Search Results - clinical+and+disease+specializations+%3e+neurology+%3e+itch

3 Results

Sort By:

C13783 - Pirt-Cre Mice

Invention novelty: JHU researchers have generated generated Pirt-Cre mice in which Cre recombinase is expressed specifically in all primary sensory neurons in dorsal root ganglion (DRG) under the control of Pirt promoter. Value Proposition:Primary sensory neurons in dorsal root ganglion (DRG) play essential role in initiating, transmitting, and modulating...

Published: 9/26/2024 | Inventor(s): Xinzhong Dong

Keywords(s): Basic Research Biomarker, Chronic Pain, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Itch, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Itch

Pirt-GCaMP3 Mice

Invention novelty: Primary sensory neurons in the DRG play essential role in initiating somatosensory such as pain, itch, and touch by directly sensing various sensory stimuli like mechanical, chemical, and thermal stimuli. Dysfunction of these neurons often leads to various pathological conditions including chronic pain and itch. Currently, no one...

Published: 9/26/2024 | Inventor(s): Xinzhong Dong

Keywords(s): Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Itch, Knock In Mouse Model, Mouse Model, Neuropathy

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Itch, Clinical and Disease Specializations > Neurology > Neuropathy

Chloroquine-induced Itch is Mediated by Mrgs

C10519: Methods and Compositions for Treating Itch Value Proposition: Inventors have identified a cell receptor family known as Mrgprs that is exclusively expressed in a small subset of neurons. In vitro and animal studies suggest that the Mrg receptor family directly mediates chloroquine (CQ) induced itch. Identification and characterization of Mrgprs...

Published: 9/26/2024 | Inventor(s): David Anderson, Qin Liu, Xinzhong Dong

Keywords(s): Biomarker, CNS and Neurological Disorders, Disease Indication, Infectious Diseases, Inflammatory Disorders, Itch, Malaria, Mechanism of Action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Inflammation, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Neurology > Itch