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Methods for Clearing and Molecular Analysis in Thick Tissue Sections

Unmet Need· Current techniques for in situ transcriptomics (or spatial transcriptomics) are effectively limited to thin tissue sections of approximately 15 microns due to the poor molecular diffusion and opacity of thicker tissues. Consequently, these techniques are unable to resolve spatial variation of transcription in 3D. Thus, there is a need...

Published: 6/28/2024 | Inventor(s): Reza Kalhor, Soichiro Asami

Keywords(s):

Category(s): Technology Classifications > Research Tools > Blood & Tissue Samples, Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools > Specimen Handling, Technology Classifications > Research Tools > Assays

DNA Oligonucleotide Buffers

Unmet Need: A topic of research interest in the near past has been utilizing DNA as data storage, process information, and even use DNA in logic circuits. However, these applications require precise control over the chemical process responsible for storing, accessing and deleting data. Since the rate of a chemical process is usually dependent on the...

Published: 6/27/2024 | Inventor(s): Rebecca Schulman, Dominic Scalise, Samuel Schaffter

Keywords(s): Buffer Solution, Buffer/Media Solution, Discovery/Research Tools, Research Reagent

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions

Novel Hexosamine Reagents for Improved Quality Recombinant Glycoprotein Production

Unmet Need: Glycosylation has a major impact on recombinant glycoproteins with important implications for increasing therapeutic use of these compounds. Various approaches are being developed to afford scientists and engineers more control over the type, location, and amount of sugar added to the protein. One technique involves adding sugar reagents...

Published: 6/27/2024 | Inventor(s): Ruben Almaraz, Udayanath Aich, Kevin Yarema

Keywords(s): Buffer/Media Solution, Discovery/Research Tools, Research Reagent, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools

Guiding the Derivation of Endothelial Cells from Human Pluripotent Stem Cells in a Two-dimensional, Feeder Free Differentiation Scheme

New defined chemical method for growth of endothelial cells from human stem cellsJHU REF: [C11924]Invention novelty: Development of defined chemical conditions and method for culturing of endothelial cells (ECs) from human embryonic and induced pluripotent stem cells using sequential adherent cell culture method. Value PropositionThe development of...

Published: 6/27/2024 | Inventor(s): Sravanti Kusuma, Sharon Gerecht

Keywords(s): Buffer/Media Solution, Cell Model, Culture Media, Discovery/Research Tools, In Vitro Research Tool, Research Reagent, Stem Cells, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools

A Platform for Creating an Artificial Blood Brain Barrier

C12117 A Platform for Creating an Artificial Blood Brain BarrierInvention novelty: This invention provides a platform for developing a three-dimensional in vitro model of blood brain barrier (BBB).Value Proposition: The BBB is a dynamic interface that is responsible for maintaining homeostasis of the brain. Disruption of the BBB is associated with many...

Published: 6/27/2024 | Inventor(s): Peter Searson, Andrew Wong

Keywords(s): Basic Research Biomarker, Buffer/Media Solution, Culture Media, Discovery/Research Tools, Research Reagent

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools

Engineered Heart Slices

Engineered Heart SliceJHU REF: C12744Invention Novelty: A novel method of producing acellular cardiac tissue scaffolds with stem-cells for tissue regeneration productsValue Proposition: Tissue constructs using cardiac cells and a base matrix have been developed in the past, and several methods of creating these constructs have been described. However...

Published: 6/27/2024 | Inventor(s): Adriana Blazeski, Leslie Tung

Keywords(s): Basic Research Biomarker, Buffer/Media Solution, Culture Media, Discovery/Research Tools, Research Reagent

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools, Clinical and Disease Specializations > Cardiovascular

A High-efficiency Inducible Cell-cell Fusion Culture System

C11722: High-efficiency Inducible Cell Fusion Culture SystemNovelty: This invention embodies a new culture system that induces cell-cell fusion in transfected cells with high efficiency. In addition to the newfound ability to fuse normally non-fusing Drosophila S2R+ cells, this system provides insight into the mechanisms and interactions involved in...

Published: 6/27/2024 | Inventor(s): Khurts Shilagardi, Peng Jin, Elizabeth Chen

Keywords(s): Basic Research Biomarker, Buffer/Media Solution, Culture Media, Discovery/Research Tools, Research Reagent

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools

The New Culture Method of Rat Distal Pulmonary Vein Smooth Muscle Cell

C10362: The New Culture Method of Rat Distal Pulmonary Vein Smooth Muscle CellValue Proposition: Isolation of primary cell populations is complex and requires a significant amount of technical expertise to produce purified and viable cultures. JHU scientists have developed an optimized method to produce a highly purified population of mammalian intrapulmonary...

Published: 6/27/2024 | Inventor(s): Gongyong Peng, Wenju Lu, Jian Wang

Keywords(s): Basic Research Biomarker, Buffer/Media Solution, Culture Media, Discovery/Research Tools, Research Reagent

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools

Modification of a Scaffold by Hyaluronic Acid Binding Peptide for Hyaluronic Acid Retention and Tissue Engineering Applications

C10108: Method for Improved Hyaluronic Acid Retention In VivoNovelty: This technology presents a novel use of hyaluronic acid- (HA) binding peptide to aid in the retention of HA at its injection site. This technology has applications in many areas of medicine.Value Proposition: HA is an important component of the extracellular matrix and is used in...

Published: 6/27/2024 | Inventor(s): Jennifer Elisseeff, (Hyeseung) Janice Lee (Logan), Shimon Unterman

Keywords(s): Buffer/Media Solution, Culture Media, Discovery/Research Tools, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools

Human Blood Samples that Contain the Human Granulocytic Ehrlichia

C03088: Human Blood Samples that Contain the Human Granulocytic Ehrlichia Technical Details: Blood and serum samples from patients with corroborated HGE or HME. Blood samples contain antigens and nucleic acids of Anaplasma (Ehrlichia) phagocytophila (HGE) or Ehrlichia chaffeensis (HME); serum contains antibodies to A. phagocytophila (HGE) or Ehrlichia...

Published: 6/27/2024 | Inventor(s): J. Dumler

Keywords(s): Antibodies, Antiserum, Basic Research Biomarker, Blood Samples, Buffer/Media Solution, Discovery/Research Tools, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Blood & Tissue Samples, Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools