Search Results - dario+vignali

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Identification of LAG3 as the α-synuclein Neuronal Transmission Receptor

Unmet Need: Parkinson’s disease (PD) is the second most common neurodegenerative disorder and leads to slowness of movement, tremor, rigidity, and, in the later stages of PD, cognitive impairment. Pathologically, PD is characterized by the accumulation of α-synuclein in Lewy bodies and neurites. Emerging evidence indicates that the pathogenesis of Parkinson's...

Published: 3/13/2025 | Inventor(s): Ted Dawson, Valina Dawson, Han Seok Ko, Xiaobo Mao, Dario Vignali, Creg Workman

Keywords(s): Biomarker, CNS and Neurological Disorders, Disease Indication, Mechanism-of-action Biomarker, Parkinson's Disease, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities

Mouse Anti-LAG3 Monoclonal Antibody (4-10-C9)

C11691: Mouse LAG-3 Monoclonal AntibodyNovelty: A mouse monoclonal antibody (mAb) against LAG-3 (Lymphocyte Activation Gene 3).Value Proposition: LAG-3 is expressed on the cell surface of activated T-cells and is known to be an important global regulatory molecule that controls many aspects of T-cell proliferation and homeostasis. This invention is...

Published: 3/13/2025 | Inventor(s): Dario Vignali, Charles Drake

Keywords(s): Antibodies, Basic Research Biomarker, Discovery/Research Tools, Monoclonal Antibodies, Proteomics/Immunoassays, Proteomics/Immunoassays Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools

Johns Hopkins University PROTEIN-DB2 Database System

C04853: Johns Hopkins University PROTEIN-DB2 Database SystemNovelty: The current invention is a relational database for proteomic experiments.Value Proposition: Proteomic data collection follows complex workflow, ranging from gel electrophoresis to mass spectrometry to liquid chromatography or a combination thereof. In addition, amplification of low-abundance...

Published: 3/13/2025 | Inventor(s): Raimond Winslow, Stephen Granite, Chunguang Yang, Ali Ali, Donita Robinson

Keywords(s): Computer and Network Systems, Computer Software, Computing; Calculating; Counting, Data Processing Systems or Methods, Specifically Adapted fo~, Data Processing Systems or Methods, Specifically Adapted for, Physics

Category(s): Technology Classifications > Computers, Electronics & Software > Financial Tech, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Computers, Electronics & Software > Databases