Search Results - dwight+bergles

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Inner Ear-Specific Cre Mouse Model for Targeted Gene Deletion and Hearing Loss Research

JHU Ref #: C15757Value Proposition· Inner ear specificity: When bred with a mouse with a floxed gene of interest (GOI), the offspring will not express the GOI in the inner ear. · Applicable in multiple hearing models: Researchers can study effects of a GOI in the inner ear in both deaf and hearing mice.· Improved mouse line stability:...

Published: 4/24/2026 | Inventor(s): Dwight Bergles, Travis Babola

Keywords(s):

Category(s): Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Ear, Nose & Throat > Hearing Disorders, Technology Classifications > Research Tools

Transgenic Mouse Line with Inducible Diphtheria Toxin Gene

Novelty: A novel line of transgenic mice expressing stable inducible diphtheria toxin gene under the control of an NG-2 promoter. This mouse line can be used in neuroscience studies to induce a model state of chronic demyelination. Value Proposition: Neuronal cell studies are an important tool in deciphering the pathophysiology of disorders...

Published: 4/23/2026 | Inventor(s): Shin Kang, Dwight Bergles

Keywords(s): Amyotrophic Lateral Sclerosis, Amyotrophic Laterial Sclerosis (ALS), Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock In Mouse Model, Motor Neuron Diseases, Mouse Model, Mouse Model Xenograft, Neurodegeneration

Transgenic Mouse Line for In Vivo Calcium Ion Monitoring

Novelty: Unique transgenic mouse model comprising genetically encoded calcium indicator, GCaMP3, to monitor calcium signaling in vivo. Value Proposition: Commonly used calcium indicator dyes lack specificity and may produce error in measuring intracellular calcium. This invention is a transgenic mouse line with the genetically encoded calcium...

Published: 4/23/2026 | Inventor(s): Amit Agarwal, Dwight Bergles

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

PDGF Receptor Transgenic Mouse Line with Inducible Cre Recombinase

Novelty: Transgenic mouse line containing inducible Cre recombinase expressed under the control of platelet derived growth factor alpha receptor (PDGF\R) promoter. This PDGFR-CreER mouse model is a useful resource for studying cell specific genetic regulation of oligodendrocytes in vivo. Value Proposition: Oligodendrocytes and pericytes in...

Published: 4/23/2026 | Inventor(s): Shin Kang, Dwight Bergles

Keywords(s): Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock In Mouse Model, Mouse Model, Mouse Model Xenograft

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology

NG2-lck-EGFP Transgenic Mouse Line

Novelty: Transgenic mouse line expressing the eGFP reporter that is controlled by an NG2 promoter. This mouse model is a useful resource for in vivo as well as in vitro study of neuronal development and function. Value Proposition: Neuroglial cells like pericytes and oligodendrocytes express NG-2 proteoglycans in progenitor cells but the gene...

Published: 4/23/2026 | Inventor(s): Shin Kang, Dwight Bergles

Keywords(s): Discovery/Research Tools, In Vivo Research Tool, Mouse Model

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Diagnostics, Technology Classifications > Research Tools