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Flux Qubit based on Spin-triplet Superconductors

Value Proposition· Improved consistency of magnetic field generation · Easier fabrication · Reduced energy costs· Enhanced computing capabilitiesUnmet Need· As the computational demands of society progress, so does the need for inventive approaches to increasing computing power. The foundation of quantum computing is the...

Published: 3/14/2025 | Inventor(s): Chia-Ling Chien, Xiaoying Xu, Yufan Li

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Segmenting retinal OCT images with inter-B-scan and longitudinal information

Unmet NeedA recent study by the National Multiple Sclerosis Society found that nearly one million people are living with multiple sclerosis (MS) in the United States, making it the most common immune-mediated inflammatory demyelinating disease of the nervous system. Due to few disease-specific characteristic symptoms and the varied pace of disease progression...

Published: 3/14/2025 | Inventor(s): Jerry Prince, Yufan He, Aaron Carass

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Category(s): Clinical and Disease Specializations > Neurology > Multiple Sclerosis, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Diagnostics > Companion Diagnostics, Technology Classifications > Medical Devices > Imaging

Identification of Novel Coumestan Derivatives as Pks13 Inhibitors against Mycobacterium Tuberculosis

Unmet NeedTuberculosis (TB) is an infectious disease caused by the bacteria Mycobacterium tuberculosis (Mtb), which typically impacts the lungs. In 2016, there were 10.4 million new cases of TB and 1.7 million deaths worldwide, with approximately one-fourth of the world’s population infected. As a result, TB is one of the leading infectious disease...

Published: 3/14/2025 | Inventor(s): William Bishai, Shichun Lun, Li-Fang Yu, Shu-Huan Wang, Fan Yang, Jie Tang, Hendra Gunosewoyo, Ashlee Earl, Abigail Manson, Wei Zhang

Keywords(s): Antagonists/Inhibitors, Disease Indication, Infectious Diseases, Myobacterium Tuberculosis, Natural compounds, Non-novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Tuberculosis (TB)

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB)

Spontaneous Half-quantum Flux Qubit Constructed with Novel Superconducting Materials

Unmet NeedThere is a need for improved quantum computing technology outside the standard superconducting loops where are currently in the process of being developed by a number of major corporations and research institutions. Superconducting loops require extensive cryogenic isolation and have comparably low longevity and logic success rates. In comparison...

Published: 3/14/2025 | Inventor(s): Chia-Ling Chien, Yufan Li, Xiaoying Xu

Keywords(s): Computer and Network Systems, Computer Hardware, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Physics

Category(s): Technology Classifications > Computers, Electronics & Software

Neuritin Impact T Cell Tolerance Induction and Maintenance and is a Target for Tumor Immunotherapy

Unmet NeedCancer immunotherapy is a therapeutic approach that has revolutionized advanced cancer treatment. In particular, the use of therapeutic blocking antibodies to cytotoxic T-lymphocyte antigen 4 (CTLA4) and programmed cell death protein (PD-1) has achieved routine clinical use in numerous indications. Despite these promising results, monotherapy...

Published: 3/14/2025 | Inventor(s): Drew Pardoll, Hong Yu, Joseph Barbi, Fan Pan, Charles Drake

Keywords(s): Antibodies, Autoimmune Diseases, Biologics, Cancers, Combination, Disease Indication, Inflammatory Disorders, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies

Manipulation of Regulatory T Cell and DC Function by Targeting Neuritin Gene Using Antibodies, Agonists and Antagonists

Unmet NeedThe recent breakthroughs in immuno-oncology have changed the way that researchers think about treating autoimmune diseases and cancer by modulating the immune system. Regulatory T cells (Treg) limit autoimmunity but also attenuate the potency of antitumor immunity. Enhancement of Treg function could treat autoimmune diseases while the inhibition...

Published: 3/13/2025 | Inventor(s): Drew Pardoll, Joseph Barbi, Fan Pan, Hong Yu, Ching-Tai Huang, Xiaoyu Pan, Charles Drake, Jonathan Powell

Keywords(s): Antibodies, Biologics, Cancers, Disease Indication, Immunotherapy, Infectious Diseases, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics

Topological Insulator-Based High Efficiency Switching of Magnetic Unit, Method and Application

Unmet Need: The invention meets the need for improved magnetic random access memory, racetrack memory, and spin logic devices. The present state of the art of electrical current by spin-orbital torque (SOT) consists of a single heavy metal layer (e.g., W or Ta) in contact with a ferromagnetic layer, which acquires perpendicular magnetic moment suitable...

Published: 3/13/2025 | Inventor(s): Yufan Li, Qinli Ma, Chia-Ling Chien

Keywords(s): Electric Communication Technique, Electricity, Industrial Manufacturing, Insulative Materials (Insulators), Novel Materials, Semiconductive Materials (Semiconductors), Topological Insulators

Category(s): Technology Classifications > Industrial Tech > Energy, Infrastructure & Environment, Technology Classifications > Industrial Tech, Technology Classifications > Industrial Tech > Materials, Technology Classifications > Engineering Tech > Materials

Skyrmion-based Universal Memory Operated by Electric Currents

Unmet Need Modern computer rely on a hierarchy of several storage devices. Universal memory combines the advantages of the multiple storage devices and possesses non-volatility, high speed, ultra density, and infinite durability. Skymions can be used for universal memory, because of their small size, stability, individual creation and annihilation,...

Published: 3/13/2025 | Inventor(s): Roger Lake, Yufan Li, Chia-Ling Chien, Gen Yin, Jiadong Zang

Keywords(s): Electric Communication Technique, Electricity, Industrial Manufacturing, Magnetic Materials (Magnets), Novel Materials

Category(s): Technology Classifications > Industrial Tech > Energy, Infrastructure & Environment, Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Industrial Tech > Materials, Technology Classifications > Industrial Tech, Technology Classifications > Engineering Tech > Energy, Infrastructure & Environment, Technology Classifications > Engineering Tech > Industrial Manufacturing, Technology Classifications > Engineering Tech > Materials

A Microfabricated Multiple Actuation Device for Mechanical Conditioning of 3D Microtissues

We have recently demonstrated an approach that enables mechanical stimulation of microtissues via magnetic actuation of magnetic microspheres bonded to one of the cantilevers in each device (ALL THREE ZHAO REFS). This has notably allowed measurement of the mechanical stiffness of such constructs, and hence analysis of the relative contribution of cells...

Published: 3/13/2025 | Inventor(s): Fan Xu, Ruogang Zhao, Tristin Metz, Alan Liu, Yu Shi, Daniel Reich

Keywords(s): Implanted Device, Implants, Therapeutic Devices, Therapeutic Method, Therapeutics, Tissue Engineering/Regenerative Devices

Category(s): Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices

A Microfabricated Multiple Actuation Device for Mechanical Conditioning of 3D Microtissues

Published: 3/13/2025 | Inventor(s): Fan Xu, Ruogang Zhao, Tristin Metz, Alan Liu, Yu Shi, Daniel Reich

Keywords(s): Implanted Device, Implants, Therapeutic Devices, Therapeutic Method, Therapeutics, Tissue Engineering/Regenerative Devices

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