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Unmet NeedImpairment of neuronal function in adults is challenging to treat. No pharmaceutical interventions have shown promise in restoring cognitive and motor function after acute neurologic injury, as is the case in recovery following transient ischemic attack or stroke. Treatment of neurologic, cognitive, and motor impairment in the mature brain...

Published: 7/5/2024 | Inventor(s): Gul Dolen, John Krakauer, Romain Nardou, Steven Zeiler, Junia de Deus

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Repurposed Drugs, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Stroke, Clinical and Disease Specializations > Neurology > Cerebral Ischemia

The Development of a Mini-scale Euglobulin Clot Lysis Assay

Unmet Need· A large proportion of patients with bleeding disorders fail to be diagnosed, and are classified as having bleeding of unknown cause due to a lack of sensitive assays for detecting abnormalities in fibrinolytic factors (Mehic et al. 2021). In addition, patients with young-onset or unprovoked venous thromboembolism, as well as those...

Published: 7/5/2024 | Inventor(s): Neil Goldenberg, Vera Ignjatovic, Steven Bruzek

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Diagnostics > In Vitro Diagnostics, Clinical and Disease Specializations > Cardiovascular, Clinical and Disease Specializations > Fibrosis, Clinical and Disease Specializations > Hematology, Clinical and Disease Specializations > Pediatrics

Monoclonal Antibodies Specific to AGK, for Research Purposes

Unmet Need: Acylglycerol kinase, AGK, is a protein in the TIMM22 translocon and is postulated to be important in cardiolipin biogenesis. Mutations in the gene encoding for AGK also can result in human disease, making the study of the protein important in understanding disease pathogenesis. Currently there are no validated human AGK specific antibodies,...

Published: 7/5/2024 | Inventor(s): Steven Claypool

Keywords(s):

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Research Antibodies, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Metabolic Diseases

Monoclonal Antibody Specific to Human ANT1, for Research Purposes

Unmet Need: ANT1, also known as solute carrier family 25 member 4 (SLC25A4), is a protein important for mitochondrial energy production and is relevant in the research of human mitochondrial diseases. Mutations in the gene encoding for ANT1 also can result in human disease, making the study of the protein important in understanding disease pathogenesis....

Published: 7/5/2024 | Inventor(s): Steven Claypool

Keywords(s):

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Research Antibodies, Technology Classifications > Research Tools > Antibodies, Clinical and Disease Specializations > Metabolic Diseases

AI-based Disease Detection from Raw SPECT and PET Data without Image Reconstruction

Inventor(s): Yong Du, Kevin Leung, Martin Pomper, Steven RoweUnmet NeedParkinson’s disease (PD) is the second most common neurodegenerative disorder, with approximately 60,000 Americans diagnosed with it each year. It is a progressive nervous system disorder that affects movement, from small tremors to a loss of automatic movements. One of the tools...

Published: 7/5/2024 | Inventor(s): Yong Du, Kevin Leung, Martin Pomper, Steven Rowe

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Clinical and Disease Specializations > Neurology > Parkinson’s Disease, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Diagnostics

AI Based Medical Image Generation

Unmet NeedAdvances in medical imaging has radically changed the practice of medicine in the last few decades. Recently, machine learning techniques have been shown to produce higher fidelity images in various modalities and to aid in diagnostics (Lundervold & Lundervold, 2019). Machine learning imaging research require large datasets to be trained...

Published: 7/5/2024 | Inventor(s): Yong Du, Kevin Leung, Martin Pomper, Steven Rowe, Wenyi Shao

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Databases, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Medical Devices > Imaging

Multi-spectral High Speed Imaging of AM Builds for Positional Thermal Sensing

Unmet Need: Metal 3D printing, and in particular selective laser melting (SLM), is an emerging manufacturing technology which enables realization of new, complex parts incorporating a variety of composite materials. Despite SLM’s unique and remarkable ability to produce metal parts with features and mechanical properties not achievable using conventional...

Published: 7/5/2024 | Inventor(s): Mark Foster, Milad Alemohammad, Nathan Drenkow, Brendan Croom, Ryan Carter, Robert Mueller, Steven Storck

Keywords(s):

Category(s): Technology Classifications > Industrial Tech, Technology Classifications > Industrial Tech > Industrial Manufacturing

Cell Impregnated Nanofiber Stent Sleeve ("CINSS") for Intravascular Growth Factor Production

Invention novelty:Stem cells are harnessed to create a stent-based “paracrine factor factory” using a novel biodegradable nanofiber sleeve which protects the cells from washout and immune attack, and provides a sheltered in vivo on-stent milieu for the cells to continuously produce and deliver healing growth factors and exosomes to injured tissue.Value...

Published: 7/4/2024 | Inventor(s): Chao-Wei Hwang, Zhiyong Xia, Virginia Bogdan, Jeffrey Brinker, Gary Gerstenblith, Peter Johnston, Steven Schulman, Gordon Tomaselli, Robert Weiss

Keywords(s): Drug Delivery Vehicle, Hydrogel, Implanted Device, Implants, Stent, Therapeutic Devices, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities

Polymer of Prodrug Methods for Sustained Release of Antivirals for Treatment or Prevention of HIV

Unmet Need:Human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS) are amongst the most serious and challenging health problems in the world. There are nearly 37 million people worldwide living with HIV/AIDS and approximately 1 million AIDS-related deaths have occurred in 2017 alone - about 5,000 new infections per...

Published: 7/5/2024 | Inventor(s): Caren Freel Meyers, Steven Rannard, Andrew Owen, Kartik Temburnikar, Lauren Coco, Stephanie Henriquez, Faye Hern, Chung Liu, Anika Shakil, Megan Neary

Keywords(s): Disease Indication, HIV, Infectious Diseases, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Spatial-spectral filters for multi-material decomposition in computed tomography

Unmet NeedMore than 80 million CT scans are conducted every year in the US to detect and monitor a variety of diseases such as cancer, heart disease, and bone disorders. CT scans make use of computer-processed combinations of X-ray measurements to produce images of the patient’s body. The methods for this processing are constantly changing due to advancements...

Published: 7/4/2024 | Inventor(s): Joseph Stayman, Steven Tilley

Keywords(s): Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, X-ray Computed Tomography (CT)

Category(s): Technology Classifications > Medical Devices > Imaging

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