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MS-cleavable Photo-crosslinkers for Proteome-wide Photo-crosslinking Mass Spectrometry

Reagents for Crosslinking Mass SpectrometryJHU Ref #: C17605 Value Proposition:• MS-cleavable crosslinkers for capturing protein-protein interactions. • Compounds feature an NHS group and diazirine for covalent non-specific residue linkages.• Avoid the N2 problem. • Compounds are water-soluble and cell-permeable. Technology DescriptionResearchers at...

Published: 1/22/2026 | Inventor(s): Piyoosh Sharma, Stephen Fried, Anneliese Faustino

Keywords(s):

Category(s): Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools > Peptides

INCERTS Methodology for Multiplexing Single Cell Analyses via cDNA Barcoding

A method for integrating cellular phenotype with T cell receptor analysisJHU Ref #: C17820 Value Proposition:· Paired TCR sequencing and phenotypic analysis· High throughput and resolution· Enables pooling of samples Unmet NeedCharacterization of the adaptive immune response has been advanced by single cell RNA-sequencing (scRNA-seq)...

Published: 1/22/2026 | Inventor(s): Harry Larman, Janelle Montagne, Sahana Jayaraman

Keywords(s):

Category(s): Technology Classifications > Research Tools > Bioinformatics, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

Multi-MHC Targeting Bispecific Antibody Platform for T-Cell Activation Against HIV-Infected Cells

Value Proposition· Superior target stability: Targets conserved HIV structural protein-derived peptide:MHC complexes that are highly expressed and stable, unlike rapidly-internalizing variable Env proteins used by current bispecifics· Comprehensive MHC coverage: First platform addressing HIV peptides across MHC-I, MHC-II, and HLA-E pathways,...

Published: 1/22/2026 | Inventor(s): Srona Sengupta, Robert Siliciano, Scheherazade Sadegh-Nasseri, Jacqueline Douglass

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > HIV, Technology Classifications, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools

High-Throughput Machine Vision and Deep-Learning Analysis Method for Cell Migration Tracking

Value Proposition· High Throughput Research Assay: perform experiments on the order of hours, compared to the order of months with existing methods.· Adaptable Algorithm: method evolves as cell motility understanding expands, preventing obsolescence through new discoveries. · Accessible and Integrable: label-free tracking using...

Published: 1/22/2026 | Inventor(s): Pei-hsun Wu, Denis Wirtz

Keywords(s):

Category(s): Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Assays, Technology Classifications > Computers, Electronics & Software > Machine Learning

Quantum Plexcitonic Biosensing

Affinity biosensor for point-of-care diagnosticsJHU Ref #: C17711Value Proposition:· Highly sensitive biosensor that uses quantum plexcitons to detect a variety of biological analytes at extremely low concentrations· Greater specificity than industry leading surface plasmon resonance and quartz crystal microbalance technologies· Can...

Published: 1/22/2026 | Inventor(s): Ishan Barman, Peng Zheng

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Sensors, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers

A Workflow for Multiplex Protein Imaging with Co-detection of Low Abundant Molecules and Proteins

Value PropositionMultiplex Capability: Enables iterative TSA applications, a capability previously unattainable in highly multiplexed platforms which are currently capable of only eight markers per section.High Sensitivity: Detects lowly-abundant proteins to map the full complexity of tissues architecture without degrading tissue morphology or antigenicity...

Published: 1/22/2026 | Inventor(s): Pei-hsun Wu, Fan Wu, Denis Wirtz

Keywords(s):

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Imaging

Enhanced Fluorescence Signal through the Application of Aromatic Additives onto the Microscopy Sample for Standard Fluorescence, Fluorescence Microscopy, and Combined Fluorescence MALDI Microscopy/imaging

Value Proposition· Enhanced Fluorescence Intensity: Increases signal strength, enabling detection of molecules that are undetectable with traditional fluorescence microscopy and imaging techniques· Improved Efficiency: Requires less dye to achieve strong fluorescence signals and protects the sample from oxidative degradation, reducing reagent...

Published: 1/22/2026 | Inventor(s): Kristine Glunde, Ethan Yang, Caitlin Tressler, Scot Kuo, Hoku Kahele West-Foyle, Xinyi Shen

Keywords(s):

Category(s): Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Medical Devices > Imaging

Anti- TFAM Antibody Detection Assay Predicting Lethal Cardiovascular Events, damage accrual and malignancy in Lupus Patients

Value Proposition:· Specific biomarker for the detection of major adverse events, including thrombosis, in systemic lupus patients.· Serum samples are easily accessible for biomarker detection.· High specificity for thrombotic (clotting) event risk, malignancy and death.· Leverages common laboratory tests for detection for smooth...

Published: 1/22/2026 | Inventor(s): Felipe Andrade, Jose de Jesus Eduardo Gomez-Bañuelos

Keywords(s):

Category(s): Clinical and Disease Specializations > Autoimmunity > Systemic Lupus Erythematosus, Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Inflammation > Chronic Inflammatory Diseases, Clinical and Disease Specializations > Research Tools > Assays, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics

Method for Continuous, Sub-second-resolved, Drift-free and Real-time Interrogation of DNA-based Electrochemical Sensors based on Cyclic Voltammetry

Value Proposition:· Improves temporal stability, reducing batch-to-batch as well as day-to-day variability in sensor performance. · Is drift-free and calibration-free, unlike traditional pulse voltammetry. · Provides additional sensor capacitance information that can report on monolayer stability over time.· Allows for continuous...

Published: 1/22/2026 | Inventor(s): Netzahualcoyotl (Netz) Arroyo-Curras, Miguel Aller Pellitero, Jonathan Mahlum, Samuel Curtis

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Sensors, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Assays

Potential Energy Landscapes Reveal the Information-theoretic Nature of the Epigenome

Unmet NeedEpigenetics is the study of biochemical modifications carrying information independent of DNA sequence, which are heritable through cell division. To date, methylation landscapes have not yet been rigorously computed.Technology OverviewUsing principles from statistical physics and information theory, JHU inventors have derived epigenetic energy...

Published: 1/22/2026 | Inventor(s): Andrew Feinberg, John Goutsias, William Jenkinson, Elisabet Pujadas

Keywords(s): Assay, Clinical Diagnostics, In Vitro Diagnostics

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

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