Search Results - rachel+an

12 Results

Sort By:

Dynamical Systems Modeling of the Epileptic Brain for Seizure Onset Localization

Unmet NeedEvery year, around 5 million people are diagnosed with epilepsy globally. About 30% of the global epileptic population have medically refractory epilepsy (MRE) with seizures that cannot be controlled with medication. MRE patients have two treatment options: surgical resection of or electrical stimulation of the seizure onset zone (SOZ). Both...

Published: 6/28/2024 | Inventor(s): Sridevi Sarma, Golnoosh Kamali, Rachel Smith, Joon Kang

Keywords(s):

Category(s):

OpenCRAVAT, An Open Source Collaborative Platform for the Annotation of Human Genetic Variation

Unmet NeedGene variants are complex to interpret, involving different published methods, databases, algorithms for ranking genes and different prediction tools. Decision support frameworks were created to integrate these various resources into one environment. However, current frameworks are limited by a closed proprietary architecture, limiting its...

Published: 6/28/2024 | Inventor(s): Rachel Karchin, Kymberleigh Pagel, Michael Ryan, Rick Kim, Kyle Moad

Keywords(s): Computer and Network Systems, Computer Software, Database Management Software

Category(s): Technology Classifications > Computers, Electronics & Software > Databases, Technology Classifications > Computers, Electronics & Software > Algorithms, Clinical and Disease Specializations > Genetic Diseases, Clinical and Disease Specializations > Oncology

Local Sustained-release Nanocrystal Formulations to Treat and Prevent GI Fibrosis

Unmet Need: Gastrointestinal (GI) fibrosis, the accumulation of scar tissue in the intestinal wall as a complication in common GI autoimmune diseases such as ulcerative colitis (UC) and Crohn’s disease (CD), leads to intestinal strictures, abdominal pain, and reduced intestinal motility. Current pharmacological and surgical treatment methods have significant...

Published: 6/28/2024 | Inventor(s): Laura Ensign-Hodges, Florin Selaru, Min Kyung Joo, Rachel Shapiro, Ling Li

Keywords(s):

Category(s): Clinical and Disease Specializations > Gastroenterology

Cancer CellNet

Cancer CellNet Case ID: C15632 Disclosure Date: 9/6/2019 Unmet Need Cancer is a formidable healthcare challenge and, in the case of solid tumors, tumor metastases are the primary cause of all mortality. Patients presenting with metastatic tumors originating from an unknown primary malignancy represent a significant clinical...

Published: 6/28/2024 | Inventor(s): Patrick Cahan, Da Peng, Rachel Gleyzer

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Healthcare IT

ACL Reconstruction Surgery Tool

Unmet NeedFor successful anterior cruciate ligament (ACL) reconstruction, accurate placement of the femoral tunnel is crucial for successful surgery. The torn ligament has to be removed so that the surgeon can see the original ligament attachment sites on the bone, known as the footprints. At these footprints, tunnels are then drilled into the femur...

Published: 6/27/2024 | Inventor(s): Mohit Singhala, Matthew Lerner, Polly Ma, Andrew Jann, Rachel An, Bashir Zikria

Keywords(s): ACL, Disease Indication, Interventional and Surgical Systems, Surgical Instruments, Surgical Tubing, Traumatic Injury

Category(s): Technology Classifications > Medical Devices > Surgical, Clinical and Disease Specializations > Surgery

VEST (Variant Effect Scoring Tool)

VEST (Variant Effect Scoring Tool) is a machine learning method that predicts the pathogenicity of missense and insertion/deletion variants observed through genome sequencing, allowing them to be prioritized in subsequent functional studies.https://karchinlab.org/apps/appVest.html

Published: 6/27/2024 | Inventor(s): Rachel Karchin, Hannah Carter, Christopher Douville

Keywords(s): Computing; Calculating; Counting, Electrical Digital Data Processing, Physics

Category(s): Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Computers, Electronics & Software

SNVBox – UPDATE

Unmet Need In the new “post-genome” era of personalized medicine, many variants critical to disease susceptibilities and drug sensitivities will be identified and increased numbers of people will undergo genetic testing. The Karchin group is developing algorithms and tools to facilitate this process. These models are being applied to cancer genomics,...

Published: 6/27/2024 | Inventor(s): Rachel Karchin, Michael Ryan, Mark Diekhans, Hannah Carter, Christopher Douville, Rick Kim

Keywords(s): Computer and Network Systems, Computer Software, Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computer Systems Utilizing Knowledge Based Models, Computing; Calculating; Counting, Data Processing Systems or Methods, Specifically Adapted fo~, Data Processing Systems or Methods, Specifically Adapted for, Electrical Digital Data Processing, Physics

Category(s): Technology Classifications > Computers, Electronics & Software, Technology Classifications > Computers, Electronics & Software > Financial Tech, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Computers, Electronics & Software > Algorithms

A Bayesian Inference Model to Predict Phenotype from Personal Variation

C12508: Bayesian Inference Model to Predict Phenotype from Personal VariationNovelty: An inference model that predicts the probability of medically relevant phenotypes from an individuals genomic information.Value Proposition: Genetic testing is increasingly used as a diagnosis, linking genomic data to specific phenotypic characteristics; however, due...

Published: 6/27/2024 | Inventor(s): Yun-Ching Chen, Rachel Karchin

Keywords(s): Computer Systems Based on Mathematical Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Electrical Digital Data Processing, Physics

Category(s): Technology Classifications > Computers, Electronics & Software, Technology Classifications > Computers, Electronics & Software > Healthcare IT

Mutation Position Imaging Toolbox (muPIT) Interactive: Webserver for mapping variant positions to annotated, interactive 3D structures

C12199: Mutation Position Imaging Toolbox (muPIT) InteractiveNovelty: The current invention is a browser-based application for single nucleotide variants and mutations, designed to map genomic positions onto 3D protein structures.Value Proposition: The vast amount of available sequencing data is evidence that the limiting factor of research is shifting...

Published: 6/27/2024 | Inventor(s): Rick Kim, Mark Diekhans, Michael Ryan, Rachel Karchin, Dewey Kim

Keywords(s): Computational Modeling Tool, Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Discovery/Research Tools, Electrical Digital Data Processing, In Silico Research Tool, Nanoscale Modeling, Physics

Category(s): Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Research Tools

Novel Human Metastatic Breast Cancer Cell Line (RBC3)

C11928: Novel Human Metastatic Breast Cancer Cell Line (RBC3) Value Proposition: Johns Hopkins researchers developed a human breast cancer cell line (RBC3) to study spinal metastasis. Specifically, the cell line was isolated from a spinal metastatic lesion, and was tagged with GFP and luciferase. When RBC3 is injected into the left ventricle of athymic...

Published: 6/27/2024 | Inventor(s): Daniel Sciubba, Mari Groves, Colette Aprhys, Rachel Sarabia-Estrada, Patricia Zadnik

Keywords(s): Breast Cancer, Cancer Cells, Cancers, Cell Lines, Cell Model, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

1 2