Search Results - clinical+and+disease+specializations+%3e+neurology+%3e+motor+neuron+diseases

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Method to Inhibit Toxic Pathways Activated in Genetic ALS/FTD

Value PropositionTreatment readily acts via subcutaneous injection and crosses the blood-brain barrier without extra formulation or drug delivery mechanism.Treatment significantly reduces pathological and behavioral phenotypes from toxic proteins coded by genetic defects in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), which...

Published: 3/14/2025 | Inventor(s): Shuying Sun, Zhe Zhang

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Amyotrophic Lateral Sclerosis, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Neurology > Motor Neuron Diseases, Clinical and Disease Specializations > Neurology > Dementia, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics > Biomarkers

3D Shell MEAs for Electrically Active Organoids

Value Proposition· 3D shell MEAs is a novel platform for encapsulation, electrical stimulation, and recording of organoids· Electrophysiological measurements of electrically active 3D organoids. · Relevant to brain development, neurological disorders, drug screening; neuromorphic computing and brain-machine interfaces; and organoid...

Published: 3/14/2025 | Inventor(s): David Gracias, Lena Smirnova, Qi Huang

Keywords(s):

Category(s): Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Motor Neuron Diseases, Clinical and Disease Specializations > Neurology > Multiple Sclerosis, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Neurology > Neuropathy, Technology Classifications, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Research Stem Cells

NG2-cDTa mice

C11678: Transgenic Mouse Line with Inducible Diphtheria Toxin GeneNovelty: A novel line of transgenic mice expressing stable inducible diphtheria toxin gene under the control of an NG-2 promoter. This mouse line can be used in neuroscience studies to induce a model state of chronic demyelination.Value Proposition: Neuronal cell studies are an important...

Published: 3/13/2025 | Inventor(s): Shin Kang, Dwight Bergles

Keywords(s): Amyotrophic Lateral Sclerosis, Amyotrophic Laterial Sclerosis (ALS), Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock In Mouse Model, Motor Neuron Diseases, Mouse Model, Mouse Model Xenograft, Neurodegeneration