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A Workflow for Multiplex Protein Imaging with Co-detection of Low Abundant Molecules and Proteins

Value PropositionMultiplex Capability: Enables iterative TSA applications, a capability previously unattainable in highly multiplexed platforms which are currently capable of only eight markers per section.High Sensitivity: Detects lowly-abundant proteins to map the full complexity of tissues architecture without degrading tissue morphology or antigenicity...

Published: 9/12/2025 | Inventor(s): Pei-Hsun Wu, Fan Wu, Denis Wirtz

Keywords(s):

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Imaging

Enhanced Fluorescence Signal through the Application of Aromatic Additives onto the Microscopy Sample for Standard Fluorescence, Fluorescence Microscopy, and Combined Fluorescence MALDI Microscopy/imaging

Value Proposition· Enhanced Fluorescence Intensity: Increases signal strength, enabling detection of molecules that are undetectable with traditional fluorescence microscopy and imaging techniques· Improved Efficiency: Requires less dye to achieve strong fluorescence signals and protects the sample from oxidative degradation, reducing reagent...

Published: 9/12/2025 | Inventor(s): Kristine Glunde, Ethan Yang, Caitlin Tressler, Scot Kuo, Hoku Kahele West-Foyle, Xinyi Shen

Keywords(s):

Category(s): Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Medical Devices > Imaging

Anti- TFAM Antibody Detection Assay Predicting Lethal Cardiovascular Events, damage accrual and malignancy in Lupus Patients

Value Proposition:· Specific biomarker for the detection of major adverse events, including thrombosis, in systemic lupus patients.· Serum samples are easily accessible for biomarker detection.· High specificity for thrombotic (clotting) event risk, malignancy and death.· Leverages common laboratory tests for detection for smooth...

Published: 9/12/2025 | Inventor(s): Felipe Andrade, Jose de Jesus Eduardo Gomez-Bañuelos

Keywords(s):

Category(s): Clinical and Disease Specializations > Autoimmunity > Systemic Lupus Erythematosus, Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Inflammation > Chronic Inflammatory Diseases, Clinical and Disease Specializations > Research Tools > Assays, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics

Method for Continuous, Sub-second-resolved, Drift-free and Real-time Interrogation of DNA-based Electrochemical Sensors based on Cyclic Voltammetry

Value Proposition:· Improves temporal stability, reducing batch-to-batch as well as day-to-day variability in sensor performance. · Is drift-free and calibration-free, unlike traditional pulse voltammetry. · Provides additional sensor capacitance information that can report on monolayer stability over time.· Allows for continuous...

Published: 9/12/2025 | Inventor(s): Netzahualcoyotl Arroyo, Miguel Aller Pellitero, Jonathan Mahlum, Samuel Curtis

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Category(s): Technology Classifications > Computers, Electronics & Software > Sensors, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Assays

Potential Energy Landscapes Reveal the Information-theoretic Nature of the Epigenome

Unmet NeedEpigenetics is the study of biochemical modifications carrying information independent of DNA sequence, which are heritable through cell division. To date, methylation landscapes have not yet been rigorously computed.Technology OverviewUsing principles from statistical physics and information theory, JHU inventors have derived epigenetic energy...

Published: 9/11/2025 | Inventor(s): Andrew Feinberg, John Goutsias, William Jenkinson, Elisabet Pujadas

Keywords(s): Assay, Clinical Diagnostics, In Vitro Diagnostics

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

Light-controllable Helicases

Value Proposition· Enhanced accuracy: These enzymes may be used to more accurately sequence DNA · Study control: light activated enzymes may be used for precise manipulation of helicases to be used for in-cell studies.Unmet Need· The enzymatic activity for DNA transcription and translation is frequently used in research and commercial...

Published: 9/12/2025 | Inventor(s): Taekjip Ha, Dmitriy Bobrovnikov, Yann Chemla, Monika Makurath

Keywords(s):

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Assays

Methods for in situ Detection of DNA Sequence Variation

Value Proposition· High-throughput· Assess genetic variants with simultaneous spatial analysis· Interrogate over 100 variants in a single assayUnmet Need· Next generation sequencing has led to an ever-proliferating dearth of genetic information. More recent progress in nucleoside tissue analysis has birthed the field of spatial...

Published: 9/12/2025 | Inventor(s): Reza Kalhor, Soichiro Asami

Keywords(s):

Category(s): Technology Classifications, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Bioinformatics, Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Nucleic Acids

Compositions and Methods for Treating Diseases and Conditions Associated with Activation of the NLRP3 Inflammasome

Unmet NeedAutoinflammatory responses, your body’s innate defense mechanism against infections and stressors, can become overactive and cause chronic inflammation in various tissues and organs. Inflammatory diseases affect more than 200 million people worldwide and include pulmonary hypertension, scleroderma, rheumatoid arthritis, pulmonary fibrosis,...

Published: 9/12/2025 | Inventor(s): Roger Johns

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System for Simultaneous Contractile Force and Calcium Transient Measurement of Engineered Tissue

#C17470Inventor(s): Deok-Ho Kim, Amir Monemianesfahani, Patarajarin AkarapipadUnmet NeedThe global incidence of muscular disorders is significant, and in turn, challenging to quantify. Muscular disorders may be the result of direct abnormalities of the muscles or disorders that are secondary to another condition. Furthermore, these disorders may be...

Published: 9/12/2025 | Inventor(s): Deok-Ho Kim, Amir Monemianesfahani, Patarajarin Akarapipad, Byunggik Kim

Keywords(s):

Category(s): Clinical and Disease Specializations > Genetic Diseases > Duchenne Muscular Dystrophy, Technology Classifications > Computers, Electronics & Software > Sensors, Technology Classifications > Research Tools > Assays, Clinical and Disease Specializations > Cardiovascular > Heart Failure

Targeted capture of custom nucleotide sequences for single-cell sequencing

Value Proposition· Implementation only requires simple modification of current capture beads.· Allows for targeting of custom sequences of interest that may be cell-type specific or expressed at low levels.· Targets RNA molecules without polyA tails.· Inexpensive modification to existing commercial methods. Technology DescriptionResearchers...

Published: 9/12/2025 | Inventor(s): Jonathan Ling, Katherine Irwin, Irika Sinha, Philip Wong, Linda Orzolek, Tyler Creamer

Keywords(s):

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools > Assays

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