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Long Term Storage and Improved Mechanical Properties of Implantable Vascular Grafts

Technical ProblemCurrent synthetic small-diameter tissue engineered vascular grafts face challenges such as thrombogenicity, decreased elasticity, aneurysmal failure, calcification, and intimal hyperplasia, limiting their clinical effectiveness for pediatric congenital cardiovascular defects, coronary artery disease, and peripheral artery disease, while...

Published: 2/5/2026 | Inventor(s): Sharon Gerecht, Morgan Elliott, Hai-Quan Mao, Jessica Shen

Keywords(s):

Category(s): Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Therapeutic Modalities > Tissue Substrates, Technology Classifications > Medical Devices > Cardiology

A Novel-fate Marking Strategy to Permanently Tag Hypoxic Cancer Cells

Value Proposition· Permanently labels cells that have experienced hypoxia, enabling long-term tracking· Captures tumor evolution by identifying cells with past hypoxia exposure, not just at the time of tissue collection· Enables investigation of metastasis by tracking cells from hypoxic niches that may retain aggressive phenotypes· Supports...

Published: 2/5/2026 | Inventor(s): Daniele Gilkes, Ines Godet

Keywords(s): Breast Cancer, Cancers, Cardiovascular Diseases, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, In Vivo Research Tool, Mouse Model, Translational Research Biomarker

Category(s): Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines

System and Method for Optimization and Planning of Cardiac Surgery

Value Proposition:· Customizes vascular grafts for each patient’s anatomy and hemodynamically optimizes them.· Combines advanced computational methods with surgeons’ clinical expertise.· Enables physicians to iteratively prototype, evaluate, and optimize graft designs through a user-friendly process, significantly reducing surgical...

Published: 2/5/2026 | Inventor(s): Narutoshi Hibino, Axel Krieger, Xiaolong Liu, Byeol Kim, Mark Fuge, Phong Nguyen, Rachel Hess, Pratham Nar, Laura Olivieri, Yue-Loke Hin, Paige Mass, Seda Aslan

Keywords(s):

Category(s): Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Medical Devices > Surgery, Technology Classifications > Computers, Electronics & Software > Clinical Management

Volumetric Interventional Tool Tracking and Patient Monitoring Method and Apparatus

Unmet NeedUltrasound-guided vascular access has also been shown to decrease cannulation time for emergent veno-arterial extracorporeal membrane oxygenation (VA-ECMO) cannulation in refractory cardiac arrest. Despite the increasingly widespread use of ultrasound for procedural guidance, reliable and accurate tracking of the device can be challenging...

Published: 2/5/2026 | Inventor(s): Jeeun Kang, Emad Boctor, Laeben Lester, Keshuai Xu, Jintan Zhang

Keywords(s):

Category(s): Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Medical Devices > Cardiology, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Computers, Electronics & Software

A Novel and Unique Set of Human Antibodies to Human Resistin and to Human Resitin-like Molecule Beta (RELMB) that can be used to Target these Proteins in Human Disease

Unmet NeedAutoinflammatory responses, your body’s innate defense mechanism against infections and stressors, can become overactive and cause chronic inflammation in various tissues and organs. Inflammatory diseases affect more than 200 million people worldwide and include pulmonary hypertension, scleroderma, rheumatoid arthritis, pulmonary fibrosis,...

Published: 2/5/2026 | Inventor(s): Roger Johns

Keywords(s): Antibodies, Biologics, Cardiovascular Diseases, Disease Indication, Hypertension, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Cardiovascular > Hypertension

Diagnostic and therapeutic target for primary dysautonomia

Value Proposition:· Diagnostic target for broad primary dysautonomia screening.· Broadly applicable therapeutic target for symptom relief in primary and secondary dysautonomia patients.Technology DescriptionResearchers at Johns Hopkins have identified a potential diagnostic and therapeutic target for patients with primary dysautonomia....

Published: 2/5/2026 | Inventor(s): Malcolm Brock, Frank Bosmans

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Therapeutic Modalities, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities > Small Molecules

Alkylsulfenyl Thiocarbonates as Precursors to Hydropersulfides

Unmet Need:According to a survey by the CDC, nearly 50% of Americans age 20 and up have some form of cardiovascular disease (see AHA). The management of cardiovascular diseases depends on the specific indication, and standard therapies include one or multiple of the following types of medications: blood thinners, ACE inhibitors, beta-blockers, calcium...

Published: 2/5/2026 | Inventor(s): John Toscano, Vinayak Khodade, Sahil Aggarwal, Nazareno Paolocci, Blaze Pharoah, Gizem Keceli, Kelsey Zhang

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Cardiovascular, Clinical and Disease Specializations > Oncology

Regeneration of cardiac muscle for the treatment of heart failure

Value Proposition:This technology provides a therapeutic approach for the regrowth of permanently damaged heart muscle.This could improve health outcomes for patients with severe heart failure.Technology DescriptionResearchers at Johns Hopkins have discovered that the manipulation of circadian genes can induce the proliferation and regeneration of cardiomyocytes...

Published: 2/5/2026 | Inventor(s): Emmanouil Tampakakis

Keywords(s):

Category(s): Clinical and Disease Specializations > Cardiovascular, Clinical and Disease Specializations > Cardiovascular > Heart Failure, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Targets

Apparatus and method for multiparameteric wearable continuous vital signs and blood pressure measurement

Technology Description· Researchers at Johns Hopkins have developed a wearable patch that continuously monitors blood pressure and cerebral blood flow.· The device harnesses photoacoustic imaging, pairing LED lights with ultrasonic detectors to monitor flow even in small vessels. · The device simultaneously measures clinical data...

Published: 2/5/2026 | Inventor(s): Brian Bush, Emad Boctor, Laeben Lester

Keywords(s):

Category(s): Technology Classifications > Medical Devices > Cardiology, Technology Classifications > Medical Devices, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Cardiovascular

Biopolymer Encapsulation Increases the Bioavailability and Efficacy of D-PDMP in Interfering with Atherosclerosis and Cardiac Hypertrophy in apoE-/- Transgenic Mice

INVENTION NOVELTYA novel glycolipid inhibitor anti-atherosclerosis drug compound able to enhancegastro-intestinal absorption and residence time to reduce and ameliorateeffects of arteriosclerosis VALUE PROPOSITIONDespite great success of statins (cholesterol reducing agents), little is known aboutother molecules such as glycolipids that also rise with...

Published: 2/5/2026 | Inventor(s): Subroto Chatterjee

Keywords(s): Antagonists/Inhibitors, Cardiovascular Diseases, Disease Indication, Drug Delivery Vehicle, Non-novel, Off-the-shelf, Polymers, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

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