Search Results - joshua+mendell

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MicroRNA Delivery as a Novel Therapeutic Strategy for Liver Cancer

Unmet needOver 500,000 people are diagnosed with liver cancer worldwide each year. According the American Cancer Society, liver cancer resists most chemotherapy drugs and the most effective agents shrink less than 1 in 5 tumors and generally for only a short time. Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage making it difficult...

Published: 6/20/2024 | Inventor(s): Kathryn Mendell, Raghu Chivukula, Janaiah Kota, Erik Wentzel, Jerry Mendell, K. Clark, Joshua Mendell

Keywords(s): Biologics, Cancers, Disease Indication, Gene Therapy, Liver Cancer, Nucleic Acid, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Hepatology, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Liver Cancer

miR-143/145 conditional knockout mice

Unmet NeedThe miR-143/145 microRNA cluster has been implicated in colon cancer and other epithelial tumors, but investigation of its role in pathogenesis requires a research tool in which miR-143/145 expression can be modulated in specific cell types. Technology OverviewJohns Hopkins researchers generated a conditional knockout allele for the miR-143/145...

Published: 6/20/2024 | Inventor(s): Joshua Mendell, Raghu Chivukula, Guanglu Shi

Keywords(s): Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Animal Models

scAAV.EF1a.miR26a.eGFP Plasmid

C10912: A plasmid to produce recombinant adeno-associated virus (AAV) that expresses microRNA-26a and green fluorescent proteinValue Proposition: • miR-26a, cloned into the short intron that is part of the EF1a promoter unit, thus allowing simultaneous production of eGFP and miR-26a from a single transcript • efficient expression of both...

Published: 6/20/2024 | Inventor(s): Erik Wentzel, K. Clark, Janaiah Kota, Jerry Mendell, Kathryn Mendell, Raghu Chivukula, Joshua Mendell

Keywords(s): Cancers, Disease Indication, Drug Delivery Vehicle, Gene Therapy, Liver Cancer, Plasmid/Vector, Single, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Hepatology, Clinical and Disease Specializations > Oncology > Liver Cancer, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools > Vectors & Plasmids

MicroRNAs As Targets for Anti-Angiogenic Therapies

C05032: MicroRNAs As Targets for Anti-Angiogenic Therapies Technical Details: MicroRNAs (miRNAs) are 18-24 nucleotide RNA molecules that regulate the stability or translational efficiency of target mRNAs. miRNAs are frequently dysregulated in cancer cells and can act as oncogenes and tumor-suppressors. The proto-oncogene c-MYC encodes a transcription...

Published: 6/20/2024 | Inventor(s): Michael Dews, Asal Homayouni, Erik Wentzel, Andrei Thomas-Tikhonenko, Joshua Mendell

Keywords(s): Biologics, Cancers, Disease Indication, Gene Therapy, Nucleic Acid, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools > Nucleic Acids