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Delayed Lagging Strand Synthesis Promotes Male Fertility during Aging

Inhibition-based Method for Stem Cells Induction from Non-Stem Cells Value Proposition:· Induces stem cells from non-stem cells through modification of gene expression or function. · Relies on influencing a single DNA replication component rather than multiple molecular factors.· Successfully rescues both male and female fertility in...

Published: 3/14/2025 | Inventor(s): Xin Chen, Brendon Davis, Rajesh Ranjan

Keywords(s):

Category(s): Clinical and Disease Specializations > Reproductive Health > Fertility, Clinical and Disease Specializations > Wound Healing

C13222 - A Novel Method to Reduce H3T3 Phosphorylation in Rapidly Dividing Cells

C13222UNMET NEEDCancer is incredibly difficult to treat, due to the confluence of factors that cause and perpetuate the disease and the difficulty of targeting cancer cells without affecting normal cells. As such, the academic and industry space is perpetually engaged in researching new targets and pharmacological strategies. For the past few decades,...

Published: 3/13/2025 | Inventor(s): Jing Xie, Xin Chen

Keywords(s): Cancers, Disease Indication, Therapeutic Method, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Chemical Control of Trk Signaling in Mice

C04844: Chemical Control of Trk Signaling in Mice Technical Details: Neurotrophins are a family of molecules that encourage survival of nervous tissue by secreting factors in a neuron's target field, and act by prohibiting the neuron from apoptosis. The neurotrophin family include nerve growth factors nerve growth factor (NGF), Brain-derived...

Published: 3/13/2025 | Inventor(s): David Ginty, Xi Chen

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Growth Factors, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools