Search Results - clinical+and+disease+specializations+%3e+oncology+%3e+breast+cancer

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Value PropositionFirst-in-Class Targeting of a Novel Oncogenic Ion Channel: Inhibiting KCNK9 represents a new therapeutic modality in cancers where traditional approachesTumor-Specific Overexpression Enables Selectivity: KCNK9 is overexpressed in various tumors (e.g., breast, gastric, lung) but has limited expression in most normal tissuesPro-Apoptotic...

Published: 6/27/2025 | Inventor(s): John Laterra, Amy Fulton

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Oncology > Lung Cancer, Clinical and Disease Specializations > Oncology > Gastric Cancer, Technology Classifications > Therapeutic Modalities > Antibodies

Novel monoclonal antibody inhibitors targeting potassium channel KCNK9

Unmet Need:KCNK9 is one of 15 mammalian subtypes in the highly conserved family of two-pore domain potassium channels (K2P). Under physiological conditions, KCNK9 is primarily expressed in the brain where it serves to maintain cellular membrane potentials. However, overexpression of KCNK9 has been detected in breast, lung, skin, and other cancers, and...

Published: 6/26/2025 | Inventor(s): John Laterra, Han Sun, Min Li, Amy Fulton

Keywords(s): Antibodies, Biologics, Breast Cancer, Cancers, Disease Indication, Lung Cancer, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases, Clinical and Disease Specializations > Women's Health, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Oncology > Lung Cancer

Combined mammography and quantitative ultrasound breast imaging system

Value Proposition· Comprehensive Examination – integrates conventional ultrasound, ultrasound tomography, photoacoustic imaging, and mammography.· Superior Accuracy – multiple imaging modalities deliver comprehensive and precise breast tissue analysis, reducing the risk of overdiagnosis and/or overtreatment. · Improved Early Detection...

Published: 6/27/2025 | Inventor(s): Emad Boctor, Yixuan Wu, Jeeun Kang, Keshuai Xu, Hyunwoo Song, Russell Taylor, Yuxin Chen, Yifan Yin, Joseph Stayman, Mohammad Salehizadeh

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health

Non-contact Ultrasound Tomography Imaging System

Multifunctional 3D ultrasound imaging systemJHU Ref #: C17859Value Proposition:· Generation of high resolution 3D images for detection and diagnosis of diseases.· Overcomes previous required use of media (water) to image.· Media-less imaging ability allows for integration of other imaging techniques (MRI, PET, CT). Unmet Need· The...

Published: 6/27/2025 | Inventor(s): Jeeun Kang, Emad Boctor, Hyunwoo Song, Yixuan Wu

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Oncology > Breast Cancer, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Medical Devices > Imaging

Hydrogel-Nanoparticle System for Localized Therapeutic Cocktail Delivery in Invasive Ductal Carcinoma (IDC)

Unmet Need: Systemic delivery of drugs often leads to faster clearance, off-target effects, and system-wide unintended toxicity. Current therapeutics designed to specifically target invasive ductal carcinoma (IDC) have a narrow therapeutic index, lack predictive biomarkers, and have serious side effects due to off-target toxicity. This lack of efficacy...

Published: 6/27/2025 | Inventor(s): Efrosini Kokkoli, Denis Wirtz, Gabriella Russo, Paul Kuhn

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer

Photoacoustic Tumor Bed Imaging in Breast Conserving Surgery

Method for identifying residual breast cancer cells following tumor removalJHU Ref #: C17840Value Proposition· Enables medical professionals to identify residual tumor cells for removal in real-time· Reduces time and cost by eliminating need for post-operative analysis of excised tissue· Safe and radiation-free alternative to other...

Published: 6/27/2025 | Inventor(s): Emad Boctor, Russell Taylor, Laura Connolly, Gabor Fichtinger, Parvin Mousavi

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer, Technology Classifications, Technology Classifications > Medical Devices > Imaging

Thymosin-based Peptides for Non-invasive Cancer Detection and Targeted Delivery

Unmet Need:Breast cancer is the second most common cancer among women in the US. In 2017, for every 100,000 women, 125 new Female Breast Cancer cases were reported and 20 women died of breast cancer (see CDC, 2020). Currently, mammography is the primary screening approach for breast cancer with limitations such as occult disease as well as breast tissue...

Published: 6/27/2025 | Inventor(s): Babak Behnam Azad

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer, Technology Classifications > Diagnostics > Diagnostic Imaging

Methylation Markers that Provide Molecular Diagnosis by Distinguishing Between Benign from Malignant Breast Cancer and Predict Risk

Unmet NeedBreast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in low and middle income countries (LMICs), and is expected to increase in incidence due to longer life expectancies, decreased burden of infectious diseases, and changes in reproductive risk factors. In LMICs, breast cancer mortality rates are as high...

Published: 6/26/2025 | Inventor(s): Saraswati Sukumar, Mary jo Fackler, Bradley Downs

Keywords(s): Assay, Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Therapeutic Matter, Therapeutics

Novel selective, covalent inhibitors of DNA polymerase beta, and synthetic lethality in BRCA-deficient cancer

Unmet Need / Invention Novelty: Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors are known synthetic lethal partners for breast cancer gene (BRCA) 1- and 2-deficient cancers. However, not all BRCA-deficient cancers are susceptible to PARP1 inhibitors and others develop resistance. Furthermore, DNA polymerase beta is overexpressed in many cancers, decreasing...

Published: 6/27/2025 | Inventor(s): Marc Greenberg, Shelby Yuhas

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer, Technology Classifications > Therapeutic Modalities > Targets

Novel Biomarker for Breast Cancer Detection Outcome and Treatment Sensitization to Nucleolin and CDK Inhibitors

Unmet Need: Despite widespread research efforts, breast cancer remains the second leading cause of cancer deaths in women. There is an urgent need to identify novel biomarkers and treatment strategies against aggressive forms of breast cancer to improve prognosis and therapy. Technical Details: Johns Hopkins researchers have identified a novel biomarker...

Published: 6/27/2025 | Inventor(s): Vanessa Merino, Saraswati Sukumar, Martin Pomper

Keywords(s): Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics (Old), Prognostic Biomarker, Prostate Cancer

Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Therapeutic Modalities > Targets

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