Search Results - henry+brem

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Systems and Methods for Automatic Detection and Localization of Foreign Body Objects during (and after) Neurosurgery

Unmet Need· Retained foreign bodies (RFBs) are remnant materials following neurosurgery, often imperceptible cotton tufts, that can lead to neurological impairment and textilomas (Bechtold et al 2020). The incidence is estimated to be as high as 1 in 100 operations, and cost hospitals millions in healthcare costs and litigation (Whang et al....

Published: 3/14/2025 | Inventor(s): Amir Manbachi, Haley Abramson, Judy Huang, Henry Brem, Nicholas Theodore, George Coles

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Surgery, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Research Tools > Surgical, Technology Classifications > Computers, Electronics & Software > Machine Learning

Polymer-based Acriflavine Wafers for the Treatment of Malignant Brain Cancer

Value Proposition:· Intracranial wafers deliver anti-cancer drugs directly to the tumor, circumventing pharmacokinetic barriers.· Repurposes acriflavine and polymers, both with other FDA approvals, for malignant glioma.· High-efficacy treatment option to prolong survival for the most common form of aggressive brain cancer.· 10-fold...

Published: 3/13/2025 | Inventor(s): Betty Tyler, Antonella Mangraviti, Henry Brem, Alessandro Olivi, Tula Raghavan

Keywords(s): Brain Cancer, Cancers, Disease Indication, Drug Delivery Mechanism, Drug Delivery Vehicle, Glioma, Non-novel, Polymers, Predicted Novelty, Repurposed, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology > Brain Cancer, Clinical and Disease Specializations > Oncology > Glioma, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Intraoperatively Placed Markers for Post-surgical Imaging

Invention Novelty: A dissolvable polymer implant impregnated with contrast agent to improve anchoring with minimal tissue displacement.Value Proposition:The main limitation of current neuronavigation systems is that they rely on preoperative images for accurate navigation. The brain is susceptible to a phenomenon called brainshift due to CSF leakage...

Published: 3/13/2025 | Inventor(s): Sheng-fu Lo, Jason Liauw, Betty Tyler, Henry Brem, Michael Lim

Keywords(s): Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices