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Multi-Compartment Fallopian Tube Organoid Model
Unmet Need: Existing organoid models of the fallopian tube are architecturally simplified compared to the intricate epithelial-lumen interface in scale and structure, and there remains a need in the art for multi-compartment fallopian tube organoids that architecturally simulate the intricate architecture of the epithelial-lumen interface in structural...
Published: 3/14/2025
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Inventor(s):
Meng Horng Lee
,
Gabriella Russo
,
Denis Wirtz
,
Ashleigh Crawford
,
Wenxuan Du
Keywords(s):
Category(s):
Technology Classifications
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Technology Classifications > Medical Devices
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Technology Classifications > Research Tools > Cell Lines
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Technology Classifications > Research Tools > Human Cell Lines
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Technology Classifications > Research Tools > Research Stem Cells
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Technology Classifications > Research Tools > Microfluidics
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Clinical and Disease Specializations > Oncology
Clinical-Grade Therapeutic Progenitors Generated from Universal Donor Tankyrase/PARP-Inhibited Pluripotent Stem Cell Banks
Unmet Need / Invention Novelty: Regenerative cell therapies with conventional, lineage-primed human induced pluripotent stem cells (hiPSC) are limited by variable differentiation efficiency and poor in vivo functionality. There is an unmet need to establish novel methods for efficiently generating functional and transplantable therapeutic progenitors. Technical...
Published: 3/14/2025
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Inventor(s):
Elias Zambidis
,
Ludovic Zimmerlin
Keywords(s):
Category(s):
Technology Classifications > Research Tools > Cell Lines
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Technology Classifications > Research Tools > Stem Cells
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Technology Classifications > Research Tools > Research Stem Cells
3D Shell MEAs for Electrically Active Organoids
Value Proposition· 3D shell MEAs is a novel platform for encapsulation, electrical stimulation, and recording of organoids· Electrophysiological measurements of electrically active 3D organoids. · Relevant to brain development, neurological disorders, drug screening; neuromorphic computing and brain-machine interfaces; and organoid...
Published: 3/14/2025
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Inventor(s):
David Gracias
,
Lena Smirnova
,
Qi Huang
Keywords(s):
Category(s):
Clinical and Disease Specializations > Autoimmunity
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Clinical and Disease Specializations > Neurology
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Clinical and Disease Specializations > Neurology > Motor Neuron Diseases
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Clinical and Disease Specializations > Neurology > Multiple Sclerosis
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Clinical and Disease Specializations > Neurology > Neurodegeneration
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Clinical and Disease Specializations > Neurology > Neuropathy
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Technology Classifications
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Technology Classifications > Research Tools > Stem Cells
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Technology Classifications > Research Tools > Assays
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Technology Classifications > Research Tools > Human Cell Lines
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Technology Classifications > Research Tools > Cell Lines
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Technology Classifications > Research Tools > Research Stem Cells
Human IPSC-Based Drug Testing Platform for Duchenne Muscular Dystrophy
Unmet NeedThe development of new drugs is a capital and time intensive process. For this reason, the development of orphan drugs for those diseases that affect a small subset of the population. One of such diseases, Duchenne’s muscular dystrophy (DMD) affects 1 in 5000 boys worldwide and has no known cure. Current drug screen platforms include animal...
Published: 3/14/2025
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Inventor(s):
Gabsang Lee
,
Kathryn Wagner
,
Congshan (Sunny) Sun
Keywords(s):
Discovery/Research Tools
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Disease Indication
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In Vitro Research Tool
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Muscular Disorders
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Small Molecules
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Therapeutic Matter
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Therapeutic Substance
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Therapeutics
Category(s):
Clinical and Disease Specializations > Rare Diseases
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Technology Classifications > Therapeutic Modalities > Small Molecules
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Technology Classifications > Research Tools > Research Stem Cells
Generation of PBMC-Originated, iPSC-Derived Corneal Endothelial Cells
Unmet NeedFuchs’ dystrophy, a progressive, hereditary disease of the cornea, is the leading cause of corneal transplants both in the US and worldwide. The disease results in the dysregulation and destruction of corneal endothelial cells which are responsible for keeping the eye properly hydrated. As the disease progresses, patients will experience blurred...
Published: 3/14/2025
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Inventor(s):
Sheikh Amer Riazuddin
,
John Gottsch
,
Shahid Khan
,
Muhammad Ali
Keywords(s):
Biologics
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Cell Therapy
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Corneal Dystrophy
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Disease Indication
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Eye Disorders
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Single
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Therapeutic Matter
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Therapeutic Substance
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Therapeutics
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Therapy Type
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Whole cell
Category(s):
Clinical and Disease Specializations > Ophthalmology > Corneal Dystrophy
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Technology Classifications > Therapeutic Modalities > Cell Therapies
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Technology Classifications > Research Tools > Research Stem Cells
Partitioning of Human Mesenchymal Stem Cells based on CD107a Expression
JHU Ref #: C15392Value PropositionImproved Stem Cell Isolation: Enables efficient and scalable separation of stem cells predisposed to fat or bone tissue regeneration.Clinically Feasible: Uses magnetic-activated cell sorting (MACS), a cost-effective and translational alternative to fluorescence-activated cell sorting (FACS).Enhanced Therapy Potential: Optimized...
Published: 3/14/2025
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Inventor(s):
Aaron James
Keywords(s):
Cell Lines
,
Discovery/Research Tools
,
Human Cell Lines
,
In Vitro Research Tool
Category(s):
Technology Classifications > Research Tools > Human Cell Lines
,
Technology Classifications > Research Tools > Research Stem Cells
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