Search Results - petros+karakousis

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A DNA Vaccine for Eliciting T Cell Immunity in the Lung

Unmet NeedRespiratory pathogens are a major contributor to global economic and public health crises. In the wake of the COVID-19 pandemic, new vaccine technologies have been developed to improve the response to emerging pathogens. However, questions remain regarding how to deal with pathogens that have the potential to cause future pandemics. New vaccination...

Published: 7/5/2024 | Inventor(s): Richard Markham, James Gordy, Petros Karakousis

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > Covid-19, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB), Technology Classifications > Therapeutic Modalities > Vaccines

A Vaccine to Reduce Treatment Time for Tuberculosis

Unmet NeedTuberculosis (TB) is one of the leading causes of death globally. A vaccine to prevent TB has not been approved since the development of the BCG vaccine in the early 20th century. New treatment paradigms using small molecule antibiotics have led to cures in a large proportion of individuals with drug-susceptible TB. The course of treatment...

Published: 7/5/2024 | Inventor(s): Richard Markham, Petros Karakousis, Styliani Karanika, James Gordy, Yu-Min Chuang

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > Tuberculosis, Technology Classifications > Therapeutic Modalities > Vaccines, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB)

Guinea Pig-passaged H37Rv rel Mtb Mutant, rel Complement Strain, rel Tetracycline-inducible Knock-in Strain, rel Tetracycline-inducible Knock-down Strain

C11518: Transgenic rel Tubercle Bacilli for Anti-Tuberculosis Drug ScreeningNovelty: Transgenic guinea pig-passaged tubercle bacilli with modified rel expression levels useful for the identification of novel anti-tuberculosis therapeutics.Value Proposition: To date, tuberculosis (TB) infections are often unrecognized due to the ability of tubercle bacilli...

Published: 7/4/2024 | Inventor(s): Petros Karakousis

Keywords(s): Bacterial Infections, Basic Research Biomarker, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Infectious Diseases, Knock Out Rabbit Model, Rabbit Model, Tuberculosis (TB)

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB)