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Predictive Algorithms for MISKD Clinical Decision Support System

Unmet NeedChildren hospitalized with SARS-Cov-2 infection are at risk for two similar inflammatory syndromes: Kawasaki disease (KD), and multi-system inflammatory syndrome in children (MIS-C). However, current clinical diagnostic standards for these two conditions have considerable overlap, which can lead to misdiagnosis and suboptimal treatment and...

Published: 6/27/2025 | Inventor(s): Cedric Manlhiot, Bhargava Kumar Chinni, Shelby Kutty

Keywords(s):

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Clinical and Disease Specializations > Infectious Diseases > Covid-19, Clinical and Disease Specializations > Inflammation

Accelerating Numerical Methods with AI-Based Surrogate Models

Value Proposition: Efficient modeling of dynamic phenomena with negligible error rates below 1% Reduced computational demand, not dependent on large datasets Utility across different domains and scalable to multiscale challenges Applicable to life sciences, material science, and engineering sectors Unmet Need: Accurate modeling of material...

Published: 6/27/2025 | Inventor(s): Somdatta Goswami, Wei Wang

Keywords(s):

Software Tools for Tomographic Reconstruction

Value Proposition· Superior Image Quality – the proposed nonlinear DPS method outperforms traditional reconstruction methods and linear DPS models, offering better high-quality images across different acquisition protocols compared to conditionally trained deep learning approaches· State-of-the-Art Reconstruction – cutting-edge implementations...

Published: 6/27/2025 | Inventor(s): Joseph Stayman, Xiao Jiang, Shudong Li, Altea Lorenzon, Peiqing Teng

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis

A System and Method for Real-Time Ventricular Arrhythmia Localization and Catheter Navigation Using Surface ECG

Unmet NeedVentricular arrhythmias (VAs) are common arrhythmias associated with morbidity, mortality, and impaired quality of life. The current treatment for VAs is a catheter ablation procedure. This procedure is considered moderately successful at best and the success rate dramatically increases when the ablation is performed by experienced operators....

Published: 6/27/2025 | Inventor(s): Konstantinos Aronis, Ronald Berger, Natalia Trayanova, Shijie Zhou, Harikrishna Tandri

Keywords(s): Arrhythmias, Cardiovascular Diseases, Disease Indication, Image Display Software, Image Processing Software, Imaging and Sensing Systems, In Vivo Medical Imaging, Interventional and Surgical Systems, Surgical Navigation, Tracking Software

Category(s): Clinical and Disease Specializations > Cardiovascular > Arrhythmia, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices > Cardiology

Personalized Care for Patients with Retinal Diseases

Unmet NeedAccording to the National Institute of Health, neovascular (wet) age-related macular degeneration (nAMD) is the most common cause of visual impairment among elderly patients in developed countries, and is predicted to increase globally from 196 million patients in 2020 to 288 million by 2040. Our current management of nAMD has two major limitations....

Published: 6/27/2025 | Inventor(s): Tin Yan Liu, Craig Jones

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Computers, Electronics & Software > Machine Learning, Clinical and Disease Specializations > Ophthalmology > Age-Related Macular Degeneration

Augmented or Virtual Reality Based Evaluation of Visual Field

Sensitive visual field assessment using augmented realityJHU Ref #: C17601Unmet NeedWhile visual field measurement is key in diagnosing and monitoring eye and systemic diseases in patients (American Academy of Ophthalmology, 2022), current practices are either quick but imprecise (confrontation visual field tests that rely on the doctor’s hand gestures...

Published: 6/27/2025 | Inventor(s): Ali Saber Tehrani, Arash Saber Tehrani

Keywords(s):

Category(s): Clinical and Disease Specializations > Ophthalmology, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Machine Learning

OpenCRAVAT, An Open Source Collaborative Platform for the Annotation of Human Genetic Variation

Unmet NeedGene variants are complex to interpret, involving different published methods, databases, algorithms for ranking genes and different prediction tools. Decision support frameworks were created to integrate these various resources into one environment. However, current frameworks are limited by a closed proprietary architecture, limiting its...

Published: 6/27/2025 | Inventor(s): Rachel Karchin, Kymberleigh Pagel, Michael Ryan, Rick Kim, Kyle Moad

Keywords(s): Computer and Network Systems, Computer Software, Database Management Software

Category(s): Technology Classifications > Computers, Electronics & Software > Databases, Technology Classifications > Computers, Electronics & Software > Algorithms, Clinical and Disease Specializations > Genetic Diseases, Clinical and Disease Specializations > Oncology

Acoustic Frequency-Based Spectral Unmixing to Determine Tissue Constituents

Unmet Need:The demarcation between target tissue to be removed, and healthy tissue to leave intact, is critical to the success of any surgical procedure. These operations are often performed using high-resolution imaging, including MRI or CT scans. Such methods provide a priori information to clinicians; however, these methods yield limited information...

Published: 6/27/2025 | Inventor(s): Muyinatu Bell, Eduardo Gonzalez

Keywords(s):

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices > Surgery, Technology Classifications > Research Tools > Imaging, Technology Classifications > Computers, Electronics & Software > Algorithms, Clinical and Disease Specializations > Surgery

Multiple X-ray Focal Spots for High-Resolution CT

JHU Ref #: C17539Unmet Need· High spatial resolution CT has many clinical applications, including identification of small fractures and visualization of internal organ structures. · Improved spatial resolution of a CT scan has been limited by several factors, including the size of the x-ray source focal spot, x-ray tube power, detector...

Published: 6/27/2025 | Inventor(s): Joseph Stayman, Jianan Gang, Peter Noel

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Algorithms

Antibody Structure Prediction from Pre-trained Language Model (IgFold)

Inventor(s): Jeffrey Ruffolo and Jeffrey Gray Unmet Need: Antibodies are able to bind a diverse set of antigens and have become critical therapeutics and diagnostic molecules. Antibody binding is facilitated by a set of six hypervariable loops that are diversified through genetic recombination and mutation. An accurate structural model of the hypervariable...

Published: 6/27/2025 | Inventor(s): Jeffrey Gray, Jeffrey Ruffolo

Keywords(s):

Category(s): Copyright, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Research Tools > Antibodies

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