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Detection of Cancer in Body Fluids Using Cell Enrichment and Flow Cytometry

Unmet NeedEarly detection of cancer is critical for diagnosis, informing treatment, and improving prognostic outcomes. Solid biopsies can be difficult to obtain and provide limited information on tumor composition. In recent years, liquid biopsies have allowed for non-invasive testing of circulating tumor-derived components, such as tumor cells or nucleic...

Published: 3/14/2025 | Inventor(s): Jonathan Dudley, Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos

Keywords(s):

Category(s): Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Precision Medicine Tools, Technology Classifications > Diagnostics > Companion Diagnostics, Clinical and Disease Specializations > Oncology

Segmenting retinal OCT images with inter-B-scan and longitudinal information

Unmet NeedA recent study by the National Multiple Sclerosis Society found that nearly one million people are living with multiple sclerosis (MS) in the United States, making it the most common immune-mediated inflammatory demyelinating disease of the nervous system. Due to few disease-specific characteristic symptoms and the varied pace of disease progression...

Published: 3/14/2025 | Inventor(s): Jerry Prince, Yufan He, Aaron Carass

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology > Multiple Sclerosis, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Diagnostics > Companion Diagnostics, Technology Classifications > Medical Devices > Imaging

Multiplex Mass Spectrometry Assay on a Pentaflouropropyl (PFPP) Stationary Phase

Dried blood spot (DBS) tests are an important diagnostic tool used for newborns. Unfortunately DBS has a variety limitations. According to the CDC, approximately four million DBS tests are required for infants are born in the United States each year. Conventional newborn screening with DBS begins with the addition of capillary blood droplets from a...

Published: 3/14/2025 | Inventor(s): David Graham, Aurelie Roux, Robert Harlan

Keywords(s):

Category(s): Clinical and Disease Specializations > Hematology, Technology Classifications > Diagnostics > Companion Diagnostics, Technology Classifications > Research Tools > Blood & Tissue Samples, Technology Classifications > Diagnostics

Predictors of QTVI, A Marker of Sudden Cardiac Death: Sleep Heart Health Study

Unmet NeedSudden cardiac death is the leading cause of mortality in patients with chronic heart failure. However, there isn’t a standard method of assessing risk for SCDs, which is necessary for early prevention (e.g. through the implantation of a cardioverter defibrillator). Technology OverviewThe QT Variability index, measured through an electrocardiogram,...

Published: 3/14/2025 | Inventor(s): Naresh Punjabi, Raghav Ramachandran, Hannah Cowley

Keywords(s):

Category(s): Clinical and Disease Specializations > Cardiovascular > Heart Failure, Technology Classifications > Diagnostics > Companion Diagnostics

Mini-cancers Utilization as Decision Tools for Personalized Cancer Drug Regimens

The present invention includes methods for identifying chemotherapy treatments specifically suited for each cancer patient. The methods include obtaining a biopsy from the cancer patient; establishing a cancer culture from the biopsy; mixing the cancer culture with a matrix forming mini cancers. The mini cancers are then used to screen chemotherapy...

Published: 3/13/2025 | Inventor(s): Florin Selaru, Ling Li

Keywords(s): Assay, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Research Instrument, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Companion Diagnostics, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

Production, Purification, Reconstitution and Functional Characterization of a Human Zinc Transporter ZnT8

Unmet NeedThe escalating type-2 diabetes (T2D) epidemic is a major global health concern. Genes affecting risk for T2D include the zinc transporter gene ZnT8. There exist a need for better production, purification, reconstitution and functional characterization of the human ZnT8, and improved methods for detection and treatment of T2D.Technology OverviewThe...

Published: 3/13/2025 | Inventor(s): Dax Fu

Keywords(s): Discovery/Research Tools, Proteomics/Immunoassays, Research Reagent

Category(s): Technology Classifications > Diagnostics > Companion Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools