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Mitigation of Nuclear Pore defect in Neurodegeneration: ESCRT Pathway Inhibition
Value PropositionNovel Target: CHMP7, a nuclear pore protein, identified as a key driver in ALS, offers a new therapeutic approach.Disease-Modifying Method: Targets the root cause of nuclear pore complex injury and neural injury, aiming to alter disease progression.Druggable Target: CHMP7 can be inhibited using small molecule, gene, and peptide therapies.Broad...
Published: 3/14/2025
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Inventor(s):
Jeffrey Rothstein
,
Alyssa Coyne
Keywords(s):
Category(s):
Clinical and Disease Specializations > Neurology > Amyotrophic Lateral Sclerosis
,
Clinical and Disease Specializations > Neurology > Dementia
,
Clinical and Disease Specializations > Neurology > Alzheimer's Disease
,
Clinical and Disease Specializations > Neurology > Huntington's Disease
,
Clinical and Disease Specializations > Neurology > Neurodegeneration
,
Technology Classifications > Therapeutic Modalities > Targets
Discovery of Small Molecule Inhibitors of Neutral Sphingomyelinase 2 (nSMase2) for the Treatment of Neurodegenerative Diseases
Unmet NeedIn the brain, neutral sphingomyelinase 2 (nSMase2) is expressed in neurons and increased activity and expression of this enzyme has been associated with pro-inflammatory conditions observed in Alzheimer’s disease, multiple sclerosis and human immunodeficiency virus (HIV-1) patients. Inhibition of human nSMase2 may preserve neuronal function...
Published: 3/13/2025
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Inventor(s):
Barbara Slusher
,
Camilo Rojas
,
Ajit Thomas
,
Radim Nencka
,
Michal Sala
,
Hubert Hrebabecky
,
Norman Haughey
Keywords(s):
Alzheimer's Disease
,
Antagonists/Inhibitors
,
Assay
,
Clinical Diagnostics
,
CNS and Neurological Disorders
,
Disease Indication
,
In Vitro Diagnostics
,
Non-novel
,
Off-the-shelf
,
Predicted Novelty
,
Small Molecules
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Neurology
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Technology Classifications > Therapeutic Modalities > Small Molecules
,
Technology Classifications > Therapeutic Modalities
,
Clinical and Disease Specializations > Neurology > Alzheimer's Disease
Inhibition of rip kinases for treating neurodegenerative disorders
Unmet NeedNeurodegenerative disorders are a heterogeneous group that includes Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), dementia, and Huntington’s disease. These disorders result from progressive degeneration of the structure, function, and network of neurons in the central nervous...
Published: 3/13/2025
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Inventor(s):
Seulki Lee
,
Han Seok Ko
,
Ted Dawson
,
Martin Pomper
,
Donghoon Kim
,
Yumin Oh
,
Seung-Hwan Kwon
,
Yong Joo Park
Keywords(s):
Alzheimer's Disease
,
Antagonists/Inhibitors
,
CNS and Neurological Disorders
,
Disease Indication
,
Neurodegenerative Diseases
,
Parkinson's Disease
,
Small Molecules
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
Category(s):
Technology Classifications > Therapeutic Modalities > Small Molecules
,
Clinical and Disease Specializations > Neurology > Neurodegeneration
,
Clinical and Disease Specializations > Neurology > Alzheimer's Disease
,
Clinical and Disease Specializations > Neurology > Parkinson’s Disease
Methods to Treat Neurodegenerative Diseases
Unmet NeedAn estimated 930K people in the US are living with a neurodegenerative disease (Alzheimer’s and Parkinson’s are most common). However, current standard of care treatments mostly addresses symptoms of these diseases. To date no disease modifying or neuroprotective treatments are approved for Parkinson, and only 1 recently has been for Alzheimer’s...
Published: 3/14/2025
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Inventor(s):
Rana Rais
,
Barbara Slusher
,
Arindom Pal
Keywords(s):
Category(s):
Technology Classifications > Therapeutic Modalities
,
Technology Classifications > Therapeutic Modalities > Small Molecules
,
Clinical and Disease Specializations > Neurology > Alzheimer's Disease
,
Clinical and Disease Specializations > Neurology > Multiple Sclerosis
,
Clinical and Disease Specializations > Neurology > Amyotrophic Lateral Sclerosis
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Clinical and Disease Specializations > Neurology > HIV-Associated Neurocognitive Disorders
The Efficacy of Nanozyme in Neurodegenerative Diseases
Unmet NeedOxidative stress and subsequent prion-like pathology is an essential driver n the pathogenesis of neurodegenerative diseases, including Parkinson’s Disease (PD and Alzheimer’s disease (AD). Currently, only symptomatic treatments are available, and there is a great unmet need to develop a cure. Technology OverviewDisclosed herein are novel...
Published: 3/14/2025
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Inventor(s):
Xiaobo Mao
,
Shuya Li
,
Weiwei He
Keywords(s):
Category(s):
Clinical and Disease Specializations > Neurology > Alzheimer's Disease
,
Clinical and Disease Specializations > Neurology > Neurodegeneration
,
Clinical and Disease Specializations > Neurology > Parkinson's Disease
,
Clinical and Disease Specializations > Neurology > Parkinson’s Disease
,
Technology Classifications > Therapeutic Modalities > Proteins
Identification of TDP-43 Cryptic Exons as Functional Fluid Biomarkers for Alzheimer's Disease and Related Dementia
JHU C16735Unmet Need: TDP-43 (Tar DNA-binding protein 43) acts as a guardian of the transcriptome by repressing the splicing of non-conserved, unannotated cryptic exons. Loss of TDP-43 function causes neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Limbic-Predominant Age-Related TDP-43 Encephalopathy...
Published: 3/14/2025
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Inventor(s):
Philip Wong
,
Jonathan Ling
Keywords(s):
Category(s):
Technology Classifications > Therapeutic Modalities > Proteins
,
Clinical and Disease Specializations > Neurology > Alzheimer's Disease
,
Clinical and Disease Specializations > Neurology > Dementia
Digital 3D Brain MRI Arterial Territories Atlas
Unmet Need: The human cerebroarterial system is composed of a complex system of arteries that supply the brain cells with oxygen and nutrition. Cerebroarterial networks are difficult to analyze due to their composition of small and large arteries, which have a complex organization of branches and cyclic connections that varies among individuals. Analyzing...
Published: 3/14/2025
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Inventor(s):
Andreia Faria
,
Chin-Fu Liu
Keywords(s):
Category(s):
Clinical and Disease Specializations > Neurology
,
Clinical and Disease Specializations > Neurology > Alzheimer's Disease
,
Clinical and Disease Specializations > Neurology > Cerebral Aneurysm
,
Clinical and Disease Specializations > Neurology > Stroke
,
Clinical and Disease Specializations > Neurology > Cerebral Ischemia
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Copyright
,
Technology Classifications > Computers, Electronics & Software > Databases
,
Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis
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Technology Classifications > Computers, Electronics & Software > Machine Learning
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Technology Classifications > Medical Devices > Imaging
,
Technology Classifications > Research Tools > Imaging
,
Technology Classifications > Computers, Electronics & Software > Artificial Intelligence
Lucidity Mobile Application and Ecosystem
Unmet NeedAlzheimer's disease is a progressive neurodegenerative disorder of the central nervous system that leads to mental deterioration and eventually death. Currently, in the United States, there are more than 6 million people living with Alzheimer’s. Often, even with Alzheimer’s patients in severe cognitive decline, patients will experience...
Published: 3/14/2025
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Inventor(s):
Kishore Kuchibhotla
,
Aaron Wang
Keywords(s):
Category(s):
Clinical and Disease Specializations > Neurology > Alzheimer's Disease
,
Technology Classifications > Computers, Electronics & Software > Machine Learning
,
Technology Classifications > Computers, Electronics & Software > Sensors
,
Technology Classifications > Computers, Electronics & Software
Stimulation of Dendrite Growth and Spine Formation by Norrin and LGR6: A Target for Therapy in CNS Injury and Degeneration
Unmet NeedAstroglial dysfunction is associated with the development of numerous central nervous system (CNS) diseases, including amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and Huntington’s disease (HD). Astroglia are the homeostatic cells of the central nervous system and play key roles in the development and support of neuronal...
Published: 3/14/2025
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Inventor(s):
Sean Miller
,
Jeffrey Rothstein
Keywords(s):
Alzheimer's Disease
,
Amyotrophic Lateral Sclerosis
,
Biologics
,
CNS and Neurological Disorders
,
Dementia
,
Disease Indication
,
Huntington's Disease
,
Parkinson's Disease
,
Protein
,
Target
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
Category(s):
Clinical and Disease Specializations > Neurology > Neurodegeneration
,
Clinical and Disease Specializations > Neurology > Amyotrophic Lateral Sclerosis
,
Clinical and Disease Specializations > Neurology > Dementia
,
Technology Classifications > Therapeutic Modalities > Proteins
,
Clinical and Disease Specializations > Neurology > Alzheimer's Disease
,
Technology Classifications > Therapeutic Modalities > Targets
,
Clinical and Disease Specializations > Neurology > Huntington's Disease
,
Clinical and Disease Specializations > Neurology > Parkinson’s Disease
Conditional Tau Mouse Lines that Faithfully Recapitulate Alzheimer’s Disease-like Pathologies
Value Proposition: Effective therapy for Alzheimer’s disease (AD), the most common form of dementia and a devastating illness for the elderly, remains a great unmet need. For translational research and preclinical drug development, animal models that faithfully mimic the cardinal pathological features of AD are critical. A major limitation of current...
Published: 3/13/2025
|
Inventor(s):
Philip Wong
,
Donald Price
,
Tong Li
Keywords(s):
Alzheimer's Disease
,
Basic Research Biomarker
,
Cell Lines
,
CNS and Neurological Disorders
,
Discovery/Research Tools
,
Disease Indication
,
In Vitro Research Tool
,
In Vivo Research Tool
,
Mouse Cell Lines
,
Mouse Model
,
Neurodegeneration
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Geriatrics
,
Clinical and Disease Specializations > Neurology > Alzheimer's Disease
,
Clinical and Disease Specializations > Neurology > Neurodegeneration
,
Clinical and Disease Specializations > Rare Diseases
,
Technology Classifications > Research Tools > Animal Models
,
Technology Classifications > Research Tools > Cell Lines
,
Clinical and Disease Specializations > Neurology
,
Technology Classifications > Research Tools
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