Search Results - clinical+and+disease+specializations+%3e+metabolic+diseases+%3e+obesity

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Sustained release formulations for fat reduction

JHU Ref #: C18159Value Proposition· Sustained release of small molecule that depletes white fat· Local injectable administration with less intense dosing regimenUnmet Need· Excessive white fat accumulation, commonly associated with obesity, is a significant health concern that impacts metabolic, cardiovascular, and endocrine systems....

Published: 3/14/2025 | Inventor(s): Laura Ensign-Hodges, Yub Raj Neupane, Fatemeh Rajaii

Keywords(s):

Category(s): Clinical and Disease Specializations > Endocrinology > Thyroid Disorders, Clinical and Disease Specializations > Metabolic Diseases > Obesity, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Small Molecules

Compounds and Methods to Decrease Obesity-related Hepatic Fat Accumulation and Serum Glucose

Technology DescriptionResearchers at Johns Hopkins have identified that valproic acid (VPA) and its metabolites may be useful for the treatment of obesity and related metabolic diseases (e.g., type 2 diabetes, fatty liver disease).VPA and its cytochrome P450- and beta-oxidation-dependent metabolites activate AMP-activated protein kinase (AMPK), which...

Published: 3/13/2025 | Inventor(s): Lindsay Avery, Namandje Bumpus

Keywords(s): Agonists/Promoters, Disease Indication, Metabolic Disorders, Non-novel, Obesity, Predicted Novelty, Repurposed, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Metabolic Diseases > Obesity, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Metabolic Diseases, Technology Classifications > Therapeutic Modalities

A Novel Obesity Model: Human Synphilin-1 Transgenic Mouse

Invention novelty: The technology is a transgenic mouse strain (SP1) utilizing synphilin-1 to control food intake and body weight thus providing a convenient model for obesity studies.Value Proposition: The technology provides a unique genetic obesity model for future studies of the pathogenesis of obesity and related disorders.Key features include:-...

Published: 3/13/2025 | Inventor(s): Christopher Ross, Timothy Moran, Wanli Smith

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Metabolic Disorders, Mouse Model, Mouse Model Xenograft, Obesity

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Metabolic Diseases > Obesity, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Metabolic Diseases, Technology Classifications > Research Tools

Novel Protein Therapeutic for Diabetes and Obesity

Novelty: This technology identifies a novel myonectin protein, which links skeletal muscle to metabolic regulation. Myonectin was found to lower circulating free fatty acid levels by promoting lipid uptake. Value Proposition: Type-2 diabetes, obesity, and metabolic syndrome are diseases that dramatically reduce patient quality of life and lead...

Published: 3/13/2025 | Inventor(s): Marcus Seldin, Guang Wong

Keywords(s): Biomarker, Diabetes, Disease Indication, Mechanism-of-action Biomarker, Metabolic Disorders, Obesity, Therapeutic Matter, Therapeutics, Type II Diabetes

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Metabolic Diseases, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Metabolic Diseases > Obesity, Clinical and Disease Specializations > Diabetes > Type 2 Diabetes

Germline and Conditional Deletion of Tardbp

C11168: A Gene Linked to Obesity, and Alters Body Fat Metabolism Value Proposition: • Identifies novel therapeutic target to control obesity and diabetes. • Helps to understand incurable diseases: frontal temporal dementia and amyotrophic lateral sclerosis. Technical Details: JHU scientists have developed conditional knockout mice...

Published: 3/13/2025 | Inventor(s): Donald Price, Po-Min Chiang, Philip Wong

Keywords(s): Amyotrophic Lateral Sclerosis, Basic Research Biomarker, Biomarker, Cell Model, Clinical Diagnostics, CNS and Neurological Disorders, Dementia, Diabetes, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, In Vivo Research Tool, Knock Out Mouse Model, Mechanism-of-action Biomarker, Metabolic Disorders, Mouse Model, Neurodegeneration, Obesity, Stem Cells

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Diabetes, Clinical and Disease Specializations > Metabolic Diseases, Clinical and Disease Specializations > Metabolic Diseases > Obesity, Clinical and Disease Specializations > Neurology > Amyotrophic Lateral Sclerosis, Clinical and Disease Specializations > Neurology > Dementia, Clinical and Disease Specializations > Neurology > Neurodegeneration, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Stem Cells