Search Results - clinical+and+disease+specializations+%3e+oncology+%3e+lung+cancer

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Value PropositionFirst-in-Class Targeting of a Novel Oncogenic Ion Channel: Inhibiting KCNK9 represents a new therapeutic modality in cancers where traditional approachesTumor-Specific Overexpression Enables Selectivity: KCNK9 is overexpressed in various tumors (e.g., breast, gastric, lung) but has limited expression in most normal tissuesPro-Apoptotic...

Published: 6/27/2025 | Inventor(s): John Laterra, Amy Fulton

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Oncology > Lung Cancer, Clinical and Disease Specializations > Oncology > Gastric Cancer, Technology Classifications > Therapeutic Modalities > Antibodies

Novel monoclonal antibody inhibitors targeting potassium channel KCNK9

Unmet Need:KCNK9 is one of 15 mammalian subtypes in the highly conserved family of two-pore domain potassium channels (K2P). Under physiological conditions, KCNK9 is primarily expressed in the brain where it serves to maintain cellular membrane potentials. However, overexpression of KCNK9 has been detected in breast, lung, skin, and other cancers, and...

Published: 6/26/2025 | Inventor(s): John Laterra, Han Sun, Min Li, Amy Fulton

Keywords(s): Antibodies, Biologics, Breast Cancer, Cancers, Disease Indication, Lung Cancer, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases, Clinical and Disease Specializations > Women's Health, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Oncology > Lung Cancer

Combination Small Molecule-Chemotherapy for Targeting of Cancer Stem Cells in Drug-resistant Lung Cancer

Value Proposition:· Combination treatment strategy enhances existing chemotherapy treatment regimens to improve long-term survival.· Integration of small molecules with conventional chemotherapy regimens establishes new treatment options for drug-resistant and recurrent lung cancer.· Cancer stem cells (CSCs) are a target in other...

Published: 6/27/2025 | Inventor(s): Mohammad Hoque, Pritam Sadhukhan

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Oncology > Lung Cancer, Clinical and Disease Specializations > Oncology > Adenocarcinoma

Method to Enhance Pulmonary Dendritic Cell-mediated DNA Vaccination

Unmet NeedWith lung diseases, namely influenza and lung cancer, on the rise, pulmonary vaccination is a promising approach to elicit strong immunity to inhaled pathogens and lung cancer compared to systemic immunization strategies. In particular, inhaled DNA vaccination, a rapidly developing field, can potentially promote humoral and cellular immunity...

Published: 6/27/2025 | Inventor(s): Jung Soo Suk, Yoo Chun Kim, Justin Hanes

Keywords(s): Biologics, Cancers, Disease Indication, Drug Delivery Vehicle, Immunotherapy, Infectious Diseases, Influenza, Lung Cancer, Nanoparticles, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Tuberculosis (TB), Vaccine

Category(s): Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB), Clinical and Disease Specializations > Infectious Diseases > Influenza, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Oncology > Lung Cancer, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Vaccines

Low Dose Adjuvant Epigenetic Modifiers Inhibit Cancer Lung Metastases through Disruption of the Myeloid Environment in Pre-metastatic Niches

Unmet NeedCancer recurrence, even following complete surgical resection, remains a large unmet clinical problem. In non-small cell lung cancer (NSCLC) patients, recurrence following surgery remains 30-70%, and the five-year survival rate remains 23% with over 140,000 deaths occurring each year. Recurrence post-surgery can be driven by a number of factors,...

Published: 6/27/2025 | Inventor(s): Malcolm Brock, Zhihao Lu

Keywords(s): Antagonists/Inhibitors, Cancers, Chemotherapy/Chemotherapy, Combination, Disease Indication, Non-novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations > Oncology > Lung Cancer, Technology Classifications > Therapeutic Modalities > Small Molecules

Lung Nodule Malignancy Risk Calculator

Unmet NeedLung cancer is a type of cancer that affects lung tissues and is categorized by the presence of abnormal cell division and rapid growth of lung tissue. Globally, lung cancer is a leading cause of cancer death and poses a major therapeutic burden with poor survival rates. According to estimates from the American Cancer Society, lung cancer...

Published: 6/27/2025 | Inventor(s): Peng Huang, Yuliang Li, Stephen Lam

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology > Lung Cancer

PEGylated Human Heavy Chain Ferritin Nanocages and Their Uses for Therapeutic and Diagnostic Delivery

Unmet Need:Localized delivery of chemotherapeutics to the lung via inhalation provides a straightforward method of directly targeting lung cancers. However, due to the presence of multiple delivery barriers, the effectiveness of the approach has been limited. Here, we disclose an invention of a novel inhalable drug delivery platform capable of...

Published: 6/26/2025 | Inventor(s): Justin Hanes, Jung Soo Suk, Xinglu Huang

Keywords(s): Cancers, Disease Indication, Drug Delivery Vehicle, Lung Cancer, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Lung Cancer, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Glioblastoma Biomarker for Improved Survival Prediction

TITLE: Glioblastoma Biomarker for Improved Survival PredictionCASE NUMBER: C13155UNMET NEEDGlioblastoma GBM), the most common primary brain tumor, has few available therapies providing significant improvement in survival. The median survival of patients after treatment is ~15 months, with only 3-5% surviving longer than 3 years. However, survival varies...

Published: 6/26/2025 | Inventor(s): Patrick Ha, Michael Lim, Chetan Bettegowda, Taeyoung Hwang, Chul-Kee Park, Dimitrios Mathios

Keywords(s): Biomarker, Brain Cancer, Breast Cancer, Cancers, Cervical Cancer, Clinical Diagnostics, Disease Indication, Glioma, In Vitro Diagnostics, Lung Cancer, Prognostic Biomarker

Non-ionizing, Non-invasive, Non-contact, and Real-time Tumor Detection Using Ultra-WideBand (UWB) Radar

C12383: Tumor Detection Using Radar-based Medical ImagingNovelty: A novel tumor-detection technique using Ultra-Wideband (UWB) radar.Value Proposition: UWB is a new technology used in military and commercial remote sensing applications for through-the-wall imaging, identifying hidden features obstructed by walls, concrete, or ground surfaces. This invention...

Published: 6/26/2025 | Inventor(s): Eun Oh, Yeonju Han-Oh

Keywords(s): Cancers, Disease Indication, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Integrated Imaging System, Lung Cancer, Ultra-wide Band Radar (UWB)

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Lung Cancer, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Oncology

Molecular Characteristics of Non-small Cell Lung Cancer

C03957: Molecular Characteristics of Non-small Cell Lung Cancer Technical Details: We used hierarchical clustering to examine gene expression profiles generated by serial analysis of gene expression (SAGE) in a total of nine normal lung epithelial cells and non-small cell lung cancers (NSCLC). Separation of normal and tumor samples, as well as...

Published: 6/26/2025 | Inventor(s): David Sidransky, Mariana Nacht, Stephen Madden, Tatiana Dracheva, Jen Jin

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Lung Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Lung Cancer, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology