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A Novel and Unique Set of Human Antibodies to Human Resistin and to Human Resitin-like Molecule Beta (RELMB) that can be used to Target these Proteins in Human Disease
Unmet NeedAutoinflammatory responses, your body’s innate defense mechanism against infections and stressors, can become overactive and cause chronic inflammation in various tissues and organs. Inflammatory diseases affect more than 200 million people worldwide and include pulmonary hypertension, scleroderma, rheumatoid arthritis, pulmonary fibrosis,...
Published: 3/13/2025
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Inventor(s):
Roger Johns
Keywords(s):
Antibodies
,
Biologics
,
Cardiovascular Diseases
,
Disease Indication
,
Hypertension
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
Category(s):
Clinical and Disease Specializations
,
Technology Classifications > Therapeutic Modalities > Antibodies
,
Technology Classifications > Therapeutic Modalities > Biologics
,
Clinical and Disease Specializations > Cardiovascular
,
Technology Classifications > Therapeutic Modalities
,
Clinical and Disease Specializations > Cardiovascular > Hypertension
Compositions and Methods for Treating Diseases and Conditions Associated with Activation of the NLRP3 Inflammasome
Unmet NeedAutoinflammatory responses, your body’s innate defense mechanism against infections and stressors, can become overactive and cause chronic inflammation in various tissues and organs. Inflammatory diseases affect more than 200 million people worldwide and include pulmonary hypertension, scleroderma, rheumatoid arthritis, pulmonary fibrosis,...
Published: 3/14/2025
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Inventor(s):
Roger Johns
Keywords(s):
Category(s):
Clinical and Disease Specializations > Cardiovascular > Hypertension
,
Clinical and Disease Specializations > Cardiovascular > Heart Failure
,
Clinical and Disease Specializations > Infectious Diseases > Covid-19
,
Clinical and Disease Specializations > Inflammation
,
Clinical and Disease Specializations > Inflammation > Chronic Inflammatory Diseases
,
Clinical and Disease Specializations > Respiratory Diseases
,
Clinical and Disease Specializations > Respiratory Diseases > Chronic Obstructive Pulmonary Disorder
,
Clinical and Disease Specializations > Respiratory Diseases > Pulmonary Hypertension
,
Technology Classifications > Diagnostics
,
Technology Classifications > Diagnostics > Diagnostic Biomarkers
,
Technology Classifications > Diagnostics > In Vitro Diagnostics
,
Technology Classifications > Research Tools > Assays
,
Technology Classifications > Therapeutic Modalities > Antibodies
Automated Blood Pressure Monitoring Using Ultrasound
Unmet Need:Blood pressure monitoring is extremely important in a clinical setting for understanding the current state of a patient, as well as for the diagnosis of various conditions. Many current devices have limitations in accuracy in obese patients, patients with severe vascular disease, and during episodes of low blood pressure. Additionally, they...
Published: 3/14/2025
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Inventor(s):
Laeben Lester
,
Brian Bush
Keywords(s):
Category(s):
Clinical and Disease Specializations > Cardiovascular > Hypertension
,
Technology Classifications > Computers, Electronics & Software > Sensors
HBP SCP: Hypertension Self-Care Profile
An express license for this technology is available via JHTV's online licensing portal.Unmet NeedSignificant economic burdens arise from multiple complications and premature mortality from hypertension (HBP) for hypertensive individuals, their families, and society. Despite numerous published HBP management and behavioral treatment guidelines, blood...
Published: 3/13/2025
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Inventor(s):
Hae-Ra Han
Keywords(s):
Cardiovascular Diseases
,
Disease Indication
,
Healthcare Management
,
Hypertension
,
Operations Management
,
Readiness Assessment Tools
Category(s):
Technology Classifications > Computers, Electronics & Software > Healthcare IT
,
Clinical and Disease Specializations > Cardiovascular > Hypertension
,
Express Licensing
Supramolecular Hydrogel Applications to the Carotid Bodies to Treat Hypertension and Sleep Apnea in Obesity
Unmet NeedOver one-third of adults in the U.S. (36.5%) have obesity. Further, obesity leads to increased cardiovascular morbidity and mortality via multiple adverse mechanisms that include increased prevalence and severity of hypertension (often resistant to treatment) and obstructive sleep apnea (OSA). Currently, no pharmacotherapy exists for OSA....
Published: 3/13/2025
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Inventor(s):
Vsevolod Polotsky
,
Honggang Cui
,
Roxana Mitrut
,
Mi-kyung Shin
Keywords(s):
Cardiovascular Diseases
,
CNS and Neurological Disorders
,
Disease Indication
,
Drug Delivery Vehicle
,
Hypertension
,
Metabolic Disorders
,
Obesity
,
Peptides/Prodrugs
,
Sleep Apnea
,
Sleep Disorders
,
Small Molecules
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
Category(s):
Technology Classifications > Therapeutic Modalities > Peptides
,
Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms
,
Clinical and Disease Specializations > Cardiovascular > Hypertension
,
Clinical and Disease Specializations > Sleep Disorders > Sleep Apnea
,
Clinical and Disease Specializations > Obesity
Circulating Pulmonary Hypertension Biomarker
UNMET NEEDPulmonary hypertension (PH) can result from a number of changes in the cardiorespiratory system that cause increased pulmonary arterial pressure. Hemodynamic evaluation is one of the best diagnostics, but pulmonary artery catheterization is expensive and invasive; therefore biomarkers that diagnosis and/or predict PH are needed. Some of...
Published: 3/13/2025
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Inventor(s):
Jun Yang
,
Allen Everett
Keywords(s):
Biomarker
,
Cardiovascular Diseases
,
Clinical Diagnostics
,
Diagnostic Biomarker
,
Disease Indication
,
Hypertension
,
In Vitro Diagnostics
,
Lung Disorders
,
Pulmonary Hypertension
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Cardiovascular > Hypertension
,
Technology Classifications > Diagnostics > Biomarkers
,
Technology Classifications > Diagnostics > Diagnostic Biomarkers
,
Technology Classifications > Diagnostics > In Vitro Diagnostics
,
Clinical and Disease Specializations > Cardiovascular
,
Technology Classifications > Diagnostics
Biomarkers of Pulmonary Hypertension
C11797: Blood Test Biomarkers for Pulmonary Arterial HypertensionNovelty: This invention is a novel set of circulating biomarkers found in serum and plasma which can be used for diagnostic and prognostic testing of Pulmonary Arterial Hypertension (PAH).Value Proposition: Currently, the first line of treatment for PAH is prescribing vasodilators, which...
Published: 3/13/2025
|
Inventor(s):
Zongming Fu
,
Allen Everett
Keywords(s):
Biomarker
,
Cardiovascular Diseases
,
Clinical Diagnostics
,
Diagnostic Biomarker
,
Disease Indication
,
Hypertension
,
In Vitro Diagnostics
,
Prognostic Biomarker
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Cardiovascular > Hypertension
,
Technology Classifications > Diagnostics > Biomarkers
,
Technology Classifications > Diagnostics > Diagnostic Biomarkers
,
Technology Classifications > Diagnostics > In Vitro Diagnostics
,
Technology Classifications > Diagnostics > Prognostics Biomarkers
,
Clinical and Disease Specializations > Cardiovascular
,
Technology Classifications > Diagnostics
Hypoxia-induced Mitogenic Factor
C04061: Hypoxia-induced Mitogenic FactorValue Proposition: Johns Hopkins University is seeking licensees for Hypoxia-Induced Mitogenic Factor (HIMF/ FIZZ1/RELM), a cell line expressing tagged HIMF, antibodies to HIMF and receptor. HIMF provides a wide array of novel biomarkers and therapeutic targets for lung, vascular, cardiac and inflammatory diseases,...
Published: 3/13/2025
|
Inventor(s):
Xingwu Teng
,
Dechun Li
,
Roger Johns
Keywords(s):
Biomarker
,
Cardiovascular Diseases
,
Clinical Diagnostics
,
Diagnostic Biomarker
,
Disease Indication
,
Hypertension
,
In Vitro Diagnostics
,
Inflammatory Disorders
,
Lung Disorders
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Cardiovascular > Hypertension
,
Technology Classifications > Diagnostics > Biomarkers
,
Technology Classifications > Diagnostics > Diagnostic Biomarkers
,
Technology Classifications > Diagnostics > In Vitro Diagnostics
,
Clinical and Disease Specializations > Cardiovascular
,
Technology Classifications > Diagnostics
,
Technology Classifications > Therapeutic Modalities > Antibodies
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