobulin-like lectin-8 (Siglec-8) carbohydrate based ligand has been identified which provides a platform for development of effective therapies for inflammation caused by eosinophil, basophil and mast cell over activity.Value...

Published: 3/13/2025 | Inventor(s): Ronald Schnaar, Bruce Bochner

Keywords(s): Disease Indication, Inflammatory Disorders, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Inflammation, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities