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Methods for High-throughput Identification of Genomic Harbors for Transgene Expression in Cells

Value Proposition:· High-throughput screening of loci for exogenous gene insertion · Quantifies expression level of exogenous genes in cell type of interest Unmet Need· Exogenous or synthetic genes that are inserted into the genome serve various purposes, depending on the context and goals of the genetic modification. This includes...

Published: 3/13/2026 | Inventor(s): Reza Kalhor, Jinwoo Jun, Kathleen Leeper

Keywords(s):

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools > Bioinformatics, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Gene Therapies

Multi-temperature Fluorometric Measurement for Multiplex Analyte Detection with Digital PCR Systems

Multiplex digital PCR diagnostic systemJHU Ref #: C18050Value Proposition:· The use of color-specific and temperature-specific probes allows for unique molecular signals during digital PCR reaction· Can detect low abundance disease biomarkers in a variety of disease settings· Enhanced throughput and sensitivity compared to current...

Published: 3/13/2026 | Inventor(s): Tza-Huei Wang, Fan-En Chen, Yang Zhao, Weiwen Cui, Jiumei Hu

Keywords(s):

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Diagnostics > In Vitro Diagnostics

Method to Use a DNA Oligonucleotide to Bind and Unbind Functional DNA Origami Structures for Applications in Biological Sensing, Transport and Self-assembly

Unmet NeedMolecular assemblies inside cells often undergo structural reconfiguration in response to stimuli to alter their function. Adaptive reconfiguration of cytoskeletal networks, for example, enables cellular shape change, movement, and cargo transport and plays a key role in driving complex processes such as division and differentiation. The cellular...

Published: 3/13/2026 | Inventor(s): Rebecca Schulman, Samuel Schaffter, Joanna Schneider, Yi Li, Daniel Siegal

Keywords(s):

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Assays, Technology Classifications > Therapeutic Modalities > Targets

Spatial Analysis of RNA Using Probe Ligation and Amplification in situ

Unmet NeedTraditional gene expression methods that use bulk RNA analysis lack the ability to resolve transcript location, and thus fail to capture the inherent cellular heterogeneity present in virtually every tissue. Abundance and localization of RNA transcripts mapped to specific regions of tissue can complement histological analysis, providing an...

Published: 3/13/2026 | Inventor(s): Harry Larman, Joel Credle

Keywords(s):

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

MS-cleavable Photo-crosslinkers for Proteome-wide Photo-crosslinking Mass Spectrometry

Reagents for Crosslinking Mass SpectrometryJHU Ref #: C17605 Value Proposition:• MS-cleavable crosslinkers for capturing protein-protein interactions. • Compounds feature an NHS group and diazirine for covalent non-specific residue linkages.• Avoid the N2 problem. • Compounds are water-soluble and cell-permeable. Technology DescriptionResearchers at...

Published: 3/13/2026 | Inventor(s): Piyoosh Sharma, Stephen Fried, Anneliese Faustino

Keywords(s):

Category(s): Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools > Peptides

INCERTS Methodology for Multiplexing Single Cell Analyses via cDNA Barcoding

A method for integrating cellular phenotype with T cell receptor analysisJHU Ref #: C17820 Value Proposition:· Paired TCR sequencing and phenotypic analysis· High throughput and resolution· Enables pooling of samples Unmet NeedCharacterization of the adaptive immune response has been advanced by single cell RNA-sequencing (scRNA-seq)...

Published: 3/13/2026 | Inventor(s): Harry Larman, Janelle Montagne, Sahana Jayaraman

Keywords(s):

Category(s): Technology Classifications > Research Tools > Bioinformatics, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

Multi-MHC Targeting Bispecific Antibody Platform for T-Cell Activation Against HIV-Infected Cells

Value Proposition· Superior target stability: Targets conserved HIV structural protein-derived peptide:MHC complexes that are highly expressed and stable, unlike rapidly-internalizing variable Env proteins used by current bispecifics· Comprehensive MHC coverage: First platform addressing HIV peptides across MHC-I, MHC-II, and HLA-E pathways,...

Published: 3/13/2026 | Inventor(s): Srona Sengupta, Robert Siliciano, Scheherazade Sadegh-Nasseri, Jacqueline Douglass

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > HIV, Technology Classifications, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools

High-Throughput Machine Vision and Deep-Learning Analysis Method for Cell Migration Tracking

Value Proposition· High Throughput Research Assay: perform experiments on the order of hours, compared to the order of months with existing methods.· Adaptable Algorithm: method evolves as cell motility understanding expands, preventing obsolescence through new discoveries. · Accessible and Integrable: label-free tracking using...

Published: 3/13/2026 | Inventor(s): Pei-hsun Wu, Denis Wirtz

Keywords(s):

Category(s): Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Assays, Technology Classifications > Computers, Electronics & Software > Machine Learning

Quantum Plexcitonic Biosensing

Affinity biosensor for point-of-care diagnosticsJHU Ref #: C17711Value Proposition:· Highly sensitive biosensor that uses quantum plexcitons to detect a variety of biological analytes at extremely low concentrations· Greater specificity than industry leading surface plasmon resonance and quartz crystal microbalance technologies· Can...

Published: 3/13/2026 | Inventor(s): Ishan Barman, Peng Zheng

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Sensors, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers

A Workflow for Multiplex Protein Imaging with Co-detection of Low Abundant Molecules and Proteins

Value PropositionMultiplex Capability: Enables iterative TSA applications, a capability previously unattainable in highly multiplexed platforms which are currently capable of only eight markers per section.High Sensitivity: Detects lowly-abundant proteins to map the full complexity of tissues architecture without degrading tissue morphology or antigenicity...

Published: 3/13/2026 | Inventor(s): Pei-hsun Wu, Fan Wu, Denis Wirtz

Keywords(s):

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Imaging

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