Search Results - plasmid%2fvector

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Formulation Method and Use of Highly Stable Biodegradable Gene Vector Platforms Capable of Overcoming Various Biological Barriers

JHU researchers have formulated compact, colloidally stable gene carriers that have a dense surface coverage of hydrophilic and neutrally charged PEG. These gene vectors stably retain their physicochemical characteristics over at least a week in aqueous solution and are highly stable in physiological solutions. Moreover, they demonstrate the ability...

Published: 3/13/2025 | Inventor(s): Panagiotis Mastorakos, Jung Soo Suk, Justin Hanes

Keywords(s): Biologics, Drug Delivery Vehicle, Gene Therapy, Nucleic Acid, Plasmid/Vector, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

scAAV.EF1a.miR26a.eGFP Plasmid

C10912: A plasmid to produce recombinant adeno-associated virus (AAV) that expresses microRNA-26a and green fluorescent proteinValue Proposition: • miR-26a, cloned into the short intron that is part of the EF1a promoter unit, thus allowing simultaneous production of eGFP and miR-26a from a single transcript • efficient expression of both...

Published: 3/13/2025 | Inventor(s): Erik Wentzel, K. Clark, Janaiah Kota, Jerry Mendell, Kathryn Mendell, Raghu Chivukula, Joshua Mendell

Keywords(s): Cancers, Disease Indication, Drug Delivery Vehicle, Gene Therapy, Liver Cancer, Plasmid/Vector, Single, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Hepatology, Clinical and Disease Specializations > Oncology > Liver Cancer, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools > Vectors & Plasmids

PSMA-retargeted adenovirus

C11155: Method of developing targeted therapeutic agents for cancer using adenovirusValue Proposition: • Addresses a major patient need. • Specific for the target. • Enhances adenoviral gene therapy. • Has therapeutic and diagnostic applications. Technical Details: JHU scientists have developed a successful strategy to optimize targeted...

Published: 3/13/2025 | Inventor(s): Ping Wu, Ronald Rodriguez, Shawn Lupold

Keywords(s): Antigens, Biologics, Cancers, Disease Indication, Drug Delivery Vehicle, Plasmid/Vector, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Host Defense Turned Viral Offense; Engineering the Next Generation of Oncolytic Adenoviruses

C10910: Use of RNA Interference and Adenovirus Therapy against Prostate CancerValue Proposition: • Addresses a major patient need • Enhances the therapeutic efficacy of CRAd strategy • Creates the bases to develop enhanced oncolytic viral gene therapies with shRNA Technical Details: Prostate cancer is one of the most aggressive cancers...

Published: 3/13/2025 | Inventor(s): Naser Hoti, Ronald Rodriguez

Keywords(s): Biologics, Cancers, Cell Therapy/Immunotherapy, Combination, Disease Indication, Drug Delivery Vehicle, Nucleic Acid, Plasmid/Vector, Prostate Cancer, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities