Search Results - clinical+and+disease+specializations+%3e+immuno-oncology

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Detection of cancers from cfDNA using novel epigenetic instability-based metrics

Value Proposition:· Uses methylation-based epigenetic instability as a biomarker for cancer detection· Target specific and/or target agnostic capabilities to detect cancer· Outperforms existing technologies of DNA methylation-based cancer diagnostics· Can be used in combination with current approaches/diagnostics to increase...

Published: 3/14/2025 | Inventor(s): Hariharan Easwaran, Sara-Jayne Thursby, Zhicheng Jin, Malcolm Brock, Stephen Baylin

Keywords(s):

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Oncology

Nanomaterial Vaccine that Activates Tumor Killing Gamma Delta T Cells: A Novel Therapy for Cancer

Value Proposition:· Significant cost savings and time savings compared to standard adoptive T cell therapies· Improved accessibility for patients who cannot reach treatment centers offering adoptive T cell therapies· Direct tumor targeting, limiting systemic clearance and minimizing off-target toxicity.· Increased drug loading ratios...

Published: 3/14/2025 | Inventor(s): David Wilson, Sabrina Chen

Keywords(s):

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Oncology

Antitumor drug interrupting glucose metabolism as a therapeutic strategy for cancer

Value Proposition:· Drug reduces tumor burden by interrupting cancer cells’ reliance on glucose metabolism.· Tolerated by healthy, normal cells.· Potential for combination therapy with other modalities (chemotherapy, radiation, immunotherapy, etc.)Unmet Need· Cancer is the leading cause of death globally, and it’s estimated that...

Published: 3/14/2025 | Inventor(s): Ling He

Keywords(s):

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Nanoparticles for Delivery of Immunoregulatory Materials to T Cells

Value Proposition:· This platform improves current methods for expansion of CD4+ T-cells, which could be used in adoptive transfer therapies.· Improves modulation, activation, and expansion of T cells over current methods used for CAR T-cell therapyTechnology Description· Researchers at Johns Hopkins have developed a nanoparticle-based...

Published: 3/14/2025 | Inventor(s): Jonathan Schneck, Ariel Isser, Si-Sim Kang

Keywords(s):

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Oncology, Technology Classifications > Engineering Tech, Technology Classifications > Therapeutic Modalities

Compositions of Kinetic Nanoparticles containing Nucleic Acids, Polycations, and Lipids with Defined Sizes, and Methods of Producing the Same

Value Proposition:· Scalable, efficient, and tunable nanoparticle creation technique that can deliver a variety of payloads· Polymer-lipid nanoparticles are biodegradable and are being tested for immunogenicity· Can be used for in vivo gene therapy delivery as well as in vitro cell transfection and research applications Technology...

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Stephany Tzeng, Jordan Green, Yizong Hu, Sashank Reddy, Leonardo Cheng

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VR-Expressing Cells against Multiple Cytokines and Uses Thereof

Unmet Need· Recent technological breakthroughs have highlighted the therapeutic potential of immunotherapy (e.g., CAR-T cells) and have focused attention and efforts on developing safe and effective immunotherapy modalities.· Despite advances in the field, there remain several challenges to both efficacy and safety of CAR-T and other immunotherapies.· CAR-T...

Published: 3/14/2025 | Inventor(s): Adrian Johnston, Denis Wirtz

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Immunotherapies, Clinical and Disease Specializations > Immuno-Oncology

Preparation and Use of a Conjugate of Anti-CD47 Antibody and Toll-like Receptor Agonist

Unmet NeedCancer treatment is an ongoing endeavor across the globe and there have been many milestones achieved recently in successfully treating cancer, such as immunotherapy and gene therapies. The current gold standards for the treatment of blood cancers include chemotherapy, radiation, stem cell transplants, surgery, and immunotherapy. Each of the...

Published: 3/14/2025 | Inventor(s): Jung Soo Suk, Seungwoo Chung, Yunxuan Xie

Keywords(s):

Category(s): Clinical and Disease Specializations > Immuno-Oncology

Engineered Extracellular Vehicles as a selective drug delivery platform

Value Proposition:· Engineered extracellular vesicles with enhanced uptake and reduced immunogenicity · Improved EV-based drug delivery platform Technology DescriptionResearchers at Johns Hopkins have identified endogenous proteins that can be engineered to assist in extracellular vesicle and/or nanoparticle therapeutics through increased...

Published: 3/14/2025 | Inventor(s): Kenneth Witwer, Zach Troyer

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Category(s): Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Respiratory Diseases, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Therapeutic Modalities, Technology Classifications > Diagnostics

Dendrimer-delivered alpha-particle radiotherapy for treatment of glioblastoma and possibly of other cancers in the brain

#C17436Inventor(s): Stavroula Sofou (primary), Kannan Rangaramanujam, Rajiv NairUnmet NeedGlioblastoma accounts for 49.1 percent of all primary malignant brain tumors. Although current standard of care, which includes surgery, followed by radiotherapy, and chemotherapy, may prolong survival, the five-year survival rate for glioblastoma patients is only...

Published: 3/14/2025 | Inventor(s): Stavroula Sofou, Kannan Rangaramanujam, Rajiv Nair

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology > Glioblastoma, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Immuno-Oncology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Neutrophil Suppression as Preconditioning to Increase Efficacies and Safety of Oncolytic Bacterial Therapies

Unmet NeedHypoxia is a prominent feature of solid tumors and can function as fertile environment for oncolytic anaerobic bacteria such as Clostridium novyi-NT (C. novyi-NT) where it can induce tumor destruction in mice and patients. However, two major obstacles have limited its use, namely the host inflammatory response and the incomplete clearance...

Published: 3/14/2025 | Inventor(s): Renyuan Bai, Verena Staedtke

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Oncology > Glioblastoma, Clinical and Disease Specializations > Immuno-Oncology, Technology Classifications > Therapeutic Modalities > Targets

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