Search Results - mandeep+singh

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Novel stem-cell based therapeutic for retinal and macular repair

Unmet Need / Invention Novelty: Currently, there are limited options for patients diagnosed with degenerative macular diseases, with available options reducing the rate of degeneration rather than repairing the diseased retinal tissue. There is an unmet need to develop a novel therapeutic for macular degenerations that repairs diseased tissue. Technical...

Published: 6/28/2024 | Inventor(s): Mandeep Singh, Robert Johnston, Kiara Eldred, Katarzyna Hussey, Sarah Hadyniak, Christina McNerney

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Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies

Novel universal stem cell-based therapy for the treatment of retinal diseases

Unmet Need / Invention Novelty: Gene augmentation therapy, the current technology for treatment of inherited retinal diseases, is limited by its 1) small cargo capacity which challenges the delivery of larger genes 2) ability to target only a single genetic mutation, and thus disease subtype, at a time, and 3) applicability only to recessive diseases...

Published: 6/28/2024 | Inventor(s): Mandeep Singh, Seth Blackshaw, Robert Johnston, Jiang Qian, Ying Liu

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies

External and internal intraoperative optical coherence tomography imaging for subretinal material delivery

Unmet NeedCompared to intravitreal injection, subretinal injection is a more direct approach for targeting cells in the subretinal space. This novel device and described methodology will provide a new therapeutic technique for treating vitreo-retinal diseases, especially when gene therapy and/or cell therapy are involved. To date, subretinal delivery...

Published: 6/28/2024 | Inventor(s): Jin Kang, Mandeep Singh, Kevin Wolfe, Kathleen Perrino

Keywords(s): Disease Indication, Eye Disorders, Imaging and Sensing Systems, In Vivo Medical Imaging, Integrated Imaging System, Interventional and Surgical Systems, Macular Degeneration, Other, Surgical Intervention Method, Therapeutic Devices, Therapeutics

Category(s): Clinical and Disease Specializations > Ophthalmology > Age-Related Macular Degeneration, Clinical and Disease Specializations > Ophthalmology > Stargardt's Disease, Technology Classifications > Medical Devices > Imaging

Retinal Implantation Device

Unmet NeedMillions of people around the world suffer from retinal degenerative diseases at varying degrees of vision loss. Common to all retinal degenerative diseases is the damage to photoreceptor cells of the retina, which malfunction and disappear. Current treatments can begin with trying to “rescue” remaining photoreceptors. Unfortunately this strategy...

Published: 6/27/2024 | Inventor(s): Mandeep Singh, Kevin Wolfe, Jin Kang, Kathleen Perrino, Andrea Timm

Keywords(s): Disease Indication, Eye Disorders, Implanted Device, Implants, Macular Degeneration, Retinal Degeneration, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices

Category(s): Clinical and Disease Specializations > Ophthalmology > Macular Degeneration, Clinical and Disease Specializations > Ophthalmology > Retinal Degeneration, Technology Classifications > Medical Devices > Regenerative Medicine