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Personalized Care for Patients with Retinal Diseases

Unmet NeedAccording to the National Institute of Health, neovascular (wet) age-related macular degeneration (nAMD) is the most common cause of visual impairment among elderly patients in developed countries, and is predicted to increase globally from 196 million patients in 2020 to 288 million by 2040. Our current management of nAMD has two major limitations....

Published: 6/28/2024 | Inventor(s): Tin Yan Liu, Craig Jones

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Computers, Electronics & Software > Machine Learning, Clinical and Disease Specializations > Ophthalmology > Age-Related Macular Degeneration

Augmented or Virtual Reality Based Evaluation of Visual Field

Sensitive visual field assessment using augmented realityJHU Ref #: C17601Unmet NeedWhile visual field measurement is key in diagnosing and monitoring eye and systemic diseases in patients (American Academy of Ophthalmology, 2022), current practices are either quick but imprecise (confrontation visual field tests that rely on the doctor’s hand gestures...

Published: 6/28/2024 | Inventor(s): Ali Saber Tehrani, Arash Saber Tehrani

Keywords(s):

Category(s): Clinical and Disease Specializations > Ophthalmology, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Machine Learning

OpenCRAVAT, An Open Source Collaborative Platform for the Annotation of Human Genetic Variation

Unmet NeedGene variants are complex to interpret, involving different published methods, databases, algorithms for ranking genes and different prediction tools. Decision support frameworks were created to integrate these various resources into one environment. However, current frameworks are limited by a closed proprietary architecture, limiting its...

Published: 6/28/2024 | Inventor(s): Rachel Karchin, Kymberleigh Pagel, Michael Ryan, Rick Kim, Kyle Moad

Keywords(s): Computer and Network Systems, Computer Software, Database Management Software

Category(s): Technology Classifications > Computers, Electronics & Software > Databases, Technology Classifications > Computers, Electronics & Software > Algorithms, Clinical and Disease Specializations > Genetic Diseases, Clinical and Disease Specializations > Oncology

Acoustic Frequency-Based Spectral Unmixing to Determine Tissue Constituents

Unmet Need:The demarcation between target tissue to be removed, and healthy tissue to leave intact, is critical to the success of any surgical procedure. These operations are often performed using high-resolution imaging, including MRI or CT scans. Such methods provide a priori information to clinicians; however, these methods yield limited information...

Published: 6/28/2024 | Inventor(s): Muyinatu Bell, Eduardo Gonzalez

Keywords(s):

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices > Surgery, Technology Classifications > Research Tools > Imaging, Technology Classifications > Computers, Electronics & Software > Algorithms, Clinical and Disease Specializations > Surgery

Multiple X-ray Focal Spots for High-Resolution CT

JHU Ref #: C17539Unmet Need· High spatial resolution CT has many clinical applications, including identification of small fractures and visualization of internal organ structures. · Improved spatial resolution of a CT scan has been limited by several factors, including the size of the x-ray source focal spot, x-ray tube power, detector...

Published: 6/28/2024 | Inventor(s): Joseph Stayman, Jianan Gang, Peter Noel

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Algorithms

Antibody Structure Prediction from Pre-trained Language Model (IgFold)

Inventor(s): Jeffrey Ruffolo and Jeffrey Gray Unmet Need: Antibodies are able to bind a diverse set of antigens and have become critical therapeutics and diagnostic molecules. Antibody binding is facilitated by a set of six hypervariable loops that are diversified through genetic recombination and mutation. An accurate structural model of the hypervariable...

Published: 6/28/2024 | Inventor(s): Jeffrey Gray, Jeffrey Ruffolo

Keywords(s):

Category(s): Copyright, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Research Tools > Antibodies

Machine Learning Algorithm for Delirium Prediction in the Intensive Care Unit

Unmet NeedDelirium is a potentially preventable and often reversible disorder of impaired cognition. It is common in the intensive care unit (ICU), with an overall prevalence of 32.3%. However, the prevalence is dependent on the type of patients. For example, among ventilated burn patients, the prevalence is 77%, and among mechanically ventilated patients,...

Published: 6/28/2024 | Inventor(s): Robert Stevens, Kirby Gong, Akaash Sanyal, Joanna Guo, Ryan Lu, Teya Bergamaschi, Han Kim

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology > Dementia, Clinical and Disease Specializations > Neurology > Cognitive Impairment, Clinical and Disease Specializations > Neurology, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Diagnostics > Prognostic Biomarkers

A System for the Automated Classification of Disease Tissue in Molecular Imaging Studies utilizing Convolutional Neural Networks with User-Selectable Sensitivity and Specificity

Unmet NeedMedical imaging is an important diagnostic tool used for the detection of a wide array of clinical conditions. The application of Artificial Intelligence (AI) and Deep Learning (DL) is being developed to assist medical imaging professionals manage the ever-growing number of images which they must interpret in their research and clinical practice....

Published: 6/28/2024 | Inventor(s): Jeffrey Leal

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Medical Devices > Imaging

CloneRetriever: An Automated Algorithm to Identify B-cell and T-cell Gene Rearrangements by Next-Generation Sequencing

Unmet NeedIn the U.S., there are an estimated 1,297,027 people living with blood cancers (leukemia, lymphoma or myeloma), with an additional 178,520 people expected to be diagnosed each year (see Leukemia & Lymphoma Society). Diagnostics tools that utilize next-generation sequencing (NGS) technologies are often performed to identify gene rearrangements...

Published: 6/28/2024 | Inventor(s): Rena Xian, Eitan Halper-Stromberg, Richard Ambinder

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > Prognostic Biomarkers

Quantitative Human Motion Analysis using Video-based Pose Estimation

Unmet NeedHuman gait analysis is now common in many fields of clinical and basic research, but gold standard approaches – e.g., three-dimensional motion capture, instrumented mats or footwear, and wearables – are often expensive, immobile, data-limited, and/or require specialized equipment or expertise for operation, furthermore limiting the access...

Published: 6/28/2024 | Inventor(s): Ryan Roemmich, Jan Stenum

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology > Multiple Sclerosis, Clinical and Disease Specializations > Neurology > Parkinson’s Disease, Clinical and Disease Specializations > Neurology > Stroke, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > Diagnostic Imaging

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