Search Results - clinical+and+disease+specializations+%3e+ophthalmology

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Augmented or Virtual Reality Based Evaluation of Visual Field

Sensitive visual field assessment using augmented realityJHU Ref #: C17601Unmet NeedWhile visual field measurement is key in diagnosing and monitoring eye and systemic diseases in patients (American Academy of Ophthalmology, 2022), current practices are either quick but imprecise (confrontation visual field tests that rely on the doctor’s hand gestures...

Published: 3/14/2025 | Inventor(s): Ali Saber Tehrani, Arash Saber Tehrani

Keywords(s):

Category(s): Clinical and Disease Specializations > Ophthalmology, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Machine Learning

Novel Bioreducible Polymer for Nucleic Acid Delivery to Eyes and Beyond

Unmet NeedInherited retinal diseases (IRDs) are a group of disorders with genetic and clinical heterogeneity and are the leading cause of vision loss. [1, 20] ] Collectively, IRDs have an estimated incidence of 1:2000. [1] Gene therapies targeting IRD, including FDA approved Luxturna, are injected directly into the retina to correct the underlying genetic...

Published: 3/14/2025 | Inventor(s): Jung Soo Suk, Gijung Kwak, Kai Zhang

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Ophthalmology

A Natural Anti-inflammatory Treatment to Reduce Corneal Scarring and Dry Eye

Unmet Need:According to the WHO, approximately 4.9 million people globally are affected by bacteria that leads to corneal scarring of the eye (WHO). Additionally, in the United States alone 4.88 million people age 50 and older suffer from dry eye, which may lead to scarring of the cornea (Healthline). The cornea serves as a window to the eye, and transparency...

Published: 3/14/2025 | Inventor(s): Jennifer Elisseeff, Liam Chung, Xiaokun Wang

Keywords(s):

Category(s): Clinical and Disease Specializations > Ophthalmology, Clinical and Disease Specializations > Ophthalmology > Dry Eye Syndrome, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Medical Devices > Regenerative Medicine

Method to Measure Mechanical Strain in the Optic Nerve Head of Glaucoma Patients

Value Proposition: Non-invasive measurement of glaucoma progression and response to medicationApplicable for use on existing optical coherence tomography (OCT) imaging dataQuantifiable and dynamic biomarker of intraocular pressure-related changes to the eyePatient-specific approach to assess glaucoma risk and progressionTechnology Description: Researchers...

Published: 3/14/2025 | Inventor(s): Thao Nguyen, Harry Quigley, Cameron Czerpak, Vanessa Hannay, Dan Midgett

Keywords(s):

Category(s): Clinical and Disease Specializations > Ophthalmology, Clinical and Disease Specializations > Ophthalmology > Glaucoma, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > In Vivo Diagnostics

Automated Surgical Learning and Debriefing Platform

Unmet NeedA cataract is a condition denoted by the blurring of the lens of the eye that accounts for 51% of blindness and 33% of visual impairments worldwide (see WHO). The number of people in the U.S. with cataracts is expected to double from 24.4 million in 2010 to a projected 50 million in 2050 (see NIH). Surgery is the only corrective treatment...

Published: 3/14/2025 | Inventor(s): Shameema Sikder, Satyanarayana Vedula, Gregory Hager, Tae Soo Kim, Chien-Ming Huang, Kristen Park, Anand Malpani, Bohua Wan

Keywords(s):

Category(s): Clinical and Disease Specializations > Ophthalmology, Clinical and Disease Specializations > Surgery, Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Medical Devices > Surgery, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Research Tools > Surgical

Alpha 2 Collagen VIII (Col8a2) Q455K Knock-in Mouse Model of Fuchs Endothelial Corneal Dystrophy

Unmet Need:Fuchs’ endothelial corneal dystrophy (FECD) is a genetic disease affecting the cornea and is estimated to affect 7% of the adult population (see Aiello et al. 2022). The first genetic defect shown to cause FECD was a point mutation in the alpha 2 collagen 8 gene (Col8a2). The disease results in a buildup of fluid in the cornea and causes...

Published: 3/13/2025 | Inventor(s): Albert Jun

Keywords(s): Basic Research Biomarker, Cell Lines, Corneal Dystrophy, Discovery/Research Tools, Disease Indication, Eye Disorders, Fuchs' Endothelial Corneal Dystrophy, Fuchs Endothelial Corneal Dystrophy (FECD), In Vitro Research Tool, Mouse Cell Lines

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Ophthalmology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Ophthalmology > Corneal Dystrophy, Clinical and Disease Specializations > Ophthalmology > Fuchs' Endothelial Corneal Dystrophy

Low Cost Manual Cataract Fragmentation Device for Improved Access and Outcomes

Unmet Need / Invention Novelty: 17 M people are blind and 83.5 M have moderate-to-severe visual impairment due to cataracts, which disproportionately affect individuals in low- and middle-income countries (LMICs). The current gold standard, phacoemulsification, requires significant initial capital expense and equipment and recurring costs for consumables...

Published: 3/14/2025 | Inventor(s): Kunal Parikh, Namratha Potharaj, Nicholas Calafat, Daniel Myers, Brittany Reed, Krithik Srithar, Samuel Yiu, George Coles, Kapil Mishra, Nakul Shekhawat, Joshua De Souza

Keywords(s):

Category(s): Clinical and Disease Specializations > Ophthalmology, Technology Classifications > Medical Devices

Methods and Compositions for Achieving Sustained Intraocular Drug Delivery via Melanin Binding

Unmet Need / Invention Novelty: Intravitreal injection is the gold standard for achieving drug delivery to the posterior segment of the eye. However, achieving effective delivery is challenging and the injections need to be performed frequently which hinders patient compliance. There therefore exists an unmet need to develop a formulation for intraocular...

Published: 3/14/2025 | Inventor(s): Laura Ensign-Hodges, Justin Hanes, Yoo Chun Kim, Tung Heng Hsueh

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Ophthalmology

Compositions and methods for controlled release suprachoroidal drug delivery

Unmet Need / Invention Novelty: Traditional routes of administrating drugs to the eye are limited by lack of efficiency, frequent side effects, and poor patient tolerance of repeated injections into the eye. Injections into the suprachoroidal space (SCS) is an attractive strategy to overcome these limitations and to provide for targeted delivery of...

Published: 3/14/2025 | Inventor(s): Laura Ensign-Hodges, Peter Campochiaro, Justin Hanes, Yoo Chun Kim, Jikui Shen, Jie Fu

Keywords(s): Disease Indication, Drug Delivery Mechanism, Drug Delivery Vehicle, Eye Disorders, Hydrogel, Local Ocular, Microspheres, Polymers, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations > Ophthalmology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Compensating for Polarization Changes Introduced by Components with Retardation in Polarization Sensitive Retinal Scanning Systems

Unmet NeedThe most sensitive part of the human retina, the fovea, changes the polarization state of light when scanned with a low-power polarized beam of light. This produces a particular pattern which can be used for eye tracking or monitoring central fixation. The latter is useful in diagnosing strabismus (cross-sightedness) and amblyopia (“lazy eye”),...

Published: 3/14/2025 | Inventor(s): Boris Gramatikov, David Guyton

Keywords(s): Industrial Equipment, Industrial Manufacturing, Machine Tools, Manufacturing Method

Category(s): Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Engineering Tech > Industrial Manufacturing, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Ophthalmology

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