Search Results - clinical+and+disease+specializations+%3e+metabolic+diseases

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Monoclonal Antibodies Specific to AGK, for Research Purposes

Unmet Need: Acylglycerol kinase, AGK, is a protein in the TIMM22 translocon and is postulated to be important in cardiolipin biogenesis. Mutations in the gene encoding for AGK also can result in human disease, making the study of the protein important in understanding disease pathogenesis. Currently there are no validated human AGK specific antibodies,...

Published: 9/27/2024 | Inventor(s): Steven Claypool

Keywords(s):

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Research Antibodies, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Metabolic Diseases

Monoclonal Antibody Specific to Human ANT1, for Research Purposes

Unmet Need: ANT1, also known as solute carrier family 25 member 4 (SLC25A4), is a protein important for mitochondrial energy production and is relevant in the research of human mitochondrial diseases. Mutations in the gene encoding for ANT1 also can result in human disease, making the study of the protein important in understanding disease pathogenesis....

Published: 9/27/2024 | Inventor(s): Steven Claypool

Keywords(s):

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Research Antibodies, Technology Classifications > Research Tools > Antibodies, Clinical and Disease Specializations > Metabolic Diseases

Non-invasive Diagnostic Biomarker for Pancreatic Islet Populations

Unmet NeedAffecting more than 230 million people worldwide, diabetes is a chronic disease caused by a deficiency and/or resistance to insulin. Insulin production is controlled by the pancreas, specifically by the pancreatic islets, a region of the pancreas that contains the hormone-producing cells. The pancreatic islets are made up of at least 5 different...

Published: 9/26/2024 | Inventor(s): Richard Edden, Eric Porges, Damon Lamb, Martha Thompson

Keywords(s): Biomarker, Clinical Diagnostics, Diabetes, Diagnostic Biomarker, Disease Indication, Image Processing Software, Imaging and Sensing Systems, In Vitro Diagnostics, In Vivo Medical Imaging, Metabolic Disorders

Hepatic Kisspeptin Secretion Impairs Insulin Secretion from Pancreatic Bets Cell. Kisspeptin Receptor GPR54 Antagonist for Treatment of Prediabetes and Diabetes Mellitus in Humans.

Unmet NeedGlucagon and insulin work together to keep blood glucose levels balanced. Glucagon stimulates the liver to secrete glucose while insulin suppresses glucose release. If the body does not regulate glucose levels properly, Type 2 diabetes mellitus (T2DM) will develop. Type 2 diabetes mellitus is a world-wide epidemic, projected to affect 1/3...

Published: 9/26/2024 | Inventor(s): Woo-Jin Song, Prosenjit Mondal, Mehboob Hussain

Keywords(s): Biomarker, Diabetes, Disease Indication, Mechanism-of-action Biomarker, Metabolic Disorders, Therapeutic Matter, Therapeutics, Type 2 Diabetes, Type II Diabetes

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Metabolic Diseases, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Diabetes, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Diabetes > Type 2 Diabetes

Methods and Kits for Identifying Autoreactive Lymphocytes in Type 1 Diabetes and Other Autoimmune Disease

Unmet NeedAutoreactive lymphocytes contribute to the pathogenesis of autoimmune diseases including, type 1 diabetes, multiple sclerosis, and systemic lupus erythematosus (SLE). One of the challenges in studying these populations of lymphocytes, also known as X- cells, is that there are no biomarkers to distinguish them from protective T cells and B...

Published: 9/26/2024 | Inventor(s): Abdel Rahim Hamad, Thomas Donner, Rizwan Ahmed, Zahra Omidian

Keywords(s): Biomarker, Clinical Diagnostics, Diabetes, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Metabolic Disorders

An Insulin-loaded Nanoparticle and the Method for Preparing Thereof

Unmet Need:Repeated injections of insulin is the standard of care for treating Type 1 diabetes, and essential for control and management of Type 2 diabetes. Drawbacks of this treatment include poor patient compliance, discomfort, and an impaired lifestyle, and hypoglycemia. Oral administration of insulin, if successful, could deliver insulin such that...

Published: 9/26/2024 | Inventor(s): Hai-Quan Mao, Jose Santos, Zhiyu He, Huahua Huang, Lixin Liu, Kam Leong, Yongming Chen

Keywords(s): Diabetes, Disease Indication, Drug Delivery Vehicle, Metabolic Disorders, Nanoparticles, Therapeutic Matter, Therapeutic Method, Therapeutics

Use of C1q/TNF-related Protein-1 (CTRP1) to Treat Fatty Liver Disease (steatosis)

Unmet NeedObesity is a leading preventable cause of death worldwide, and it is associated with a number of comorbidities, including Non-alcoholic Fatty Liver Disease (NAFLD). Fatty liver is the accumulation of triglycerides and other fats in the liver cells. The amount of fatty acid in the liver depends on the balance between the processes of delivery...

Published: 9/26/2024 | Inventor(s): Guang Wong, Susana Rodriguez

Keywords(s): Biologics, Disease Indication, Metabolic Disorders, Natural compounds, Non-novel, Predicted Novelty, Protein, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Metabolic Diseases, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities

High-throughput in vivo screening platform for chemical and genetic modulators of Apoliprotein-B

Unmet Need: Rapid and sensitive screening platform to develop diagnostic tests for metabolic diseases.Technology Overview: Elevated serum Apolipoprotein-B (ApoB) may represent a unifying risk factor underlying many of the world’s most prevalent metabolic diseases. ApoB levels independently predict incidence of diabetes, metabolic syndrome, and cardiovascular...

Published: 9/26/2024 | Inventor(s): James Thierer, Steven Farber

Keywords(s): Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Metabolic Disorders, Target-based Screening Tool

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Metabolic Diseases

Three-dimensional Vascular Network Assembly from Diabetic Patient-derived Induced Pluripotent Stem Cells

In diabetics, hyperglycemia results in deficient endothelial progenitors and cells, leading to cardiovascular complications. We aim to engineer three-dimensional (3D) vascular networks in synthetic hydrogels from type-1 diabetes (T1D) patient-derived human induced pluripotent stem cells (hiPSCs), thus serving as a transformative autologous vascular...

Published: 9/26/2024 | Inventor(s): Sharon Gerecht, Xin Yi Chan, Quinton Smith, Yu-I Shen

Keywords(s): Biologics, Cell Model, Diabetes, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Metabolic Disorders, Stem Cells, Therapeutic Matter, Therapeutic Substance, Therapeutic Substance Synthesis Method, Therapeutics, Translational Research Biomarker, Whole cell

Compounds and Methods to Decrease Obesity-related Hepatic Fat Accumulation and Serum Glucose

Technology DescriptionResearchers at Johns Hopkins have identified that valproic acid (VPA) and its metabolites may be useful for the treatment of obesity and related metabolic diseases (e.g., type 2 diabetes, fatty liver disease).VPA and its cytochrome P450- and beta-oxidation-dependent metabolites activate AMP-activated protein kinase (AMPK), which...

Published: 9/26/2024 | Inventor(s): Lindsay Avery, Namandje Bumpus

Keywords(s): Agonists/Promoters, Disease Indication, Metabolic Disorders, Non-novel, Obesity, Predicted Novelty, Repurposed, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Metabolic Diseases > Obesity, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Metabolic Diseases, Technology Classifications > Therapeutic Modalities

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