Search Results - linh+tran

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CortiTech

Unmet NeedDeep-seated brain tumors are exceedingly difficult to treat surgically and careful treatment planning is required in order to avoid unintended brain damage during surgery. Currently, about 9% of patients undergoing neurosurgical operations experience surgical complications related to the retractor (a paddle-like tool used to open a working...

Published: 3/14/2025 | Inventor(s): Alan Cohen, Kevin Tu, Rohith Bhethanabotla, Jody Mou, Sun Jay Yoo, Rajiv Iyer, Daniel Rosenthal Garber, Callie Deng, Linh Tran, Jack Ye, Wataru Ishida, Mark Shifman, Ananyaa Sivakumar, Rene DeBrabander, Reena Elizebath

Keywords(s): Balloons, CNS and Neurological Disorders, Dilators/Retractors, Disease Indication, Interventional and Surgical Systems, Surgical Instruments

Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices > Surgical

Supramolecular Hydrogels Containing Angiotensin Receptor Blockers for Targeted Treatment of Diabetic Wounds

Unmet Need: Dysregulation in the renin-angiotensin system (RAS) has been increasingly implicated in abnormal diabetic wound healing. The effect of angiotensin receptor blockers in a wounded subject can be harmful during the early stages of wound healing; however, use of angiotensin receptor blockers during the later proliferative and remodeling stages...

Published: 3/13/2025 | Inventor(s): Honggang Cui, Jeremy Walston, Peter Abadir, Ran Lin

Keywords(s): Drug Delivery Vehicle, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Self-Assembling Verteporfin Amphiphiles (SAVA) for Local Cancer Therapy

Unmet Need: Brain tumors including aggressive Glioblastoma (GBM) remain a large societal burden due to the large number of affected patients and overall poor survival rates. A promising FDA-approved drug verteporfin (VP) was identified that directly targets transcription factors upregulated in GBM, but practical use of this drug to treat GBM is limited...

Published: 3/13/2025 | Inventor(s): Sagar Shah, Juan Carlos Martinez-Gutierrez, Alejandro Ruiz-Valls, Ran Lin, Honggang Cui, Alfredo Quinones-Hinojosa

Keywords(s): Brain Cancer, Cancers, Disease Indication, Drug Delivery Vehicle, Hydrogel, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology > Brain Cancer, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

A p105-based NF-(kappa) B Super repressor

C04290: A p105-based NF-(kappa) B Super repressor Technical Details: Nuclear factor (NF)-kB is a family of transcription factors that regulate immune and inflammatory responses, programmed cell death (apoptosis), and developmental processes. In normal cells, NF-kB is latent, and is activated transiently by stimuli and stresses. However, under pathological...

Published: 3/13/2025 | Inventor(s): Li Lin

Keywords(s): Biologics, Cancers, Chemotherapy, Disease Indication, Nucleic Acid, Single, Skin Cancer, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Dermatology, Clinical and Disease Specializations > Oncology > Skin Cancer, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities