Search Results - clinical+and+disease+specializations+%3e+hematology

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Compact Capillaroscope for Non-invasive Blood Analysis

Unmet NeedAnalysis of a complete blood count (CBC) test can help detect a plethora of diseases and conditions including leukemia, anemia, and blood infections. The information gained from a CBC analysis helps doctors treat any unusual symptoms, reduce risk of disease or complications, or simply help the patient make decisions to optimize their health....

Published: 6/28/2024 | Inventor(s): Nicholas Durr, Gregory McKay

Keywords(s):

Category(s): Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Diagnostics > In Vivo Diagnostics, Clinical and Disease Specializations > Hematology, Technology Classifications > Medical Devices > Imaging

The Development of a Mini-scale Euglobulin Clot Lysis Assay

Unmet Need· A large proportion of patients with bleeding disorders fail to be diagnosed, and are classified as having bleeding of unknown cause due to a lack of sensitive assays for detecting abnormalities in fibrinolytic factors (Mehic et al. 2021). In addition, patients with young-onset or unprovoked venous thromboembolism, as well as those...

Published: 6/28/2024 | Inventor(s): Neil Goldenberg, Vera Ignjatovic, Steven Bruzek

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Diagnostics > In Vitro Diagnostics, Clinical and Disease Specializations > Cardiovascular, Clinical and Disease Specializations > Fibrosis, Clinical and Disease Specializations > Hematology, Clinical and Disease Specializations > Pediatrics

Multiplex Mass Spectrometry Assay on a Pentaflouropropyl (PFPP) Stationary Phase

Dried blood spot (DBS) tests are an important diagnostic tool used for newborns. Unfortunately DBS has a variety limitations. According to the CDC, approximately four million DBS tests are required for infants are born in the United States each year. Conventional newborn screening with DBS begins with the addition of capillary blood droplets from a...

Published: 6/28/2024 | Inventor(s): David Graham, Aurelie Roux, Robert Harlan

Keywords(s):

Category(s): Clinical and Disease Specializations > Hematology, Technology Classifications > Diagnostics > Companion Diagnostics, Technology Classifications > Research Tools > Blood & Tissue Samples, Technology Classifications > Diagnostics

Aldehyde Dehydrogenase Activity Distinguishes Leukemia Stem Cells from Normal Hematopoietic Stem Cells in Acute Myeloid Leukemia

Using the methods of the present invention, intermediate (int) levels of aldehyde dehydrogenase (ALDH) activity reliably distinguished leukemic CD34+CD38? cells capable of engrafting immunodeficient mice, from residual normal hematopoietic stem cells that exhibited relatively higher ALDH activity. Minimal residual disease (MRD) detected during complete...

Published: 6/27/2024 | Inventor(s): Richard Jones, Jonathan Gerber

Keywords(s): Acute Myeloid Leukemia, Biomarker, Cancers, Clinical Diagnostics, Disease Indication, Hematologic Malignancies, In Vitro Diagnostics, Leukemia, Mechanism-of-action Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Hematology, Clinical and Disease Specializations > Oncology > Acute Myeloid Leukemia, Clinical and Disease Specializations > Oncology > Hematologic Malignancies, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology

FLT3/ITD Mouse Model for Acute Myeloid Leukemia (AML)

Unmet Need: Constitutive activation of FMS-like tyrosine kinase 3 (FLT3) by internal tandem duplication (ITD) mutations is one of the most common molecular alterations known in acute myeloid leukemia (AML). To investigate the role FLT3/ITD mutations play in the development of leukemia, we generated a FLT3/ITD knock-in mouse model by inserting an ITD...

Published: 6/27/2024 | Inventor(s): Donald Small

Keywords(s): Acute Myeloid Leukemia, Blood Cancer, Cancers, Discovery/Research Tools, Disease Indication, Hematologic Malignancies, In Vivo Research Tool, Knock In Mouse Model, Mouse Model

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Hematology, Clinical and Disease Specializations > Oncology > Acute Myeloid Leukemia, Clinical and Disease Specializations > Oncology > Hematologic Malignancies, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

C09948: A Mouse Model of Hemophilia A

Overview: These knock-out mice are deficient of endogenous Factor VIII making them useful for hemophilia A studies. The mice are available via The Jackson Laboratory Strain: 004424; B6;129S4-F8tm1Kaz/JTechnical DetailsMice that are homozygous for the targeted, X chromosome-linked mutant allele are viable and fertile. Homozygous females and carrier males...

Published: 6/27/2024 | Inventor(s): Haig Kazazian, John Gearhart, Ann Lawler, Lilia Bi

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Disease Indication, Genetic Disorders, Hemophilia, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases > Hemophilia, Clinical and Disease Specializations > Hematology, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools

Aptamer Based Sickle Cell Anemia Therapeutic

INVENTION NOVELTY: This technology is a set of RNA aptamers capable of reducing sickle hemoglobin (HbS) polymerization, which has therapeutic potential in reducing vaso-occlusion and ischemia in sickle cell disease patients. VALUE PROPOSITION: Sickle cell anemia is a genetically inherited disease affecting 1 in 400 African American and up to 2% of the...

Published: 6/27/2024 | Inventor(s): James Casella, Shirley Purvis, Emily Barron-Casella, Yolanda Fortenberry, Jeffrey Keefer

Keywords(s): Biologics, Disease Indication, Genetic Disorders, Nucleic Acid, Sickle Cell Anemia, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases > Sickle Cell Anemia, Clinical and Disease Specializations > Hematology, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities

Derivation and Validation of a Novel Method for More Accurate Estimation of Low-Density Lipoprotein Cholesterol from the Standard Lipid Profile

C12643: Derivation and Validation of a Novel Method for More Accurate Estimation of Low-Density Lipoprotein Cholesterol from the Standard Lipid ProfileNovelty: A novel, accurate method for LDL-C estimation from the standard lipid profile using an adjustable factor for the triglycerides to very low-density lipoprotein cholesterol (TG:VLDL-C) ratioValue...

Published: 6/27/2024 | Inventor(s): Seth Martin, Steven Jones

Keywords(s): Assay, Blood Disorder, Clinical Diagnostics, Diagnostic Tool, Disease Indication, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Hematology, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

A Genetic Assay to Determine Prognosis in Polycythemia vera Patients

C12165: Genetic Biomarker Prognostic Screen for Polycythemia Vera PatientsNovelty: The technology is a PCR-based screening assay based on identified genetic biomarkers to determine prognosis in polycythemia vera patients.Value Proposition: Polycythemia vera (PV) is a blood cell disorder complicated by the risk of disease progression into acute myeloid...

Published: 6/27/2024 | Inventor(s): Michael Ochs, Michael Considine, Alison Moliterno, Donna Rowley, Jerry Spivak

Keywords(s): Biomarker, Blood Disorder, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Polycythemia Vera, Polycythemia vera (PV), Risk Stratification

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Hematology > Polycythemia Vera, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Hematology

Hemophilia A inbred mouse

C11950: Novel Inbred Mouse Model of Hemophilia ANovelty: This invention is a transgenic inbred mouse model of Hemophilia A.Value Proposition: Currently available natural canine models of Hemophilia A are ineffective in designing gene therapy for the disease. There is a need for a mouse model to study the Factor VIII gene (Factor VIII deficiency causes...

Published: 6/27/2024 | Inventor(s): Haig Kazazian

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Disease Indication, Genetic Disorders, Hemophilia, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model

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