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Detection of Cancer in Body Fluids Using Cell Enrichment and Flow Cytometry

Unmet NeedEarly detection of cancer is critical for diagnosis, informing treatment, and improving prognostic outcomes. Solid biopsies can be difficult to obtain and provide limited information on tumor composition. In recent years, liquid biopsies have allowed for non-invasive testing of circulating tumor-derived components, such as tumor cells or nucleic...

Published: 3/14/2025 | Inventor(s): Jonathan Dudley, Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos

Keywords(s):

Category(s): Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Precision Medicine Tools, Technology Classifications > Diagnostics > Companion Diagnostics, Clinical and Disease Specializations > Oncology

A Compressive Ultrahigh-speed Continuous Imager Using Spectrally-structured Ultrafast Laser Pulses

This invention uses chirped processing and electro-optic modulation in optical fiber components to encode unique pseudorandom binary patterns at an ultra-high rate onto the spectra of broadband mode-locked laser pulses. Each laser pulse receives a unique spectral pattern and then serves as an ultrashort burst of structured illumination of an object...

Published: 3/13/2025 | Inventor(s): Mark Foster, Jasper Stroud, Bryan Bosworth, Trac Tran, Sang Chin, Dung Tran

Keywords(s): Clinical Diagnostics, Discovery/Research Tools, Environmental Sensing, Imaging and Sensing Systems, In Vitro Diagnostics, In Vitro Research Tool, Point of Care, Research Instrument

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Precision Medicine Tools, Technology Classifications > Research Tools, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > Diagnostic Imaging

PALB2 Gene Mutations Identify Susceptibility to DNA Damaging Agents

PALB2 Gene Mutations Identify Susceptibility to DNA Damaging AgentsJHU Ref #: C10869Unmet NeedPancreatic cancer is predicted to be the second leading cause of cancer-related death by 2030 (Siegel et al., 2020). However, many patients present with advanced disease, and typical broad-spectrum chemotherapeutic treatments are often insufficient. Precision...

Published: 3/13/2025 | Inventor(s): Ralph Hruban, Bert Vogelstein, Kenneth Kinzler, Victor Velculescu, Scott Kern, Sian Jones, Michael Goggins, Manuel Hidalgo, Alison Klein, James Eshleman, Donald Parsons

Keywords(s): Biomarker, Clinical Diagnostics, In Vitro Diagnostics, Risk Stratification

Category(s): Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Diagnostics > Precision Medicine Tools