Search Results - clinical+and+disease+specializations+%3e+ophthalmology+%3e+corneal+dystrophy

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Alpha 2 Collagen VIII (Col8a2) Q455K Knock-in Mouse Model of Fuchs Endothelial Corneal Dystrophy

Unmet Need:Fuchs’ endothelial corneal dystrophy (FECD) is a genetic disease affecting the cornea and is estimated to affect 7% of the adult population (see Aiello et al. 2022). The first genetic defect shown to cause FECD was a point mutation in the alpha 2 collagen 8 gene (Col8a2). The disease results in a buildup of fluid in the cornea and causes...

Published: 3/13/2025 | Inventor(s): Albert Jun

Keywords(s): Basic Research Biomarker, Cell Lines, Corneal Dystrophy, Discovery/Research Tools, Disease Indication, Eye Disorders, Fuchs' Endothelial Corneal Dystrophy, Fuchs Endothelial Corneal Dystrophy (FECD), In Vitro Research Tool, Mouse Cell Lines

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Ophthalmology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Ophthalmology > Corneal Dystrophy, Clinical and Disease Specializations > Ophthalmology > Fuchs' Endothelial Corneal Dystrophy

Generation of PBMC-Originated, iPSC-Derived Corneal Endothelial Cells

Unmet NeedFuchs’ dystrophy, a progressive, hereditary disease of the cornea, is the leading cause of corneal transplants both in the US and worldwide. The disease results in the dysregulation and destruction of corneal endothelial cells which are responsible for keeping the eye properly hydrated. As the disease progresses, patients will experience blurred...

Published: 3/14/2025 | Inventor(s): Sheikh Amer Riazuddin, John Gottsch, Shahid Khan, Muhammad Ali

Keywords(s): Biologics, Cell Therapy, Corneal Dystrophy, Disease Indication, Eye Disorders, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Whole cell

Category(s): Clinical and Disease Specializations > Ophthalmology > Corneal Dystrophy, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Research Tools > Research Stem Cells

A novel device to facilitate performing Descemet's Membrane Endothelial Keratoplasty (DMEK)

Unmet NeedOver 3 million U.S. patients suffer from severe eye pain and possible blindness due to corneal dystrophies, which can only be cured by corneal transplants. Corneal transplantation can be performed through surgical procedures known as Descemet’s Stripping Automated Endothelial Keratoplasty (DSAEK) and Descemet’s Membrane Endothelial Keratoplasty...

Published: 3/13/2025 | Inventor(s): Eric Chiang, Kali Barnes, Conan Chen, Anshul Subramanya, Stephanie Cai, Allen Eghrari

Keywords(s): Carriers/Appliers, Corneal Dystrophy, Disease Indication, Eye Disorders, Interventional and Surgical Systems, Surgical Instruments

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Ophthalmology, Clinical and Disease Specializations > Ophthalmology > Corneal Dystrophy

Alpha 2 Collagen VIII (Col8a2) L450W Knock-in Mouse Model of Fuchs Endothelial Corneal Dystrophy

Alpha 2 Collagen VIII (Col8a2) L450W Knock-in Mouse Model of Fuchs Endothelial Corneal DystrophyJHU REF: C13003Invention novelty: This tangible material is an Alpha 2 collagen VIII (Col8a2) L450W knock-in mouse model of Fuchs endothelial corneal dystrophy (FECD)Value PropositionFuchs endothelial corneal dystrophy (FECD) is a progressive, hereditary...

Published: 3/13/2025 | Inventor(s): Albert Jun

Keywords(s): Basic Research Biomarker, Corneal Dystrophy, Discovery/Research Tools, Disease Indication, Eye Disorders, Fuchs' Endothelial Corneal Dystrophy, Fuchs Endothelial Corneal Dystrophy (FECD), In Vivo Research Tool, Knock In Mouse Model, Mouse Model

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Ophthalmology > Corneal Dystrophy, Clinical and Disease Specializations > Ophthalmology > Fuchs' Endothelial Corneal Dystrophy, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Ophthalmology, Technology Classifications > Research Tools