Search Results - clinical+and+disease+specializations+%3e+obesity

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Detecting diseases in subjects using extracelluar vesicles

Value Proposition:· Minimally invasive diagnostic platform that detects miRNAs within circulating cell-type-specific extracellular vesicles (EVs).· Low-cost testing platform (~20$/test) that provides rapid results (within 3h), optimized for at-home collection of blood samples.· Diverse applications across multiple disease indications,...

Published: 3/14/2025 | Inventor(s): Samarjit Das

Keywords(s):

Category(s): Clinical and Disease Specializations > Diabetes, Clinical and Disease Specializations > Obesity, Technology Classifications > Medical Devices, Technology Classifications > Diagnostics

Novel peptides for treating and preventing metabolic diseases

Value Proposition:· Drug treats mitochondrial dysfunction by promoting mitochondrial fission and mitophagy. · Decreases fat levels and represses glucose production in the liver to effectively treat diabetes, obesity, and non-alcoholic fatty liver disease.· Possesses antitumor activity via p53-mediated apoptosis Unmet Need· Approximately...

Published: 3/14/2025 | Inventor(s): Ling He

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Obesity, Clinical and Disease Specializations > Diabetes

Treatment of Post-menopausal Obesity and Associated Disease by PDE9 Inhibitors

Unmet NeedObesity is a serious health problem both globally and in the United States. Obesity is associated with numerous comorbidities including type-2 diabetes, cardiovascular disease, and certain types of cancers. In particular, obesity is commonly seen in the post-menopausal population as 74% of American women over the age of 60 are considered overweight....

Published: 3/14/2025 | Inventor(s): David Kass, Dong Ik Lee, Sumita Mishra

Keywords(s): Antagonists/Inhibitors, Disease Indication, Metabolic Disorders, Obesity, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Obesity

Supramolecular Hydrogel Applications to the Carotid Bodies to Treat Hypertension and Sleep Apnea in Obesity

Unmet NeedOver one-third of adults in the U.S. (36.5%) have obesity. Further, obesity leads to increased cardiovascular morbidity and mortality via multiple adverse mechanisms that include increased prevalence and severity of hypertension (often resistant to treatment) and obstructive sleep apnea (OSA). Currently, no pharmacotherapy exists for OSA....

Published: 3/13/2025 | Inventor(s): Vsevolod Polotsky, Honggang Cui, Roxana Mitrut, Mi-kyung Shin

Keywords(s): Cardiovascular Diseases, CNS and Neurological Disorders, Disease Indication, Drug Delivery Vehicle, Hypertension, Metabolic Disorders, Obesity, Peptides/Prodrugs, Sleep Apnea, Sleep Disorders, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Cardiovascular > Hypertension, Clinical and Disease Specializations > Sleep Disorders > Sleep Apnea, Clinical and Disease Specializations > Obesity

12612 B6.129-Gria1/J; 12613 B6.129-Gria1/J; 12614 B6.129-Gria1/J; 12615 B6.129-Gria2/J; 12616 B6.129-Gria3/J; 12617 B6.129-Gria3tm2R1h/J; 12618 B6.129-Gria4/J; 12619 B6.129-Gria4tm1R1h/J

C11079: Transgenic Gria mouse strains.Value Proposition: Transgenic Gria mouse strains: • 12612 B6.129-Grial/J • 12613 B6.129-Grial/J • 12614 B6.129-Grial/J • 12615 B6.129-Gria2/J • 12616 B6.129-Gria3/J • 12617 B6.129-Gria3tm2Rlh/J • 12618 B6.129-Gria4/J • 12619 B6.129-Gria4tmlRlh/J Published...

Published: 3/13/2025 | Inventor(s): Richard Huganir

Keywords(s): Addiction, Basic Research Biomarker, Cell Lines, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, In Vivo Research Tool, Knock In Mouse Model, Metabolic Disorders, Mouse Cell Lines, Mouse Model, Obesity

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Obesity