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System for Enhancing Stem Cell Growth & Development Using Fluid Viscosity to Support Tissue Regeneration and Engraftment

Value Proposition· Preserve bone-forming potential (osteogenic phenotype) in soft tissue environments· Reduces immune rejection by promoting an immunosuppressive macrophage response· Enables preconditioning of stem cells for enhanced engraftment success· Applicable to a wide range of regenerative medicine and tissue engineering therapies· Introduces...

Published: 1/22/2026 | Inventor(s): Konstantinos Konstantopoulos, Alice Amitrano, Qinling Yuan, Bhawana Agarwal, Luo Gu, Jude Phillip, Yoseph Dance, Yi Zuo

Keywords(s):

Category(s): Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Musculoskeletal, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Transplantation, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Stem Cells

Extracellular Vesicle mediated nucleic acid treatment in vivo

Value Proposition· Effective: animal studies showed increased survival and decreased tumor burden in liver cancer model.· Fewer side effects: no immunological reactions or off-target effects· Multiple targets: targets the cancer-stroma interactionsUnmet Need· Many current and pipeline cancer therapeutics, including therapeutic...

Published: 1/22/2026 | Inventor(s): Ling Li, Stephen Gould, Florin Selaru

Keywords(s): Drug Delivery Vehicle, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Local Sustained-release Nanocrystal Formulations to Treat and Prevent GI Fibrosis

Unmet Need: Gastrointestinal (GI) fibrosis, the accumulation of scar tissue in the intestinal wall as a complication in common GI autoimmune diseases such as ulcerative colitis (UC) and Crohn’s disease (CD), leads to intestinal strictures, abdominal pain, and reduced intestinal motility. Current pharmacological and surgical treatment methods have significant...

Published: 1/22/2026 | Inventor(s): Laura Ensign, Florin Selaru, Min Kyung Joo, Rachel Shapiro, Ling Li

Keywords(s):

Category(s): Clinical and Disease Specializations > Gastroenterology

New use of Sulconazole to Treat and Prevent GI Fibrosis

Published: 1/22/2026 | Inventor(s): Florin Selaru, Laura Ensign, Ling Li, Min Kyung Joo

Keywords(s):

Category(s): Clinical and Disease Specializations > Gastroenterology

Locoregional Chemotherapy for Liver Cancers

Unmet NeedOver 800,000 people are diagnosed with liver cancer annually. As the leading cause of cancer death worldwide, liver cancer accounts for more than 700,000 deaths annually. Recently, Johns Hopkins researchers have developed new chemotherapeutic drugs to treat liver cancer that demonstrate higher efficacy than the current standard of care for...

Published: 1/22/2026 | Inventor(s): Florin Selaru, Ling Li

Keywords(s): Antagonists/Inhibitors, Cancers, Disease Indication, Drug Delivery Mechanism, Liver Cancer, Non-novel, Predicted Novelty, Repurposed, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Repurposed Drugs, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Oncology > Liver Cancer

Liver-directed gene delivery via endoscopic retrograde cholangiopoancreatograpy (ERCP) directed hydrodynamic injection

Unmet NeedGene therapies are regarded as a potential revolution in the health sciences and pharmaceutical fields. The number of gene therapy trials has been steadily increasing in the United States, with around 170 trials taking place in 2015. All of these trials aim to treat the causes of different diseases instead of only relieving symptoms. Many...

Published: 1/22/2026 | Inventor(s): Florin Selaru, Vivek Kumbhari, Ling Li

Keywords(s): Drug Delivery Mechanism, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Mini-cancers Utilization as Decision Tools for Personalized Cancer Drug Regimens

The present invention includes methods for identifying chemotherapy treatments specifically suited for each cancer patient. The methods include obtaining a biopsy from the cancer patient; establishing a cancer culture from the biopsy; mixing the cancer culture with a matrix forming mini cancers. The mini cancers are then used to screen chemotherapy...

Published: 1/22/2026 | Inventor(s): Florin Selaru, Ling Li

Keywords(s): Assay, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Research Instrument, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Companion Diagnostics, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

Measurement of Blood Volume using Velocity-Selective Pulse Trains on MRI

INVENTION NOVELTY A novel velocity-selective inversion pulse sequence that can be used for MR angiography applications. VALUE PROPOSITION There is a growing demand for high–performance imaging that is beneficial in cases where 1.5 Tesla does not work well enough, such as scanning for developmental abnormalities or performing high–resolution MR angiography,...

Published: 1/22/2026 | Inventor(s): Qin Qin

Keywords(s): CNS and Neurological Disorders, Disease Indication, Distortion Elimination Software, Image Processing Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Integrated Imaging System, Interventional and Surgical Systems, Magnetic Resonance Imaging (MRI), Stroke, Surgical Navigation

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Stroke, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Neurology, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis

Velocity Selective Pulses with Arbitrary Shape

C12796 NOVEL PULSE SEQUENCE FOR NON-CONTRAST ENHANCED MRIInvention novelty: A novel velocity-selective inversion pulse sequence that can be used for MR angiography applications.Value Proposition:There is a growing demand for high–performance imaging that is beneficial in cases where 1.5 Tesla does not work well enough, such as scanning for developmental...

Published: 1/22/2026 | Inventor(s): Peter van Zijl, Qin Qin

Keywords(s): Image Processing Software, Image Reconstruction Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Category(s): Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices

Functional magnetic resonance imaging (fMRI) methodology using transverse relaxation preparation and non- echo-planar-imaging (EPI) pulse sequences

C12282: Enhanced Whole Brain fMRINovelty: This invention is a method to mitigate geometric distortion and signal dropout when performing whole brain imaging by blood-oxygenation-level-dependent fMRI.Value Proposition: Current approaches to blood-oxygenation-level-dependent (BOLD) fMRI rely on 2D gradient echo (GRE) echo-planar-imaging (EPI), and are...

Published: 1/22/2026 | Inventor(s): Peter van Zijl, Craig Jones, Qin Qin, Jun Hua

Keywords(s): Cancers, CNS and Neurological Disorders, Diabetes, Disease Indication, Image Processing Software, Image Reconstruction Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Inflammatory Disorders, Magnetic Resonance Imaging (MRI), Metabolic Disorders

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Diabetes, Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Metabolic Diseases, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices

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