Search Results - immunotherapy%2f+immunotherapy

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Administration of DNA Vaccines with DNA Encoding Ii-PADRE Generates Potent PADRE-specific CD4+ T-cell Immune Responses and Enhances Vaccine Potency

Unmet Need: DNA vaccine technology is a desirable antiviral and cancer immunotherapeutic strategy for its simple design and cost-effective implementation. However, current DNA vaccine programs are hindered by poor immunogenicity. Technical Details: Johns Hopkins researchers have designed a novel fusion construct to enhance immunogenicity to DNA vaccines....

Published: 9/26/2024 | Inventor(s): Chien-Fu Hung, T.c. Wu

Keywords(s): Cancers, Combination, Disease Indication, Immunotherapy/ Immunotherapy, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities

Immunoswitch Particles for the Conversion of Inhibitory Signals to Co-stimulatory Signals for Enhanced Immune-mediated Tumor Cell Killing

Unmet Need:One of the largest obstacles to overcome in cancer immunotherapy is the suppressive actions of the tumor microenvironment. Combination therapies that activate an immune response as well as block inhibitory pathways have potential in creating a prolonged and effective anti-tumor response. Technology Overview:Johns Hopkins researchers develop...

Published: 9/26/2024 | Inventor(s): Jonathan Schneck, Alyssa Kosmides Galaro

Keywords(s): Antibodies, Biologics, Cancers, Combination, Disease Indication, Drug Delivery Vehicle, Immunotherapy/ Immunotherapy, Nanoparticles, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Use of Bacteria, Bacterial Products, and other Immunoregulatory Entities in Combination with Anti-CTLA-4 and/or Anti-PD-1 Antibodies to Treat Solid Tumor Malignancies

Combined Therapeutic Method for Solid TumorJHU REF: [C12570]Invention novelty: This technology is a combination therapy method including a tumor-specific bacterium and antibodies that boost tumor immune response.Value PropositionWorldwide cancer affects more than 12 million people each year. This number is expected to increase to 14 million each year...

Published: 9/26/2024 | Inventor(s): Kenneth Kinzler, Bert Vogelstein, KiBem Kim, Shibin Zhou

Keywords(s): Antibodies, Biologics, Cancers, Combination, Disease Indication, Immunotherapy/ Immunotherapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Whole cell

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Immunotherapies