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MMSET Knock Out and Knock Down Multiple Myeloma Cells

C10575: MMSET Knock Out and Knock Down Multiple Myeloma Cells Value Proposition: • Effective knockout/knockdown Multiple Myeloma cells line for the study of t(4;14)(p16;q32), worst prognostic subgroup in Multiple Myeloma Patients. Technical Details: Multiple myeloma (MM) is an incurable hematologic malignancy characterized by recurrent chromosomal...

Published: 3/13/2025 | Inventor(s): Josh Lauring, Ben Ho Park

Keywords(s): Basic Research Biomarker, Blood Cancer, Cancer Cells, Cancers, Cell Model, Discovery/Research Tools, Disease Indication, Hematologic Malignancies, In Vitro Research Tool, Multiple Myeloma

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Hematology, Clinical and Disease Specializations > Oncology > Hematologic Malignancies, Clinical and Disease Specializations > Oncology > Multiple Myeloma, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines

SOCS1 Promoter Methylation Identifies a Target for JAK/STAT Activation

C03870: Identification and treatment of cancers with epigenetic silencing of SOCS/CIS genes.Value Proposition: • Methods for early detection, progression, and recurrence of hematological malignancies • Predictive biomarker useful for determining sensitivity to JAK inhibitors • Methods to aid in risk assessment of primary and secondary...

Published: 3/13/2025 | Inventor(s): Curtis Harris, Hirohide Yoshikawa, James Herman

Keywords(s): Biologics, Biomarker, Blood Cancer, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Discovery/Research Tools, Disease Indication, Gene Therapy, Hematologic Malignancies, In Vitro Diagnostics, In Vitro Research Tool, Multiple Myeloma, Protein, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Hematology, Clinical and Disease Specializations > Oncology > Hematologic Malignancies, Clinical and Disease Specializations > Oncology > Multiple Myeloma, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Biologics