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Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers

Improved Treatment Prognosis For CancersJHU REF: C12842Invention Novelty:This technology offers a prognostic panel derived from the gene expression of several different cancers, which was validated in multiple primary human samples. The panel, termed "AIM", differentiates patients into two tiers that correspond to a set of suggested treatment...

Published: 6/27/2024 | Inventor(s): Cynthia Zahnow, Stephen Baylin, Angela Guzzetta, Katherine Chiappinelli, Huili Li, Nita Ahuja

Keywords(s): Antagonists/Inhibitors, Biomarker, Cancers, Clinical Diagnostics, Combination, Disease Indication, Epithelial Cancer, In Vitro Diagnostics, Non-novel, Pharmakodynamic Biomarker, Predicted Novelty, Repurposed, Small Molecules, Targeted Therapy/Immunotherapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Epithelial Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Molecular Signatures of Invasive Cancer Subpopulations

C11851: Assay and molecular signature to identify invasive cancer cell population in tumorsNovelty: This invention is an assay for evaluating the metastatic potential of epithelial cancers, and a molecular signature linked to aggressive and invasive cancer subpopulations.Value Proposition: Inventors have developed an assay to enable stratification of...

Published: 6/27/2024 | Inventor(s): Kevin Cheung, Andrew Ewald

Keywords(s): Assay, Basic Research Biomarker, Biomarker, Cancer Cells, Cancers, Cell Model, Clinical Diagnostics, Diagnostic Biomarker, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Mechanism-of-action Biomarker, Prognostic Biomarker, Risk Stratification, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Epithelial Cancer