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Enhanced Fluorescence Signal through the Application of Aromatic Additives onto the Microscopy Sample for Standard Fluorescence, Fluorescence Microscopy, and Combined Fluorescence MALDI Microscopy/imaging

Value Proposition· Enhanced Fluorescence Intensity: Increases signal strength, enabling detection of molecules that are undetectable with traditional fluorescence microscopy and imaging techniques· Improved Efficiency: Requires less dye to achieve strong fluorescence signals and protects the sample from oxidative degradation, reducing reagent...

Published: 9/12/2025 | Inventor(s): Kristine Glunde, Ethan Yang, Caitlin Tressler, Scot Kuo, Hoku Kahele West-Foyle, Xinyi Shen

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Category(s): Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Medical Devices > Imaging

Composition of Media with Defined Fluid Viscosity for Enhancing Intracellular Delivery of Nanoparticles and Viral Vectors, and Methods of Use

Unmet Need· Production of gene therapies, cell therapies, and recombinant proteins are largely dependent on efficient transfection using viral vectors or nanoparticle vehicles to deliver genetic cargo. However, although numerous transfection reagents have been developed, many strategies still suffer from low efficiency in particular cell-lines...

Published: 9/12/2025 | Inventor(s): Hai-Quan Mao, Yining Zhu, Jingyao Ma, Sean Sun, Zhuoxu Ge, Qin Ni

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Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools > Viruses, Technology Classifications > Research Tools > Nucleic Acids

Kinetically controlled methods to prepare concentrated shelf-stable nucleic acid transfection vehicles

Value Proposition:· Technology creates particles optimally size for use as vehicles for cell transfection.· The reagents and processes for particle creation are kinetically controlled and reproducible.· Cationic particles created using these methods can carry larger payloads than current vehicles.· Reagents and nucleic acid-loaded...

Published: 9/12/2025 | Inventor(s): Hai-Quan Mao, Yizong Hu, Jinghan Lin

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Methods for Clearing and Molecular Analysis in Thick Tissue Sections

Unmet Need· Current techniques for in situ transcriptomics (or spatial transcriptomics) are effectively limited to thin tissue sections of approximately 15 microns due to the poor molecular diffusion and opacity of thicker tissues. Consequently, these techniques are unable to resolve spatial variation of transcription in 3D. Thus, there is a need...

Published: 9/12/2025 | Inventor(s): Reza Kalhor, Soichiro Asami

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Category(s): Technology Classifications > Research Tools > Blood & Tissue Samples, Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools > Specimen Handling, Technology Classifications > Research Tools > Assays

Novel Hexosamine Reagents for Improved Quality Recombinant Glycoprotein Production

Unmet Need: Glycosylation has a major impact on recombinant glycoproteins with important implications for increasing therapeutic use of these compounds. Various approaches are being developed to afford scientists and engineers more control over the type, location, and amount of sugar added to the protein. One technique involves adding sugar reagents...

Published: 9/11/2025 | Inventor(s): Ruben Almaraz, Udayanath Aich, Kevin Yarema

Keywords(s): Buffer/Media Solution, Discovery/Research Tools, Research Reagent, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools

A Platform for Creating an Artificial Blood Brain Barrier

C12117 A Platform for Creating an Artificial Blood Brain BarrierInvention novelty: This invention provides a platform for developing a three-dimensional in vitro model of blood brain barrier (BBB).Value Proposition: The BBB is a dynamic interface that is responsible for maintaining homeostasis of the brain. Disruption of the BBB is associated with many...

Published: 9/11/2025 | Inventor(s): Peter Searson, Andrew Wong

Keywords(s): Basic Research Biomarker, Buffer/Media Solution, Culture Media, Discovery/Research Tools, Research Reagent

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools

Engineered Heart Slices

Engineered Heart SliceJHU REF: C12744Invention Novelty: A novel method of producing acellular cardiac tissue scaffolds with stem-cells for tissue regeneration productsValue Proposition: Tissue constructs using cardiac cells and a base matrix have been developed in the past, and several methods of creating these constructs have been described. However...

Published: 9/11/2025 | Inventor(s): Adriana Blazeski, Leslie Tung

Keywords(s): Basic Research Biomarker, Buffer/Media Solution, Culture Media, Discovery/Research Tools, Research Reagent

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools, Clinical and Disease Specializations > Cardiovascular

A High-efficiency Inducible Cell-cell Fusion Culture System

C11722: High-efficiency Inducible Cell Fusion Culture SystemNovelty: This invention embodies a new culture system that induces cell-cell fusion in transfected cells with high efficiency. In addition to the newfound ability to fuse normally non-fusing Drosophila S2R+ cells, this system provides insight into the mechanisms and interactions involved in...

Published: 9/11/2025 | Inventor(s): Khurts Shilagardi, Peng Jin, Elizabeth Chen

Keywords(s): Basic Research Biomarker, Buffer/Media Solution, Culture Media, Discovery/Research Tools, Research Reagent

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools

The New Culture Method of Rat Distal Pulmonary Vein Smooth Muscle Cell

C10362: The New Culture Method of Rat Distal Pulmonary Vein Smooth Muscle CellValue Proposition: Isolation of primary cell populations is complex and requires a significant amount of technical expertise to produce purified and viable cultures. JHU scientists have developed an optimized method to produce a highly purified population of mammalian intrapulmonary...

Published: 9/11/2025 | Inventor(s): Gongyong Peng, Wenju Lu, Jian Wang

Keywords(s): Basic Research Biomarker, Buffer/Media Solution, Culture Media, Discovery/Research Tools, Research Reagent

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools

Modification of a Scaffold by Hyaluronic Acid Binding Peptide for Hyaluronic Acid Retention and Tissue Engineering Applications

C10108: Method for Improved Hyaluronic Acid Retention In VivoNovelty: This technology presents a novel use of hyaluronic acid- (HA) binding peptide to aid in the retention of HA at its injection site. This technology has applications in many areas of medicine.Value Proposition: HA is an important component of the extracellular matrix and is used in...

Published: 9/11/2025 | Inventor(s): Jennifer Elisseeff, (Hyeseung) Janice Lee (Logan), Shimon Unterman

Keywords(s): Buffer/Media Solution, Culture Media, Discovery/Research Tools, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools

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