Search Results - gerald+hart

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Antigens for preparation of monoclonal antibodies

Unmet NeedMonoclonal Antibodies (mAB) serve an important role in both research and medical applications to better understand components of biochemical pathways and the development of chronic diseases (Tabrizi et al, 2006[SN1] ). There is a global need for the advancement of antibodies to help target and fully understand the various, complex, molecular,...

Published: 6/20/2024 | Inventor(s): Gerald Hart

Keywords(s): Antigens, Basic Research Biomarker, Cell Signaling, Discovery/Research Tools, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

CTD110.6 monoclonal antibody

C03770: CTD110.6 monoclonal antibody Technical Details: O-linked N-acetylglucosamine (O-GlcNAc) is a newly described but ubiquitous dynamic modification of key regulatory proteins in side virtually all multi-cellular eukaryotic cells. Recently, this sugar modification has been shown to be as abundant as protein phosphorylation, often competing with...

Published: 6/20/2024 | Inventor(s): Frank Comer, Gerald Hart

Keywords(s): Alzheimer's Disease, Antibodies, Biologics, Cancers, CNS and Neurological Disorders, Diabetes, Discovery/Research Tools, Disease Indication, Metabolic Disorders, Monoclonal Antibodies, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Diabetes, Clinical and Disease Specializations > Metabolic Diseases, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities

PET32a O-GlcNAcase-thioredoxin Expression Vector

C10105: PET32a O-GlcNAcase-thioredoxin Expression Vector Technical Details: Expression and Purification of Recombinant and Endgenous 0- GlcNAcase The human O-GlcNAcase cDNA was subcloned into the commercial expression bacterial expression vector PET32a (Novagen, Madison, WI), as was the shorter splice variant (MGEA5 s), to yield fusion proteins...

Published: 6/20/2024 | Inventor(s): Lance Wells, Yuan Gao, Gerald Hart

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools

C05104: Early Detection of Diabetes ("Pre-Diabetes") Based Upon O-GlcNAc

UNMET NEEDType II diabetes is a metabolic disorder characterized by chronic hyperglycemia and disturbances of carbohydrate, fat, and protein metabolism. Much evidence has accumulated to suggest that screening early in the natural history of diabetes, followed by lifestyle changes, can reverse or delay progression of hyperglycemia and the development...

Published: 6/20/2024 | Inventor(s): Zihao Wang, Kyoungsook Park, Christopher Saudek, Gerald Hart

Keywords(s): Biomarker, Clinical Diagnostics, Diabetes, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Metabolic Disorders

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Diabetes, Clinical and Disease Specializations > Metabolic Diseases, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics