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PSMA-targeted Nanoparticles for Therapy of Prostate Cancer

PSMA-targeting nanoparticle for prostate cancer therapyJHU Ref #: C10180Value Proposition:· Engineered nanoparticle system with potent urea-based PSMA inhibitor· Drug loaded nanoparticle· Specific and selective tumor cytotoxicity Unmet NeedProstate cancer affects millions of men globally and is a leading cause of cancer death in...

Published: 1/22/2026 | Inventor(s): Martin Pomper, Ronnie Mease, Sachin Chandran, Sangeeta Ray, Samuel Denmeade

Keywords(s): Cancers, Disease Indication, Drug Delivery Vehicle, Nanoparticles, Prostate Cancer, Single, Targeted Therapy, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Prostate Cancer

Gas6-functionalized extracellular vesicles for treatment of inflammatory conditions

Value Proposition· Superior Anti-Inflammatory Potency: This membrane-associated GAS6 demonstrates over 10-fold higher anti-inflammatory activity compared to equivalent amounts of soluble recombinant GAS6 proteins. · Dual Mechanism of Action: Inhibits pro-inflammatory cytokine production and concurrently stimulates anti-inflammatory responses,...

Published: 1/22/2026 | Inventor(s): Kenneth Witwer, Matias Ostrowski, Martina Fabiano, Alan Adamczyk

Keywords(s):

Breathable Nanomedicine: Inhalable Angiotensin Blockers for Treating COVID-19 and Respiratory Infections

Value Proposition· Provides targeted pulmonary delivery with superior lung pharmacokinetics· Offers mutation-resistant therapeutic action, unlike current vaccines· Reduces risk of progression to severe lung disease in newly diagnosed patients· Applicable to a wide range of respiratory infections and ARDS-related conditions· Enhances...

Published: 1/22/2026 | Inventor(s): Jung Soo Suk, Daiqin Chen, Joe DiCostanzo, Axel Lehrer, Oreola Donini

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > Covid-19, Clinical and Disease Specializations > Infectious Diseases > Respiratory Infections, Clinical and Disease Specializations > Respiratory Diseases, Clinical and Disease Specializations > Respiratory Diseases > Acute Respiratory Distress Syndrome, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Targets

Nanoparticles for Topical Drug Delivery and Treatment of Hair Growth Conditions

Nanoparticles for Topical Drug Delivery and Treatment of Hair Growth ConditionsJHU REF: [C11686]Invention novelty: This invention is a nanoparticle for topical drug delivery targeting hair growth conditions. The particle may be an effective drug delivery tool for conditions such as hirsutism (excess hair) or alopecia (hair loss).Value PropositionThis...

Published: 1/22/2026 | Inventor(s): Sewon Kang, Amanda Nelson, Joshua Wolfe, Jennifer Sample, Xiomara Calderon-Colon, Jason Benkoski, Mellisa Theodore, Julia Patrone, Marcia Patchan, Luis Garza

Keywords(s): Drug Delivery Vehicle, Lipid, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Polymeric particles for sustained delivery of multimodal peptide therapeutics

Value Proposition· Stability: polymeric nanoparticle encapsulation increases and sustains peptide residence time, for increased accumulation in tissue vasculature and maximize treatment effects· Safety: use of nanoparticles reduces toxicity by confining peptide delivery to site of administration· Flexible formulation approaches: system's...

Published: 1/22/2026 | Inventor(s): Jordan Green, Aleksander Popel, Joel Sunshine, Ron Shmueli, Stephany Tzeng, Kristen Kozielski

Keywords(s): Biologics, Drug Delivery Vehicle, Nucleic Acid, Peptide, Polymers, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities

Cationic Polymers with Biphasic Biodegradation

Value Proposition· Delivery Efficacy: Demonstrates more effective gene delivery to cancer associated fibroblasts (CAFs) or human primary fibroblasts than industry gold-standards such as Lipofectamine 2000 and polyethylenimine (PEI).· Cargo Compatibility: Enables encapsulation and delivery of a wide range of cargos including, DNA, RNA,...

Published: 1/22/2026 | Inventor(s): Stephany Tzeng, Ron Shmueli, Nupura Bhise, Joel Sunshine, Jordan Green

Keywords(s): Drug Delivery Vehicle, Polymers, Therapeutic Matter, Therapeutics

A method for inhibiting UHRF1 in colorectal cancer

Value PropositionReversal of colorectal cancer-specific DNA hypermethylationmRNA-based strategy for UHRF1 inhibitionA lipid nanoparticle-based delivery platformUnmet Need1 out of 24 people will develop colorectal cancer. Current technologies do not maximize the bodies’ native ability to suppress tumors. Existing therapies lack specificity and cause...

Published: 1/22/2026 | Inventor(s): Stephen Baylin, Srinivasan Yegnasubramanian, Ying Cui, Xiangqian Kong

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

Lipid Nanoparticle Formulations Capable of Migrating to Systemic Organs Following Intramuscular Administration

Value Proposition:Organ-targeted drug or mRNA delivery to focus therapy on specific tissues. Accessible intramuscular administration, offering broadly applicable, out-of-the-box drug delivery system for a range of therapeutics.Achieves organ-specific delivery without antibodies or targeting ligands, simplifying manufacturing and scalability.Unmet NeedTargeting...

Published: 1/22/2026 | Inventor(s): Hai-Quan Mao, Yining Zhu, Christine Wei, Di Yu

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Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Facile Methods to Attenuate PDMS Drug Absorption

Value Proposition· Increased efficacy: This method effectively eliminates PDMS's drug adsorption property while preserving its beneficial characteristics, making this discovery potentially transformative for any drug efficacy and toxicity studies utilizing microfluidic devices.· Widely applicable: This approach has broader implications...

Published: 1/22/2026 | Inventor(s): Devin Mair, Marcus Williams, Jeffrey Chen, Deok-Ho Kim

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Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Methods and formulations for engineered peptide conjugates for sustained intraocular drug delivery

JHU Ref #: C17191Value Proposition· Reducing the number of daily eye drop doses required for therapeutic effect in the posterior chamber· Limited systemic absorption of medication delivered via topical eyedrops Unmet Need· The mainstay of medication delivery to the eye remains topical eye-drops. While intravitreal injections have been...

Published: 1/22/2026 | Inventor(s): Laura Ensign, Tung Heng Hsueh, Renee Chou, Michael Cummings, Justin Hanes

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Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Computers, Electronics & Software > Machine Learning, Clinical and Disease Specializations > Ophthalmology

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