Search Results - positron+emission+tomography+(pet)

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11C-PABA as a Novel Functional Renal Imaging Agent

Unmet Need: Assessing kidney function is often essential for clinical decision making for a variety of diseases including chronic kidney disorder (CKD). CKD affects more than 30 million Americans and millions of others are at an increased risk of developing it. The gold standard for measuring renal function for diagnosing/monitoring CKD and other disorders...

Published: 6/20/2024 | Inventor(s): Sanjay Jain, Alvaro Ordonez, Camilo Ruiz-Bedoya

Keywords(s): Disease Indication, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Kidney Disorders, Positron Emission Tomography (PET)

Category(s): Technology Classifications > Diagnostics > Diagnostic Imaging, Clinical and Disease Specializations > Nephrology

FDG PET Metabolic Tumor Volume: Method for Identifying the Optimum Segmentation Method for Human Solid Tumors

Unmet Need:The use of quantitative metrics derived from PET images to help make clinical decisions, has shown tremendous promise. Examples of such metrics include standardized uptake value (SUV), total lesion glycolysis, and metabolic tumor volume. Quantitative FDG-PET imaging has been shown to separate responders from nonresponders early in a treatment...

Published: 6/20/2024 | Inventor(s): Abhinav Jha, Rathan Subramaniam, Eric Frey

Keywords(s): Image Processing Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Pattern Recognition Software, Positron Emission Tomography (PET)

Category(s): Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices

Intranasal Administration of Glutamate Carboxypeptidase (GCP-II) Inhibitors for Enhanced Brain Delivery

Inventors have developed a novel method to enhance the penetrance of multiple GCPII inhibitors which were developed by the inventor and Dr. Pomper at JHU. This method demonstrated improved brain penetrance in rodents. The penetrance of a specific GCPII inhibitor showed significant brain penetrance in non-human primates and inhibited GCPII activity in...

Published: 6/20/2024 | Inventor(s): Rana Rais, Barbara Slusher

Keywords(s): Biologics, CNS and Neurological Disorders, Disease Indication, Drug Delivery Mechanism, Enzyme, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Intranasal Administration, Multiple CNS Indications, Positron Emission Tomography (PET), Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities

New Scaffolds and Multifunctional Intermediates for Imaging PSMA

The prostate-specific membrane antigen (PSMA) is increasingly recognized as an important target for cancer imaging and therapy. Current PSMA inhibitors based on a urea scaffold have shown good results for imaging with positron emission tomography (PET) and single photon emission computed tomography (SPECT) in human subjects. The urea scaffold has...

Published: 6/20/2024 | Inventor(s): Martin Pomper, Ying Chen, Sangeeta Ray, Ronnie Mease, Xing Yang, Georgio Attardo

Keywords(s): Cancers, Disease Indication, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Positron Emission Tomography (PET), Prostate Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Oncology

A pulse pileup effects compensation method for photon counting detectors (PCDs)

Unmet NeedPhoton counting x-ray detectors (PCSD) can potentially boost the usefulness of clinical x-ray computed tomography (CT) scanners by efficiently measuring x-ray spectrum information, i.e., improved contrast-to-noise ratio in images, reduced radiation dose, and improved material decomposition. A major hindrance to their adoption in the clinical...

Published: 6/20/2024 | Inventor(s): Katsuyuki Taguchi

Keywords(s): Image Processing Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Positron Emission Tomography (PET), Single-Photon Emission Computed Tomography (SPECT)

[11C]MCG For Imaging NAALADase/PSMA

The present invention relates to compounds particularly asymmetric urea compounds which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express NAALADase and/or PSMA. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors...

Published: 6/20/2024 | Inventor(s): John Musachio, Alan Kozikowski, Jiazong Zhang, Martin Pomper

Keywords(s): CNS and Neurological Disorders, Disease Indication, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Positron Emission Tomography (PET)

PSMA-based Molecular-genetic Reporter System

PSMA-based Molecular-genetic Reporter SystemJHU REF: C12881Invention Novelty: A method of using the prostate-specific membrane antigen (PSMA) in combination with molecular reporting systems as an expression system to deliver the PSMA gene for diagnosis and imaging of prostate cancer.Value Proposition:PSMA is ideally suited to becoming a reporter because...

Published: 6/20/2024 | Inventor(s): Martin Pomper, Shawn Lupold, Mark Castanares, Il Minn

Keywords(s): Antigens, Basic Research Biomarker, Cancers, Cell Signaling, Discovery/Research Tools, Disease Indication, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Positron Emission Tomography (PET), Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Medical Devices, Technology Classifications > Research Tools

PERCISTz: A Method for the Quantitative Assessment of Disease Response using Medical Image Data.

C11731: Medical Image Analysis and Diagnosis Improvement ToolsNovelty: This technology bundle is a set of processing tools for medical image analysis.Value Proposition: The current invention is a suite of tools for improving diagnoses from medical images, involving three separate technologies. Currently, there is a need for precise, quantitative medical...

Published: 6/20/2024 | Inventor(s): Richard Wahl, Jeffrey Leal

Keywords(s): Disease Indication, Image Display Software, Image Processing Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Positron Emission Tomography (PET)